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        New Message Board Archives >> Medications, Treatments, Therapies 2005 >> Seeking your thought- Triptans
        
(Message started by: pubgirl on Sep 1st, 2005, 4:16am)
Title: Seeking your thought- Triptans
Post by pubgirl on Sep 1st, 2005, 4:16am
Sorry longish post, but am in thinking mode....... :-[

Carrie and my GP have just made me aware of something I knew instinctively as being an old bird I know my body quite well, and I know it doesn't like Imigran (especially as posted before in high dose nasals)
They tell me variously that Imigran is very old for a triptan, is very short-lived, is the most likely triptan to cause side effects and the least likely to block attacks/most likely to cause rebounds. Most of this information is based on migrainers as they are studied more than us, but sorry to say I don't think WE should ignore it because of that as I believe we are closer cousins than many here think (IMHO only)

I have already been instinctively using Zomig with my 02 prophylactically with some small success (a few hours only) and am picking up a Frova prescription today to try the same thing with that as growing anecdotal evidence suggests that it may work for some people in this way.


I am looking for people's opinions or real evidence, would love either as I am just thinking at the moment.

Why is Imigran the only injectible Triptan?

Why are there only two Triptans with fast delivery systems? is this because we are supposedly few and migrainers many and they don't need it?

Zomig nasal is faster than Imigran nasal and the effects last longer, why isn't this common knowledge?

Is Imigran as big a part of the problem of CH conditions worsening over time as Verapamil (which usually takes the blame for episodics turning chronic)

Thanks in advance if you have the time to answer this.

Wendy the Brit
Title: Re: Seeking your thought- Triptans
Post by don on Sep 1st, 2005, 7:12am

Quote:
Why is Imigran the only injectible Triptan?


That is a damn good question and one I never thought of.

Must have something to do with patent laws or cost/ benefit ratio to manufacture and market injectables.
Title: Re: Seeking your thought- Triptans
Post by oudista on Sep 1st, 2005, 1:02pm
Only other Triptan I ever tried was Rizatriptan (Maxalt melts) which sadly did absolutely nothing for me :'(. Others may have better experiences.

Tony
Title: Re: Seeking your thought- Triptans
Post by NotH20 on Sep 2nd, 2005, 11:00am
Wendy,

DHE is also in the injection form as an abortive, but not sure if it's a Triptan or not.  

Good luck w/ the Frova.....

Mia
Title: Re: Seeking your thought- Triptans
Post by Jill on Sep 2nd, 2005, 1:25pm

Quote:
Why are there only two Triptans with fast delivery systems? is this because we are supposedly few and migrainers many and they don't need it?


I am not sure that these are triptans but there a couple of abortives that can be used that have a fast delivery.. well as fast as they can..Let me see if I can think of them..

Both Maxalt and Zomig come in dissolvable tablets - Maxalt worked pretty fast for me and worked great for awhile.. then it stopped working.

There is also Migranal nasal spray which I think is the same thing as the DHE nasal spray, correct me if I am wrong. I know that there is another one but I cant think of it right now.. my mind isnt working right.

Those are the ones that I can think of. I know my neuro put me on relpax and said to take it when I felt the first twinge, even if it didnt go full blown because it lasts a lot longer than imitrex and has the possibility to prevent them. That didnt happen but that is what he said,...

Hope this helps some.

Jill
Title: Re: Seeking your thought- Triptans
Post by pubgirl on Sep 2nd, 2005, 5:48pm
Sorry folks , think you are missing my point. No offence Jill but I'm not looking for options for currently available triptans that are SLOWER than Imi or Zomig injectibles/nasals (e.g. dissolvables) and eletriptan appears useless as it is slow acting AND the half-life is less than some other triptans. I'm trying to scale down my dosages of Imi as I KNOW this is the way to go for me, so I'm afraid I'm also sure as hell not going to have DHE in any form! Frankly my view is that if Imigran is a dinosaur triptan, DHE is a Big Bang one!. In patient IV DHE may be a different matter, but part of my regime, no thanks.

What I'm looking for I suppose is people's experiences of using triptans in different ways and I suppose truthfully I'm looking for a fast acting form of a triptan whose effects last longer and whose side effects are minimal which I don't think exists anywhere in the world.

