http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl New CH.com Forum en-us New CH.com Forum Sat, 25 May 2013 04:48:42 GMT http://blogs.law.harvard.edu/tech/rss YaBB 2.4 Revision: 1.28 30 http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1366746778/6#6 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1366746778/6#6 Sat, 25 May 2013 04:13:49 GMT Jeannie, yes I've told all my docs about busting. Most were supportive in my choice, and like Bill, it was an off the record discussion. I'm hoping you've had complete success by now, but I did want to mention that sometimes mixing up the type of treatment works to really bust a cycle. PM me if you have any questions. <img src="http://www.clusterheadaches.com/yabbfiles/Templates/Forum/default/smiley.gif" border="0" alt="Smiley" title="Smiley" /> hugs<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369436113/2#2 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369436113/2#2 Sat, 25 May 2013 02:36:03 GMT Thanks for the reply Joe,<br /><br />I have discussed Verapimil with my Neurologist as it does seem to be the preventative of choice.  However my BP tends to already run low and he is not comfortable prescribing it.  I have finally adjusted to the cognitive side effects of the Topamax.  I will hit the 200mg dose this weekend. (  I am a big guy 200lbs, well I used to be. Have lost quite a bit of weight this cycle <img src="http://www.clusterheadaches.com/yabbfiles/Templates/Forum/default/sad.gif" border="0" alt="Sad" title="Sad" />.  I hope this dosage will keep the beast at bay. Or that the current prednisone taper will end the cycle.  Aside from the beast itself the right side facial pressure neck tension and in between CH headache fog is wearing me out.  <br />I will try the 15000 D3.  I am already taking 10000. I like most of us will try anything. <br /><br />Thanks again! http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369436315/0#0 New CH.com Forum/Meetings and Gatherings http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369436315/0#0 Fri, 24 May 2013 22:58:35 GMT Any CH sufferers in NYC know of any groups.  Meetings etc? http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369436287/0#0 New CH.com Forum/Meetings and Gatherings http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369436287/0#0 Fri, 24 May 2013 22:58:07 GMT Any CH sufferers in NYC know of any groups.  Meetings etc? http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369236385/9#9 New CH.com Forum/General Posts http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369236385/9#9 Fri, 24 May 2013 20:46:43 GMT I pretty much stopped eating processed meats and foods after I was diagnosed. We have an active farmers' market where I live, so I was able to get good free ranged chicken (I basically stopped eating red meat, except for bison which came from a farm locally). <br /><br />For you guys who enjoy a good laugh, checkout Thug Kitchen. It's got some great recipes that great humor.<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369425343/0#0 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369425343/0#0 Fri, 24 May 2013 19:55:43 GMT FRIGHT<br /><br />The familiar tingle begins<br />I deny<br />The beast descends, hideous, horrifying<br />I am a coward<br />The talons grip, twisting, stabbing<br />I am a coward<br />Burning me, as I rock and dance<br />I am a coward<br />"Why Me?", the beast just smiles, grips harder<br />I am a coward<br />I walk, miles, but I cant outpace him<br />I am a coward<br />My face is wet, sweat and tears, pouring.<br />I am a coward<br />I give up, "Kill me" I cry<br />I am a coward<br />Suddenly, the talons loosen, untangle, the beast lifts off<br /><br />I AM NOT A COWARD, <br />I AM BRAVE<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368904379/4#4 New CH.com Forum/Medications,  Treatments,  Therapies http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368904379/4#4 Fri, 24 May 2013 18:14:00 GMT <b><a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368904379/3#3">theAnthonyCarter wrote</a> on <b>Yesterday</b> at 11:26am:</b><br /><div>By the way, not sure you've seen this thread yet, but it might help...<br /><br />Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1368904379"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a> </div><br /><br /><br />Being a little bit biased, I assure you that thread will help <img src="http://www.clusterheadaches.com/yabbfiles/Templates/Forum/default/wink.gif" border="0" alt="Wink" title="Wink" /><br /><br />-Gregg in Las Vegas http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1358385067/104#104 New CH.com Forum/General Posts http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1358385067/104#104 Fri, 24 May 2013 16:10:18 GMT Jon...<br />Even though we don't know each other well I want you to know that my thoughts and prayers are with you on your difficult road. This is a wonderful family we have here and we have your back so keep talking and venting as we are ALL rooting you on and want to help as much as possible with support, caring and love for a family member...Take good care and keep fightin the good fight!!....