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Topic: Baclofen (Read 783 times) |
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EstieSA
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Anybody here using it / used it previously ?
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Bob_Johnson
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Re: Baclofen
« Reply #1 on: Dec 19th, 2007, 9:49pm » |
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Curr Pain Headache Rep. 2001 Feb;5(1):79-82.
The use of baclofen in cluster headache.
Hering-Hanit R, Gadoth N.
Department of Neurology, Meir General Hospital, Sapir Medical Center, 59 Jabotinski Street, Kfar Saba 44288, Israel.
Cluster headache is a rare, clinically well-characterized disabling disorder that occurs in both episodic and chronic forms. The very painful short-lived unilateral headache attacks are associated with autonomic dysfunction. A large number of drugs such as ergotamines, steroids, methysergide, lithium carbonate, verapamil, valproate, capsaicin, leuprolide, clonidine, methylergovine maleate, methylphenidate, and melatonin are considered beneficial for prophylaxis. Nevertheless, this extremely painful condition is occasionally refractory to conventional treatment. The antispastic agent baclofen has been shown to possess an antinociceptive activity. Its efficacy in neuralgias, central pain following spinal lesions, painful strokes, migraine, and medication misuse chronic daily headache suggests that it may be useful for prevention of cluster headache attacks. Therefore, we treated 16 symptomatic patients with cluster headache with daily baclofen, 15 to 30 mg, in three divided doses for the cluster period and 2 weeks after. Within a week, 12 patients reported the cessation of attacks. One was substantially better and became attack free by the end of the following week. In the remaining three patients, the attacks worsened and corticosteroids were prescribed. One of these was also given verapamil. Three of the 16 patients had an additional cluster period, which cleared with a second course of baclofen. In this pilot study, baclofen seemed to be effective, safe, and well tolerated for cluster headache, and seemed to retain its efficacy on repeated clusters.
Publication Types:
Clinical Trial
PMID: 11252142 [PubMed]
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Bob Johnson
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Gator
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Re: Baclofen
« Reply #2 on: Dec 20th, 2007, 9:54am » |
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I tried it a couple years ago. The recommended dose for ch is up to 30mg. When that didn't work, my neuro had me push it up to 80 mg. Still didn't work for me.
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EstieSA
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Re: Baclofen
« Reply #4 on: Dec 21st, 2007, 11:48am » |
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Can it be taken with other meds , ie Cymbalta & Topamax...
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Gator
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Re: Baclofen
« Reply #5 on: Dec 21st, 2007, 12:12pm » |
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Talk to your doctor, pharmacist and do some research on your own. This website has a drug interaction checker:
http://www.drugdigest.org/DD/Home
It didn't show any interaction between the three.
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EstieSA
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Re: Baclofen
« Reply #6 on: Dec 21st, 2007, 2:10pm » |
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on Dec 21st, 2007, 12:12pm, Gator wrote:
Thanks for the info ! I like to have my facts straight when visiting my doctor! 
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| « Last Edit: Dec 21st, 2007, 2:15pm by EstieSA » |
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