Where I am now is that Frova is giving me some potentially great prophylactic help but is no use as an abortive as it is pill form only. Used with 02 it is serving me very well at the moment and I am not touching Imi or prevents, but when I am without 02 I have to reluctantly use Imi or Zomig as NONE of the so-called "new age" triptans with a longer half-life come in a fast delivery form to abort as well.

I don't know the pharmaceutical restrictions but right now I want Frova or other long lasting triptan  in subcutaneous or nasal version to replace Imi or Zomig. Doesn't bloody exist!

Unless you know different????



Wendy
Title: Re: Seeking your thought- Triptans
Post by Jill on Sep 2nd, 2005, 5:54pm
I am sorry, I did misunderstand you... :-[

I havent heard of any triptans that are longer last AND come in the injectable form... sorry..

Have you tried the Relpax? It is a pill, not as potent as imitrex or Zomig, and lasts alot longer. I know that I get bad side effects from imitrex but none with Relpax...

Sorry that I misunderstood you...

Jill
Title: Re: Seeking your thought- Triptans
Post by pubgirl on Sep 2nd, 2005, 6:02pm
Relpax is eletriptan, slower than Imi or Zomig , shorter half-life than Frova, can't see the point of it


Wendy
Title: Re: Seeking your thought- Triptans
Post by hwm54112 on Sep 3rd, 2005, 4:09pm
Glaxo has a patent.

There are other injectables in clinical trial. It's all about the money. The pharmaceutical industry doesn't care how we feel only about how much money they make. More people have acid reflux than cluster headache. Therefore they make more selling little purple pills than injectables. The pharmaceutical industry will never find a cure. If they did, they would put themselves out of business.

Imagrin has a higher advertising budget than Zomig

I believe I read somewhere (same place as the clinical study info) that all subcue triptans , by virtue of being subcue triptans, have about the same half life, and therefore the same longevity. The delivery system has an effect on the half life. For instance, antibiotic treatment can be done for ten days by pill or one day by IV. Anti-depressants-4-6 weeks to kick in by pill, one week by injection but you have to be hospitalized.

My question- Is the drug truly responsible for the condition worsening or is it just time itself that worsens the condition? After all, everything else deteriorates with time alone.

Far-fetched idea? Before high doses of verapamil and sumatriptan, if I used 02 I would have a moderate CH for several hours, as long as I kept using the 02. If I did nothing, I would have a horrendous CH for 45 minutes. This was consistent for numerous headaches (daily for months on end). Could it be that the beast must deliver a certain amount of pain before it subsides?  Expressed mathematically, does 10 units of pain for 1 minute equal 1 unit of pain for ten minutes and then it subsides in either instance? Anything is possible. Therefore. does the reduction of pain (caused by drugs), increase the length of the  episodes, making the episodes appear to become chronic? There are countless analogies in nature, ie: high water flow erodes quickly until the bank is gone (episodic), low pressure erodes slowly until the bank is gone (chronic). In either case, the bank is gone.

More support of this theory- Prior to having surgery, I was episodic, having CH's daily for 2-3 months twice a year. Immediatley after surgery for CH, I had headaches daily for two years but felt no pain (nerves were destroyed in the painful region). The headaches stopped for about two years, then started up again but still without pain being felt for another year. At that point, the nerves grew back, the pain started up again chronically.  I felt no pain for five years and  used no drugs. When the CH's returned with pain, my episodes began to last 2=3 years before remissing for  one year intervals. These patterns have been like clock work for thirty years.

Not being a smart ass, Just thinking also, you seem to have an objection to dinosaur triptans and more objection to big bang DHE because they are old. Has it occurreds to you that they may be safer drugs because we no the longer term side effects of old drugs? Look at the vioxx disaster. When given a choice, I always opt for the older, non-designer drugs. We know better what they're gonna do down the road. When I first deteriorated to injectables, I opted to try DHE first

Sorry my answer is so long. I went off.   :)
Title: Re: Seeking your thought- Triptans
Post by pubgirl on Sep 3rd, 2005, 9:06pm
Long but very interesting!

Quite a lot of people seem to subscribe to the view that we are "preprogrammed" to have the attacks, so all we do is delay them, and sooner or later we will have them. I'm not sure about this as I haven't much personal history to go on (thank God!)