<img src="http://www.clusterheadaches.com/yabbfiles/Templates/Forum/default/smiley.gif" border="0" alt="Smiley" title="Smiley" /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1365646904/7#7 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1365646904/7#7 Fri, 24 May 2013 15:23:20 GMT My first attack or 2 came when I was around 19 or so years old. At the time, I didn't go to the doctor since I'm just one of those types that doesn't go to the doctor "unless your dying." Well, of course the beast came back a few years later when I was 21 or so. THAT time I decided it's visit the doctor time because these things were just NOT normal. Something HAD to be wrong.<br /><br />At the time, I didn't have a "regular" doctor, so I just went to the local health center and saw whatever alternating doctor that they had there that particular day. She checked me out, and rather quickly "suggested" that it may be a "sinus infection." The funny thing is, she had to have been at least somewhat familiar with cluster headaches as she did mention that it "could be" cluster headaches. However, she still leaned towards the sinus infection diagnosis, probably because cluster headaches are generally perceived as quite rare. She then prescribed some antibiotics, and sent me on my way with little more than the statement that I should return if I had any more of these crazy headaches.<br /><br />Needless to say, I was back in there in a couple of days. The good news was that I saw a completely different doctor that day, and he immediately recognized this as a cluster headache attack. While I was there, he had the nurse inject me with my first Imitrex experience (which worked like a charm for me), and prescribed me Verapamil as a preventative. So, in the sense of getting a diagnosis fairly early on, I got "lucky," I guess. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1366757735/11#11 New CH.com Forum/Medications,  Treatments,  Therapies http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1366757735/11#11 Fri, 24 May 2013 13:07:20 GMT That's great news. There's a reason it's still the first line prevent as it has a great track record. Don't forget to up your fiber and fluid intake as it tends to REALLY slow down the digestive tract for many.<br /><br />Joe http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368512755/7#7 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368512755/7#7 Fri, 24 May 2013 05:36:50 GMT I dont know about other people I think everyone might do something different.  I dont know what thunderclap HA are, never heard of them.  Like most here though I know about pain.  I dont have O2 or imitrex injections, no insurance.  So when I get an attack I have to ride it out.  Sometimes I'll take a super crazy hot shower dont know why but it usually calms me down and I can ride out the most severe part of it.  Other times if that doesn't work I'll walk from the front of my house to the back as sitting still or laying down is not optional.  Sometimes I just get down on my knees hold my head and rock back and forth like I'm praying or something. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368731958/11#11 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368731958/11#11 Fri, 24 May 2013 03:58:11 GMT <b><a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368731958/10#10">Tommst wrote</a> on May 23^rd, 2013 at 2:45pm:</b><br /><div>I have not tried any other energy drink really because I *know* that coke works if you know what I mean. </div><br /><br />Understand what you mean in that you've something you know that works. Although the energy drink may work even better. Only by trying will you find out.<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369232089/9#9 New CH.com Forum/General Posts http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369232089/9#9 Fri, 24 May 2013 02:16:00 GMT <b>Quote:</b><br /><div>The Daniel/Annette saga was much, much more than just this. </div><br /><br />To say the least.<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369100437/5#5 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369100437/5#5 Thu, 23 May 2013 22:58:54 GMT Energy drinks can be surprisingly effective for me when chugged fast enough and soon enough, especially for nocturnal attacks. A good double-espresso will sometimes do wonders for daytime attacks, as long as there isn't a strong trigger present. <br /><br />I also always carry in my wallet a triptan in the form of soluble wafer. Almost as effective as shots. If the caffeine and/or taurin doesn't do the trick the triptan usually would, and the combination is clearly more effective. <br /><br />Luttle is known about taurin from what I read, but there are many taurin receptors in the hypothalamus which suggests that it actually effects the abnormality of hypothalamic activity.<br /><br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369268320/7#7 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369268320/7#7 Thu, 23 May 2013 22:39:17 GMT The D3 regimen certainly worth a try. Also, some really stubborn CH'ers react good to cannabis. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1344149471/16#16 New CH.com Forum/Medications,  Treatments,  Therapies http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1344149471/16#16 Thu, 23 May 2013 22:02:32 GMT After reading all these post's, it seem's to me, the jury's still<br />out on this one. I managed to stop smoking using E Cigarettes. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1367854932/3#3 New CH.com Forum/Medications,  Treatments,  Therapies http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1367854932/3#3 Thu, 23 May 2013 21:11:50 GMT <div>Hola Lulu,<br /><br />I keep the updates to the anti-inflammatory regimen and latest survey results at the following link:<br /><br />Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1367854932"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a><br /><br />Hope this helps.<br /><br />Take care and please keep us posted.<br /><br />V/R, Batch</div> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1311476333/18#18 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1311476333/18#18 Thu, 23 May 2013 15:20:55 GMT My "shadows" tend to be painless for the most part, at least physically. It's kind of like a feeling like the veins in the side of my head are already a bit "over-sized" and puffed up just ready to go into overload when the real deal sets in. It's like whatever the physical manifestations that cause the actual excruciating pain that we feel are, whether it is truly directly caused by the dilation of the vessels in our heads or not, my shadows are those things sitting at the borderline or tipping scale instead of where they SHOULD be if I were like every other "normal" human being. They're teetering like a see-saw just waiting to tip just a little too far, and then all HELL breaks loose! http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369274246/1#1 New CH.com Forum/Funnies and Jokes http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369274246/1#1 Thu, 23 May 2013 14:56:12 GMT <img src="http://www.clusterheadaches.com/yabbfiles/Smilies/confused.gif" border="0" alt="Smiley" title="Smiley" />  WTF http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1249056520/15#15 New CH.com Forum/Medications,  Treatments,  Therapies http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1249056520/15#15 Thu, 23 May 2013 14:26:31 GMT <b><a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1249056520/10#10">Joeytastic wrote</a> on Aug 1^st, 2009 at 7:00pm:</b><br /><div>UPDATE ON THIS<br /><br />Administrator - It took me ages to get my head around the trex tip intructions on the link tothe left. Can I suggest you get some pics up of the kit up in pieces? I think it would help a lot.<br /><br />  </div><br /><br />I realize this is an old post to quote, but I have created an illustrated PDF file that shows the steps to the Imitrex Tip. I have already contacted the original author of the tip to see what he thinks about possibly getting this posted up on the site for any others that may be new to the idea of manual injections.<br /><br />As soon as I hear something back, I'll let everyone know what's up. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369316293/1#1 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369316293/1#1 Thu, 23 May 2013 13:45:18 GMT I don't have any experience with that type of disorder. The following was posted here recently disputing the long held belief that CH was primarily a vascular disorder. Might be of interest to your cardiologist:<br /><br /><i>Interesting to note that he is saying that the primary mode of action is NOT as a vasoconstrictor but on its effect on the central nervous system. Doesn't change our appreciation of this class of meds but suggests we need to change how we think about the nature of CH. </i><br /><br />============================== <br />Handb Exp Pharmacol. 2007;(177):129-43.   <br /><br /><br />Serotonin receptor ligands: treatments of acute migraine and cluster headache. <br /><br /><br />Goadsby PJ. <br /><br />Institute of Neurology, Queen Square, London WC1N 3BG, UK. peterg@ion.ucl.ac.uk <br /><br />Fuelled by the development of the serotonin 5-HT(1B/1D) receptor agonists, the triptans, the last 15 years has seen an explosion of interest in the treatment of acute migraine and cluster headache. Sumatriptan was the first of these agonists, and it launched a wave of therapeutic advances. These medicines are effective and safe. Triptans were developed as cranial vasoconstrictors to mimic the desirable effects of serotonin, while avoiding its side-effects. IT HAS SUBSEQUENTLY BEEN SHOWN THAT THE TRIPTANS' MAJOR ACTION IS NEURONAL, WITH BOTH PERIPHERAL AND CENTRAL TRIGEMINAL INHIBITORY EFFECTS, AS WELL AS ACTIONS IN THE THALAMUS AND AT CENTRAL MODULATORY SITES, SUCH AS THE PERIAQUEDUCTAL GREY MATTER. Further refinements may be possible as the 5-HT(1D) and 5-HT(1F) receptor agonists are explored. Serotonin receptor pharmacology has contributed much to the better management of patients with primary headache disorders. <br /><br />PMID: 17087122 [PubMed] <br />=================================================================<br />J Clin Neurosci. 