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        Cluster Headache Help and Support >> Medications, Treatments, Therapies >> Fresh Research - Sumatriptan and Heart Attack
        
(Message started by: floridian on Dec 29^th, 2005, 12:33pm)

Title: Fresh Research - Sumatriptan and Heart Attack
Post by floridian on Dec 29^th, 2005, 12:33pm

Quote:

Pediatr Cardiol. 2005 Jul-Aug;26(4):464-6.

A case of myocardial infarction with sumatriptan use.

Erbilen E, Ozhan H, Akdemir R, Yazici M.

Department of Cardiology, Faculty of Medicine, Abant Izzet Baysal University Duzce, Kardiyoloji Klinigi, Konuralp, Turkey.

Sumatriptan is widely used in the treatment of acute attacks of cluster headache. It is a serotonin-1 (5HT-1) agonist. Several studies have reported an association between sumatriptan use and myocardial infarction, possibly due to the generalized vasoconstrictive nature of this agent. We report a 16-year-old male patient presenting with acute inferior myocardial infarction after sumatriptan use without any known risk factors of coronary artery disease.

PMID: 16374699 [PubMed - in process]

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by Gator on Dec 29^th, 2005, 12:41pm

Thanks, bro. Don't all/most of the triptan meds carry the same risk?

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by floridian on Dec 29^th, 2005, 12:53pm

on 12/29/05 at 12:41:31, Gator wrote:

Thanks, bro. Don't all/most of the triptan meds carry the same risk?

They are all vasoconstrictors and have some risk - the standard answer is that in 90% of people (those without certain heart conditions) they are acceptably low risk. But a 16 year old kid with no known risk factors??

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by nani on Dec 29^th, 2005, 1:10pm

on 12/29/05 at 12:53:16, floridian wrote:

But a 16 year old kid with no known risk factors??

That is scary as hell!
Those of you who use a lot of triptans... especially the smokers...
please reconsider. :-/

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by Bob_Johnson on Dec 29^th, 2005, 7:22pm

I saw this report when I checked PubMed today and decided to not post it. It's not wise to jump to conclusions about any med based on one case and, especially here, we have no other information about underlying issues which have not been reported.

We have multiple reports covering thousands of people using this class of meds showing high levels of safety and effectivenesss.

Life is a constant balancing of cost/benefit and it's important to not lose sight of this reality. Whether we are taking an aspirin, driving a car, or taking an anesthetic for a dental procedure--there is risk.

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by kcopelin on Jan 1^st, 2006, 9:44am

Bob, spoken like a true philosophic clinician. My mother-in-law, bless her little pea-pickin' brain, reads every single warning on every single thing that she ingests. She always has side-effects. And they are always listed somewhere on the pt info pamphlet. She is a truly amazing subject for study. On the other hand, those who take tripans daily, and have other risk factors, really should keep this in mind. Some of the clusterbuster methods don't have the risk involved, and might be worth checking into. For the record though, Imitrex has saved the lives/sanity of many.
It is all about weighing the risks vs. benefits.
kathy

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by Jasmyn on Jan 1^st, 2006, 11:11am

on 01/01/06 at 09:44:44, kcopelin wrote:

On the other hand, those who take tripans daily, and have other risk factors, really should keep this in mind. Some of the clusterbuster methods don't have the risk involved, and might be worth checking into.
kathy

Please try to convince our Viking Hero Svenn to at least consider some clusterbuster methods as he fall in the high risk category and uses triptans daily and in high dosages.

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by clustersurgeon on Jan 1^st, 2006, 1:33pm

I was the First in the worlds who talk about that;
You can see cluster migraine surgery on Challenger Sat TV on Hotbird,
From Padova, ITALY
www.migrainesurgery.8m.net
Happy New Year.
Where you can reads about trpitans Danger.

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by LeLimey on Jan 1^st, 2006, 1:44pm

]For the attention of anyone new reading this.
ClusterSurgeon is a troll.
He has registered on this site under many names and deleted all of them after being run off for dangerous, ridiculous and worthless views.
He is not a doctor.
He has no medical training and his so called medical certification comes from schools with no medical education programmes.
Do not be deceived.
His opinion and views are worth their weight in manure so unless you have roses read no further!
Oh and he does not have cluster headaches so if you are looking for help his views are of no value to you.

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by Svenn on Jan 2^nd, 2006, 5:50am

on 01/01/06 at 11:11:25, Jasmyn wrote:

Please try to convince our Viking Hero Svenn to at least consider some clusterbuster methods as he fall in the high risk category and uses triptans daily and in high dosages.

The neuroes and cardioes here saying that triptans"imitrex" is NOT that bad for the heart as first expected.

Have asked a lot of docs about my situation and in summary they say that i can do up to 5 shots a day without any problem.

I believe we need to read the warnings on the manuals inside the cases with new eyes since most of the warnings is from when trex first come to us early 90s

Svenn

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by Jasmyn on Jan 2^nd, 2006, 10:45am

on 01/02/06 at 05:50:23, Svenn wrote:

That still does not stop me from worrying about you, you stubborn Viking! ;)
I agree, as CHers we do tend to be on higher dosages of meds and survive but the Clusterbusters have delivered great results with less harm over the past few years.

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by Bob_Johnson on Jan 2^nd, 2006, 2:36pm

Headache. 2004 Feb;44(2):178-82.

Frequent triptan use: observations on safety issues.

Robbins L.

Department of Neurology, Rush Medical College, Chicago, Ill. 60062, USA.

OBJECTIVE: To examine the safety of frequent triptan use over extended periods. For a small group of patients with refractory migraine plus chronic daily headache, triptans are effective. METHODS: This retrospective study primarily evaluated the cardiac safety of daily triptan use in 118 patients and, in addition, hematologic tests were assessed. Each patient had utilized a triptan for a minimum of 4 days per week for at least 6 months. Patients with rebound headache had been withdrawn from the triptans. Most patients (97 of 118) averaged 1 tablet daily; most would occasionally go for several days without a triptan. Forty patients had taken a triptan for 6 months to 2 years, 37 patients from 2 to 4 years, and 41 for 4 or more years. RESULTS: Routine hematologic tests were performed periodically on all patients, and no abnormalities were attributable to triptans. Almost all patients had an electrocardiogram, and no abnormal electrocardiograms were felt to be related to triptans. Cardiac echocardiography was performed in 57 patients. The 10 abnormal echocardiograms were not due to triptans. All 20 cardiac stress tests revealed normal findings. Adverse events were minimal; 9 patients described fatigue due to triptans, and 5 had mild chest tightness. CONCLUSION: This long-term study of 118 patients indicates that frequent triptan use may be relatively safe.

PMID: 14756859 [PubMed - indexed for MEDLINE]

Title: Re: Fresh Research - Sumatriptan and Heart Attack
Post by Beastfodder on Jan 5^th, 2006, 9:51am

Thanks for this - O2 and clusterbusters makes complete sense for me 'coz they work better than the triptans I've been prescibed.

The fact that they're much less likely to lead to heart disease is a side effect I will be able to live with.

Anyone for Lithium or Pizotifen/Sanomigran?

The latter's side effects include - Dry mouth, fast heartbeat, difficulty urinating (passing water), constipation, drowsiness, increased appetite and weight gain, feeling sick, dizziness, skin rashes, swelling of the limbs, muscle pains, pins and needles, sexual problems, seeing or hearing things that are not real, or very rarely depression.