I object to Imigran because for me it gets rid of the attack I use it for, but it makes me feel awful and the effects are so short lasting. I also really do think my attacks afterwards are worse. Just a personal feeling.
I object to ergotamine as I don't like the idea of a drug that so definitely compromises circulation. As a smoker I'm already doing that and it worries me to do it further.

I have used Frova but not for an attack itself as it is too slow and I prefer 02. I am currently using it with 02 and am going 10 hours pain free before the next attack. It also appears to clear all the shadowing during that time.

From what you say though, if Frova (or another longer lasting triptan) were in injectible form, it's half life would be reduced anyway, so that may squash that dream. :(

Wendy
Title: Re: Seeking your thought- Triptans
Post by don on Sep 4th, 2005, 7:11am

Quote:
triptans that are longer last


A longer lasting triptan makes no sense. Aren't all triptans designed to eliminate one hit at a time?
Title: Re: Seeking your thought- Triptans
Post by lionsound on Sep 4th, 2005, 8:30am

on 09/04/05 at 07:11:17, don wrote:
A longer lasting triptan makes no sense. Aren't all triptans designed to eliminate one hit at a time?


sort of. I could be totally wrong here, but I believe that some of the ones with a longer half-life are designed to battle a migraine which can be not as much as quick hit,more like a long drawn out neuro event.
Title: Re: Seeking your thought- Triptans
Post by pubgirl on Sep 4th, 2005, 8:33am
I thought triptans were designed to kill a migraine and keep it away for a "while", I don't see any reason why, if they have the will to do it (which they haven't I don't think because it wouldn't make their development money back for the)  that the drug companies can't design one which kills fast via fast delivery methods AND blocks attacks for a useful amount of time


Wendy
Title: Re: Seeking your thought- Triptans
Post by BikerBob on Sep 4th, 2005, 4:20pm
During the peak of my most recent cycle, I was consistently getting hit hard at about 7pm, 10pm, 1am, 3am and 5am. O2 at 12 lpm would abort the 7pm, 10pm, 3am and 5am hits in 10-15 minutes but the 1am hits were too strong for O2 so I had to resort to Imitrex injections for those. On several nights, I took a 100mg Imitrex tablet at midnight, an hour before the expected 1am hit, as a preventive for the 1am and 3am hits and was able to get 6 hours sleep.

BB
Title: Re: Seeking your thought- Triptans
Post by Gator on Sep 5th, 2005, 2:05pm
It has always been my understanding that the purpose of triptans was to kill a single attack.  Any lasting prophylactic effect would be a secondary benefit.

As was said before it's all about the money.  There are meds that work well enough for the largest percentage of the migrainers.  That's where the money is.  The ongoing improvement and production of triptans is going to be geared towards that market.  There is no med out there specifically for CH, because the return on the investment in R&D would be minimal to non-existant, in relative terms.

Speaking strictly on the trex vs zomig thing.  Each person metabolizes the meds differently and therefore has a different experience.  A lot of people report that Zomig will keep the attacks away for anywhere from 10 to 24 hours.  For me, it lasts no longer than trex.  Within an hour or so, I can get pummelled again after taking Zomig.  The trex injects works quicker for me and I do not have the same experience with feeling like crap and I don't get the so-called rebounds with trex that some people report.  Plus I don't have to fight the insurance company to get trex like I do Zomig.
Title: Re: Seeking your thought- Triptans
Post by Roxy on Sep 5th, 2005, 9:55pm
Hey Wendy, sounds like you and I have had some of the same thoughts.  At this point, I think there might be one triptan that I haven't used, but like everything else with clusters...YMMV.

I agree totally with your assessment of imitrex.  Yes, it worked, in under ten minutes, but I had more hits and felt like the floor of a nasty ass bar.  And I usually had to use two or more shots a night, then three or four during the day.  Once I stopped using trex, even the kids could tell a difference in me.

I used Relpax, starting at 5mg and quickly building to the 40 mg tablet over a period of three months.  Immunity seems to have built fast with this triptan, and there were breakthroughs.  I used this triptan as a preventative though.