2010 Mar 11. <br /><br />What has functional neuroimaging done for primary headache ... and for the clinical neurologist?<br />Sprenger T, Goadsby PJ.<br /><br />UCSF Headache Centre, Department of Neurology, University of California, 1701 Divisadero St, Suite 480, San Francisco, CA 94115, USA.<br /><br />Our understanding of mechanisms involved in primary headache syndromes has been substantially advanced using functional neuroimaging. <br /><br />THE DATA HAVE HELPED ESTABLISH THE NOW-PREVAILING VIEW OF PRIMARY HEADACHE SYNDROMES, SUCH AS MIGRAINE AND CLUSTER HEADACHE, AS BRAIN DISORDERS WITH NEUROVASCULAR MANIFESTATIONS, NOT AS DISORDERS OF BLOOD VESSELS. <br /><br />PMID: 20227279 [PubMed]<br /><br />Hope this is helpful.<br /><br />Joe<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368677815/14#14 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368677815/14#14 Thu, 23 May 2013 04:24:55 GMT great news, here's hoping it continues!<br /><br />Joe http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1242417046/55#55 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1242417046/55#55 Thu, 23 May 2013 03:29:04 GMT ok, so, I have been having clusters since I was 18, 38 years ago, and had to post something on here as if it saves one person a single headache is worth it. <br />These  headaches are evil and devious, what works one season, may not work the next, verapamil worked like a charm first time I used it, didn't work after that , has to do where the cycle is and how to interrupt it. mary Jane may work for some people I say try it , try anything that may help, amitriptiline, verapamil, sumatrapin has always worked to stop the attack, but not interrupt the cycle. nasal irrigation worked 2 years for me, then stopped working, mushrooms or lsd has been studied lately as it seems to work to stop the cycle and thats really what its all about stopping the cycle.<br />if you have a headache that ibuprofen stops , you dont have a migraine much less a cluster, imitrex injections or nasal spray stop the attack the fastest in my opinion, but don't stop the cycle, I have tried everything there is to try, and <br />have to change it almost every cycle, as the same thing won't work more than two times, but the imitrex or generic sumatrapin always stops the attack.<br />I have stopped the cycle by changing where I was physically, taking a plane ride somewhere going into the mountains, anything that makes your ears pop may also do the trick. <br />avoiding the cycle, I have never found anything that works, except when I took amitritiline, for a year, skipped a year , mine always come in march or april depending on climate, may be pollen counts or something, but once started will go on and on for months sometimes till I can break it, am currently going on two months of this cycle and started amitrip again.One year , during a horrendous attack, tried the nasal irrigation and it stopped immediately, like magic. Hope this helps someone <br /><br /><br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369268649/0#0 New CH.com Forum/Medications,  Treatments,  Therapies http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369268649/0#0 Thu, 23 May 2013 00:24:09 GMT Hi to all,<br /><br />As most here know CH and Migraine a common therapeutic target - CGRP release. To all those (like me) who had their heart broken when CGRP receptor antagonist medications fell over. I'm sure the significance of this will not be lost on CHers. "Spill over" from Migraine research means that in my town I may get a "shot" at this, through the right ethical and appropriate use channels, of course. The promise of a once a month vaccination against CGRP release gives me much hope.<br /><br />Enjoy!<br /><br />Cheers, Ben.<br /><br />Link: Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1369268649"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a><br /><br /><b>Alder BioPharmaceuticals Inc. Initiates Phase 1 Clinical Study of Antibody Therapeutic Candidate for Treatment of Migraine, ALD403</b><br /><br /><b>Therapeutic Targets Well-Validated Biology through Inhibition of Calcitonin Gene-Related Peptide (CGRP)</b><br /><br />BOTHELL, Wash., May 7, 2012 /PRNewswire/ -- Alder BioPharmaceuticals Inc. today announced the initiation of a Phase 1 clinical study of its antibody therapeutic candidate, ALD403, targeting the calcitonin gene-related peptide (CGRP) for treatment of migraine.<br /><br />The placebo-controlled, single ascending-dose study will evaluate the safety and tolerability of ALD403 administered via both intravenous infusion and subcutaneous injection.<br /><br />Healthy volunteers will be enrolled in the study and followed for 12 weeks following the treatment. In addition to the primary endpoints of safety and tolerability of the two formulations of ALD403, the study will also evaluate the pharmacokinetic and pharmacodynamic profiles of the treatment in the healthy volunteers.