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        Cluster Headache Help and Support >> Cluster Headache Specific >> CH, REM sleep, Circadian clock, Nicotine
        
(Message started by: Annette on May 11^th, 2008, 8:20am)

Title: CH, REM sleep, Circadian clock, Nicotine
Post by Annette on May 11^th, 2008, 8:20am

As a follow up to the other thread, here is some more information that I have found to be interesting and relevant. However, to avoid turning the information into something personal, I will not add my own interpretation but will post the info in its pure form and let the readers connect the dots and draw their own conclusion.

1- Hypocretin receptors gene strongly associated with CH : this was established in the other thread.

2- Nicotine binds to the same receptors in the brain : this was also established in the other thread.

3- Hypocretin 1 and 2 are neuropeptides that act on the hypothalamus to regulate the sleep wake cycle ie having a control effect on the circadian clock. They also affect REM sleep.

http://www.ingentaconnect.com/content/bsc/ejb/2005/00000272/00000022/art00002

http://www.journals.elsevierhealth.com/periodicals/sleep/article/PIIS1389945702000680/abstract

4- The centre for controlling REM and the sleep wake cycle/circadian clock is in the suprachiasm of the hypothalamus

http://www.websciences.org/cftemplate/NAPS/archives/indiv.cfm?ID=20033652

5- The effect of hypocretin on the suprachiasmatic nucleus

http://cat.inist.fr/?aModele=afficheN&cpsidt=16302776

6- Prof Goadsby found abnormal area of cell growth in the suprachiasmatic nucleus: This has been established before.

7- Hypocretin exerts effect on the suprachiasmatic nucleus via the fasciculus retroflexus, which in turns affect REM sleep and the circadian cycle

http://www.ncbi.nlm.nih.gov/pubmed/9820735

http://www.jneurosci.org/cgi/content/full/18/23/9996/F10

http://lib.bioinfo.pl/meid:168569

8- Effect of nicotine on the fasciculus retroflexus

http://edition.cnn.com/2000/HEALTH/11/09/nicotine.brain/index.html

http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=476145

9- Nicotine effect on REM sleep

http://www.springerlink.com/content/y63gqr12hpeft47u/

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0P-4K716BW-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=1ea92538a22f0471db08f6bb60255a9c

10 - CH attacks occur most commonly during REM sleep : this fact is well known.

There you go, connect the 10 dots and you can find your own conclusion.

Have fun and thanks again for reading :)

Edited to add: More information was found in textbooks and in articles that are copy righted and cant be posted here, but you get similar information from those I included above.

Title: Re: CH, REM sleep, Circadian clock, Nicotine
Post by Redd on May 11^th, 2008, 9:28am

A quick correction.

Quote:

6- Prof Goadsby found abnormal area of cell growth in the suprachiasmatic nucleus: This has been established before.

http://bmb.oxfordjournals.org/cgi/content/full/65/1/223

Quote:

Using the voxel-based morphometric analysis of the structural T1-weighted MRI scans, a significant structural difference in grey matter density was found in patients with cluster headache when compared to healthy volunteers. This difference consists of an increase in volume and was present for the entire cohort. The difference was also present when patients in and outside a bout were compared with the control group. This structural difference is bilaterally situated in the diencephalon, adjacent to the third ventricle and rostral to the aqueduct, co-inciding with the inferior posterior hypothalamus. In terms of the stereotaxic co-ordinates54, it is virtually the identical area in which activation during an acute cluster headache attack is demonstrated in the PET study. No other areas of change were noted53.

I snipped the article Annette, and the findings are in red. It's been established the location of the structural differences, yes, but they are not in the suprachiasmatic nucleus, which is located in the superior anterior region.

Title: Re: CH, REM sleep, Circadian clock, Nicotine
Post by Annette on May 11^th, 2008, 5:08pm

Thats great ! Pegg ! Thanks for that !