I then moved on to Frova, twice a day, used as a preventative.  A different neuro saw what and how much I was taking, pulled me off the pills and wanted to know what idiot prescribed that for me.  I had the pleasure of telling him it was his partner.

Maxalt sucks.  Won't even get rid of a hangover.

Amerge has worked ok, some breakthroughs when used as a preventative.

My drug of choice now, and I wish like hell they made an injectable is Zomig.  The nasal, used to abort, will usually keep me PF for almost twelve hours.  So will the 5mg tablet.

None of the above triptans, excluding imitrex, seem to worsen my ch or leave me with the same nasty feelings as trex.  I think those that use trex do have their cycles worsened by the drug.  I didn't realized what was happening till I was off of the stuff.  I'm just glad it wasn't a permanent effect.

I am still convinced that if the drug companies realized the amount of triptans ch'ers use, they would change their tunes about producing what we need.  I'll never forget the look on the drug reps faces at NECH when we told them the amount of trex just used for Cat and I.  They really didn't have a clue and were shocked.  In one month, we used as much as most migraine patients use in a year.

Zomig nasals aren't quite as fast as trex, it will sometimes take up to 20 to 25 minutes.....sometimes it's only 10. Then sometimes I'll snort one before going out to dinner or a party and use it as a preventative instead.  But, I haven't found any adverse effects, and then I have the relief of knowing that I'm good to go for about 12 hours after using it.  I hoard my Zomig nasals like gold.  Right now, with my new insurance, I'm only getting 12 a month.

Sorry this got long winded....I tend to start ranting when talking about triptans.

T  8)  
Title: Re: Seeking your thought- Triptans
Post by pubgirl on Sep 6th, 2005, 2:44pm
Thanks for the great reply Roxy!


I think we share another problem, being female of a certain age and having migraine AND CH.

I am not posting in detail yet but am quite hopeful about my own personal Frova trial. Luckily my total gem of a GP gives me anything I want. Sorry your doesn't as although my experiment is in the early stages, provisionally I think it has real value for CH sufferers.

I still have my Imigran but it really is for emergencies only, bloody hate the stuff.

Wendy

P.S. Research yet to be released is that Zomig nasal trials show it as faster than Imi nasal but slower than Imi subcutaneous.
Title: Re: Seeking your thought- Triptans
Post by Gator on Sep 7th, 2005, 12:34am
I don't know about the clinical trials, but in my personal experience you are right, Wendy.  Trex injects are the fastest.  Zomig is much faster than trex nasal and a hell of a lot more effective in my case.

It would seem a no-brainer - Locally, Trex vials = $135.00  Zomig NS= $30 per.  Why in the world my insurance company would rather give me trex over Zomig is a mystery.  Well, not really.  GSK gives Aetna "incentives" to prefer trex.  It says so right on Aetna's website.  

BTW, good luck with the frova trial.
Title: Re: Seeking your thought- Triptans
Post by Roxy on Sep 7th, 2005, 11:16am

on 09/06/05 at 14:44:08, pubgirl wrote:
P.S. Research yet to be released is that Zomig nasal trials show it as faster than Imi nasal but slower than Imi subcutaneous.


About half of the time, Zomig nasal works as fast as the trex injection....on me.  First time I used the nasal, it worked in five minutes.  It's the other half of the time that's a sonofabitch.

One thing I noticed with the trex injections, and I know Mast noticed the same thing.  When you injected, it ramped you up damn fast, and then it was ten minutes of hell till it kicked in.  I guess Zomig has the same effect at times.

I very seldom use the Zomig when I'm at home, I always just rely on 02, but yesterday I had to use it.  Had a good one going that nothing would work on....02 wasn't touching it.  After using the nasal I stayed on the 02....and timed it.  Took three minutes, and even the remnants of pain were gone.  This was at 1:30pm, and that one nasal held me all night, and it's got to be strong stuff to hold me through the night.  Actually got some sleep for a change... ;;D.

Imitrex would only keep me PF for about an hour to an hour and a half after an injection.

Everyone always talks about the bad taste of the nasals......best taste in the world to me.

T   8)
Title: Re: Seeking your thought- Triptans
Post by pubgirl on Sep 8th, 2005, 5:23pm
Looks like we are getting some sort of consensus going here ;;D

Now I just want to know if there is any reason other than financial why the dreaded Trex is the only triptan available in injection form?

I want Zomig and Frova injectibles, or at least a Frova nasal.

But I bet I don't get it


Wendy
Title: Re: Seeking your thought- Triptans
Post by ozzy on Sep 9th, 2005, 10:02am
Wendy,

In the past we have talked about Verapamil and Imitrex, and how Imitrex in particular seem to supress hits until the drug wears off, only to retun later.

I am convinced that in my case Imitrex works temporarily and the the frequency of attacks increases. As you may have read (or not) Kudzu worked fantastically for me ... until it stopped being effective. Now I'm getting hit at least 4 times a day variying from k6 to k9. I have a case of Imitrex Nasal at home, untouched. I still remember the hell of getting hit every 2 hours 24 hours a day. Four hits doesn't seem to be bad in comparison. I'm getting my O2 again.


Will I go back to triptans. Gut feeling, no. But I can't be certain. I miss being episodic.

I hope this adds to the conversation.


Ozzy
Title: Re: Seeking your thought- Triptans
Post by Kris_in_SJ on Sep 9th, 2005, 8:32pm
I wish I had an answer to your question, Wendy.  I just tend to blame everything on the pharmaceutical companies.  I have noticed in the last few months that Glaxo has stopped advertising Imitrex as a drug for "Migraine Sufferers Only."

I consider my self lucky to be an every 3-4 year episodic who suffers exactly 2 CHA's a day at peak of cycle - 9 PM and 2 PM on the clock.  Trex is perfect for me.  If I start high-dose Verap at the beginning of a cycle, I rarely need Trex for longer than 3 weeks and have never had rebound effects.  However, it takes a DAMNED long time to wean of the Verap.

It seems to me that all we can do is put pressure on the companies that produce Zomig and other abortives to come up with an injectible form.  It will cost us of course!

I hate using Trex as much as you, and don't start using it until those kip 9-10's start kicking in.  I also stop using it once the side effects (burning all over, rapid heart rate, etc.) become more painful than the HA itself.  When I'm at peak, those particular side effects mean immediate relief and I'm grateful.  What a conundrum! (sp?)

Kris
Title: Re: Seeking your thought- Triptans
Post by E-Double on Sep 9th, 2005, 8:45pm
I have a closet full of trex that I try my hardest not to touch. I use it if absolutely desperate.

O2 is working the way it did and zyprexa though still effective is not as good as it was.

I don't think I would try another triptan at this point.

I deal with my ice and fingers like the old days plus my coping mechanisms are a lot better.

I definitely think that there has to be the capabilities to make injections of the other stuff though.
Title: Re: Seeking your thought- Triptans
Post by Gator on Sep 10th, 2005, 12:28am
Another question to ponder is if they were to make an injectible form of the Zomig or Frova, would they have to water it down in order to lessen the potential side effects?  If they did, would it be as effective as it is for some?
Title: Re: Seeking your thought- Triptans
Post by andredulak on Sep 10th, 2005, 12:34pm
A warm good morning, good afternoon or good evening to all as the case may be. I am new at this and this is my first post.

I am 53 years old and just experienced my second episode of CH (6 weeks) after the first one of the same duration four years ago.

From reading extensively the previous posts on this site, I realize that most of you might be envious and I certainly understand and sympathize!

I don't know if I am in the right "place", but I would very much love to have any possible feedback concerning the side effects of Imitrex.

I tried it this time, and only because I was able to convince my GP that I had CH (that was easy, as the neurological exams were conclusive 4 years ago) and that Imitrex was the treatment of choice (that is thanks to this website - thank you!).

My girlfriend, horrified at the pain I was going through, bought me 2 doses of injectable Imitrex (to this day, she refuses to say how she managed it, as it requires a prescription) and it worked fine.

My GP, after prescribing massive doses of OTC pain medicines, then prescribed Imitrex 50 mg tablets.

The pain usually took 40-50 minutes to go away.

The side effects, however, were absolutely horrendous.
I read the list on a GSK site and I believe I experienced them all : skin rash, eye pain, but mostly this "tingling" headache, which kept getting worse and worse, lasting for hours on end.  I seriously thought that I might have a brain tumor ...