But then Goadsby also talked about abnormal cells in the suprachiasmatic nucleus too

" Peter Goadsby: We don't know what causes them in the sense of what the initial problem is. But our understanding of where the problem is has really taken off in the last 12 months, and particularly in the last couple of months. We have found that the area where the abnormality is in the brain, an area called the hypothalamus, which is in the deep part of the brain, it's the same area that's involved in what's called circadian rhythm, in the day/night rhythm. There's an area of the brain called the suprachiasmatic nucleus, a group of cells that is the master pacemaker if you like, it's the thing that apart from the fact that we get paid to get up in the morning, it's the thing which wakes you up and the thing which puts you to sleep. It's the thing which causes our body clock, that cycles over the slightly more than 24 hour period. Now the abnormalities we found in cluster headache are in the same part of the brain, and we think that in understanding this group of cells within the brain, we'll start to understand some very important principles about the way the body cycles; not only cycles from the day/night sense, but cycles in bigger cycles that go over months and years."

His own words from

http://www.abc.net.au/rn/talks/8.30/helthrpt/stories/s42434.htm

Plus

" Specialized Cells Key to Treatment, Prevention

Goadsby’s research has been focused on better understanding a group of specialized cells in the hypothalamus called the suprachiasmatic nucleus. These cells act much like the battery for the body’s clock. Goadsby and his colleagues believe that they are responsible not only for the body’s 24-hour cycles, but for bigger cycles that occur over many months or years.

Goadsby believes these cells are critical to understanding not only what causes such headaches, but also how to treat and prevent them."

This is from

http://psychcentral.com/lib/2006/cluster-headaches-brain-biology-provides-important-clues?pp=2

There is also another recent article that showed hyperactivity of this area during a cluster attack under PET scan, but the article is copy righted and I cant quote it here.

It looks like Goadsby has found abnormality in both regions.

Title: Re: CH, REM sleep, Circadian clock, Nicotine
Post by nani on May 11^th, 2008, 5:44pm

on 05/11/08 at 08:20:14, Annette wrote:

I will not add my own interpretation but will post the info in its pure form and let the readers connect the dots and draw their own conclusion.

So after 6 pages, and over 7,200 of your own words on the other thread ... you've started this thread for our convenience. Will you be replying to each reply in this one, as well?
I'm just trying to prepare myself.

Title: Re: CH, REM sleep, Circadian clock, Nicotine
Post by BMoneeTheMoneeMan on May 11^th, 2008, 6:24pm

on 05/11/08 at 17:44:59, nani wrote:

You forgot to hit your mute button again, Doll.

We all heard that........ :-X

Title: Re: CH, REM sleep, Circadian clock, Nicotine
Post by Annette on May 11^th, 2008, 7:40pm

on 05/11/08 at 17:44:59, nani wrote:

So after 6 pages, and over 7,200 of your own words on the other thread ...

WOW ! You sat there and counted how many words I wrote in that thread ? :o I am impressed !!

I will reply to all comment on this thread via PM then :)

Title: Re: CH, REM sleep, Circadian clock, Nicotine
Post by AussieBrian on May 12^th, 2008, 8:14am

on 05/11/08 at 17:44:59, nani wrote:

So after 6 pages, and over 7,200 of your own words on the other thread ...

NetNani strikes again.

Title: Re: CH, REM sleep, Circadian clock, Nicotine
Post by michael on May 12^th, 2008, 8:24am

Please Annette. Some of us are interested. We want to see your replies.

I know its hard, but please don't be put off by the odd snipe - they are the minority.

Mike

Title: Re: CH, REM sleep, Circadian clock, Nicotine
Post by Paige_H. on May 12^th, 2008, 8:34am

Maybe I'm crazy. Well, this cycle has made me crazy. But it almost sounds like in episodic cases that our "clocks" are resetting themselves or something.

Title: Re: CH, REM sleep, Circadian clock, Nicotine
Post by starlight on May 12^th, 2008, 3:21pm

Annette,

I think this is an interesting idea you have come up with and don't discredit it.

I just have one thought, and I'm sure others will chime in if I'm off base--as far as the reported high levels of smoking in CHers, I think that issue needs to be looked at holistically (from all sides). CH, whether or episodic or chronic, over time, can cause a certain "background anxiety", which again, over time, could definitely contribute to someone becoming a smoker, or, in my opinion, increasing how much a person smokes. I am doubtful that there is any underlying phenomenon that makes CHers more prone to addiction than the rest of the population. (This is something I have thought in the past whenever I have heard this mentioned on this board about CHers.) Thanks for your ideas--just thinking "out loud".