My daily bouts (average duration 3 hours) stopped as suddenly as they appeared, after 6 weeks, and 12 Imitrex tablets. I even "skipped" taking my Imitrex during my last bout, for fear of the side effects.  I would rather hurt as hell for 2 to 3 hours rather than feel terrible all day long.

I have been CH free now for 18 days, and the side effects I experienced have disappeared  only very recently.

Thank God the beast is gone, and I hope it stays away for a very long time.

I also took Inderal 80 mg CR for 6 weeks, and I originally thought the side effects were due to it.

Would anybody care to detail his/her side effects, as I've read so many things about how Imitrex helps, but also how people "really hate it".

Thank you and excuse the beginner who might be in the wrong forum.

Any feedback will be greatly appreciated.

Thank you and God bless.

André Dulak, Wavre, Belgium.
Title: Re: Seeking your thought- Triptans
Post by LeLimey on Sep 10th, 2005, 1:38pm
Hello Andre
Welcome, I'm sorry you had to come looking for us.
Don't worry about being in the right or wrong place, we'll find you and help you and thats all that matters!
Hopefully your cycle has finished, 18 days PF is a very good sign and I'll be keeping my fingers crossed for you!

Imitrex tablets aren't usually considered effective for CH due to the extremely long time they take to kick in. The most common form of useage is the injections which will work in 5-10 minutes. However, given the side effects you experienced with the tablets I would be reluctant to attempt the injections if I was you! It is certainly something that you would need to discuss with your doctor. Have you any history of heart problems as triptans aren't the best way to go for people with heart disease or who have had heart attacks.
There are other triptans which are very effective and which you don't experience the same side effects with so it would be worth discussing your options with your doctor there. Zomig or Zolmitriptan nasal sprays have a very good history and recently people in the UK have been experimenting with Frovatriptan as a preventative and getting up to 12 hours relief at a time. Thats certainly worth considering!
What I'd really like to suggest though is that you try O2.
Breathing O2 through a non rebreather mask at 15 litres per minute is extremely effective and side effect free! I can abort a hit with O2 within about 5-10 minutes although I will admit to using a special mask (clustermasx.com)
Hopefully it will be at least four years until your next cycle and who knows what developments there will be by then so I'd certainly keep an eye out if I was you!
I hope this helps, keep reading, keep asking questions, its the only way to find the treatment that works best for us. By the way we do have another sufferer from Belgium on here, Ronny who lives in Brugge, it might be interesting for you both to compare notes on CH treatments available there!
Take care,
Helen  
Title: Re: Seeking your thought- Triptans
Post by Gator on Sep 11th, 2005, 7:09pm
Welcome Andre'

You say your doctor gave you the 50mg tablets and they made you feel like crap.  Is that the way the shot made you feel as well?

As long as your doctor has given you the okay to take the imitrex, try the injections.  If a full shot knocks out the attack, but leaves you feeling bad, try the imitrex tip over on the left.  Many of us find that 1/3 to 1/2 of the shot will work quite well.  It lessens the side effects and makes your trex last longer.

As far as I am concerned, trex tablets suck for CH.  I tried them and I feel like crap forever after taking one.  I do not get that with the injections.  I use 1/2 a shot and it knocks out the attack fast.

Good luck to you and wishing you many more pain free days and nights!

Mike
Title: Re: Seeking your thought- Triptans
Post by Ree on Sep 11th, 2005, 8:42pm
Have either of you girls (Roxy and Wendy) tried Neurontin as a preventative.  In years past when Dave would start his cycle.... he would rapidly build to a point where he would get hit and hit and hit.... this is his 3rd cycle on the Neurontin... I am probably jinxing him by saying this but.... he isn't getting hit over and over like cycles before the Neurontin...... I know it has different effects for different people.... and I also am not stupid or in denial.... I know each cycle comes a time when NOTHING WORKS.... and its like a peak time for him where he will be at his worse.... I just know the Neurontin has changed things for him big time..... Those zomigs are too too expensive and dangerous to your heart to use as preventatives.... I dont know about Frova or the Relpax..... Good luck and God Love ya    ree
Title: Re: Seeking your thought- Triptans
Post by cootie on Sep 12th, 2005, 10:39pm
I'm STILL confused.....I tell Brad what I read here and he tries to explain it to the doc or ask him for whatever MITE work better I have read bout on here. He got carried away with the imitrex tabs last cycle cuz he'd panic and didn't seem to know what a shadow was goin to do to him. The more tabs he took the more hits he got......that was 'my' observation on it all. Seems he was gettin hit left and right and not a pattern like they had started out MANY years ago for cycles. I told him I think the tabs were makein it worse but didn't know what else to tell him.....I'm by far no expert here and only a supporter so when he has a cycle comein on I can't tell him what to do......I can only try to get him to ask for stuff from the doc and hope he gets the doseage rite.....whatever. He has trex now but has never used it 'yet'......am hopein if he does he doesn't start gettin hit ten times more like last cycle with the injections ? Lets jus hope he skips anouther cycle......I just am not always sure I am adviseing him rite. Doc pretty much listens to what he wants to try with a few sudgestions of his own. He mentiond topomax last cycle and I about choked. I really reall REALLY don't think Brad could function on that stuff. He can't handle anything that makes him dumb or dopey.....he has alot of responsibility at work to work with figures and machines and measurements and get things perfect.....he can't be handicapped. OK.....jus keepin advised and up on things. Dumber of the dumbest Pam
Title: Re: Seeking your thought- Triptans
Post by jon019 on Sep 14th, 2005, 9:44pm
Holy God!

I have never heard this said before but have thought it a million times. The beast does seem to have a life of its own. Sometimes surrender is all that is possible. It will not go away with its pound of flesh NO MATTER WHAT!
At least it gives me "something" to hate.

PS I'm new at this so quoting is being guessed at, sorry if I did it wrong.

Regards

Jon019




[quote author=hwm54112 link=board=meds;num=1125566172;start=0#8 date=09/03/05 at 16:09:42]Glaxo has a patent.






Far-fetched idea? Before high doses of verapamil and sumatriptan, if I used 02 I would have a moderate CH for several hours, as long as I kept using the 02. If I did nothing, I would have a horrendous CH for 45 minutes. This was consistent for numerous headaches (daily for months on end). Could it be that the beast must deliver a certain amount of pain before it subsides?  Expressed mathematically, does 10 units of pain for 1 minute equal 1 unit of pain for ten minutes and then it subsides in either instance? Anything is possible.
Title: Re: Seeking your thought- Triptans
Post by Mr. Happy on Sep 14th, 2005, 10:12pm

on 09/14/05 at 21:44:33, jon019 wrote:
Holy God!
Praise Wotan!

on 09/14/05 at 21:44:33, jon019 wrote:
I have never heard this said before but have thought it a million times. The beast does seem to have a life of its own. Sometimes surrender is all that is possible. It will not go away with its pound of flesh NO MATTER WHAT
Aye, laddie.

on 09/14/05 at 21:44:33, jon019 wrote:
At least it gives me "something" to hate.
You haven't met my future ex, have you?

on 09/14/05 at 21:44:33, jon019 wrote:
PS I'm new at this so quoting is being guessed at, sorry if I did it wrong.
You fucked it up 9 ways from Sunday, but that's OK. It's meaningless, since you got your thought across.
Keep working on the O2 Yell if you need any cool O2 utils. I got your Six. Heh.


on 09/14/05 at 21:44:33, jon019 wrote:
Expressed mathematically, does 10 units of pain for 1 minute equal 1 unit of pain for ten minutes and then it subsides in either instance?
No.

on 09/14/05 at 21:44:33, jon019 wrote:
Regards
Best,
RJ
Title: Re: Seeking your thought- Triptans
Post by jon019 on Sep 15th, 2005, 10:36am
Mr. Happy,

Damn, that was funny. And of course I meant to say that Mr Beastie will not leave WITHOUT chunking off his pound of flesh.

And OK, how about a lesson in quoting as you so ably demonstrate (I was trying to quote hwm54112).

BTW, is there a hidden spell check in here somewhere. Billy Gate's "word" has turned what's left of my cluster f****d brain to mush.

Regards

Jon019
Title: Re: Seeking your thought- Triptans
Post by Cooked Brain on Sep 16th, 2005, 7:46pm

Relpax (1/2 a 40mg pill) usually keeps me safe through the night.

DHE is not a triptan.


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