<br /><br />"There is a significant need in patients who experience migraines on a routine basis to have a convenient treatment that can prevent the migraine before it starts," said Randall Schatzman , Ph.D., president and chief executive officer of Alder BioPharmaceuticals. "We see distinct promise in ALD403 to meet this need given its potency and specificity for CGRP, which has been established as a validated target in migraine. ALD403 is manufactured with our Mab Xpress technology which allows us to mass produce the antibody for large markets, such as migraine and to rapidly achieve proof of concept.<br /><br />Research has shown that CGRP has a role as a trigger for migraine attacks, and inhibiting the peptide has demonstrated promise in preventing the onset of migraines. ALD403 is expected to be developed for patients experiencing multiple migraines per month with self-administered infrequent dosing.<br /><br />Alder's core technology enables the production of antibodies in very high quantities with improved cost structure via their Mab Xpress technology, allowing this class of therapeutics to enter disease areas that have previously been inaccessible for antibodies, such as migraine and cardiovascular disease. Proof of concept for this technology was achieved with ALD518, a monoclonal antibody to the pro-inflammatory cytokine IL-6, which is currently under Phase 2 development by Bristol-Myers Squibb for autoimmune diseases (BMS-945429), while Alder is developing the antibody for cancer-related conditions.<br /><br />About Alder BioPharmaceuticals<br /><br />Alder BioPharmaceuticals Inc. uniquely identifies, develops and manufactures novel antibody therapeutics to alleviate human suffering in cancer, pain, cardiovascular and autoimmune and inflammatory disease areas. The company's investigational monoclonal antibody for migraine, ALD403, inhibits a well-validated molecule shown to trigger migraine attacks, calcitonin gene-related peptide (CGRP), and is now in clinical trials. ALD518 is Alder's investigational monoclonal antibody to the pro-inflammatory cytokine IL-6. Alder is developing ALD518 in Phase 2 clinical studies in multiple cancer-related conditions, while Bristol-Myers Squibb is investigating the asset (as BMS-945429) in a Phase 2b clinical study in rheumatoid arthritis and other autoimmune indications based on a 2009 partnership. <br /><br />Alder's management team combines decades of industry experience with a proven track record for identifying and developing novel antibody therapeutics and enabling partners through the out-licensing of its technologies. For more information, visit Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1369268649"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a>.<br /><br />Alderbio's page on CGRP antibody in Migraine:<br />Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1369268649"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a><br /><br />Phase 2 trial dosing: Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1369268649"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a><br /><br /><b>First Patients Dosed in Proof-of-Concept Clinical Study of Alder Biopharmaceuticals’ Lead Therapeutic Candidate for Treatment of Migraine, ALD403<br />March 20, 2013</b><br /><br /><b>Company that Discovered and Developed Clazakizumab, Previously Known as ALD518, Advances New Program into Phase 2 Study</b><br /><br />BOTHELL, Wash., March 20, 2013 /PRNewswire/ — Alder Biopharmaceuticals Inc. today announced the dosing of the first patients in a proof-of-concept Phase 2 clinical study of its antibody therapeutic candidate, ALD403, targeting calcitonin gene-related peptide (CGRP) for treatment of migraine.<br /><br />The double-blind, placebo-controlled, randomized study will evaluate the safety and efficacy of ALD403 administered monthly. One hundred and sixty patients with frequent, episodic migraines will be enrolled in the study across six sites for six months. Patients in the study will have experienced between four and 14 migraines per month in at least three months prior to enrollment and take acute migraine medication.<br /><br />“Despite the enormous progress made in acute treatments for migraine, substantial unmet needs remain for patients experiencing multiple migraines per month,” said Richard Lipton, M.D., principal investigator, professor of neurology and epidemiology at Albert Einstein College of Medicine in Bronx, New York, and director of the Montefiore Headache Center. “Most currently available preventive treatments for migraine are taken on a daily basis, reduce migraine frequency by 50 percent in about half of users and often produce significant side effects. A biologic targeting CGRP and offering higher rates of efficacy, along with less frequent dosing and fewer side effects, could have a tremendous benefit for patients.”<br /><br />Added Randall Schatzman, Ph.D., president and chief executive officer of Alder Biopharmaceuticals, “Alder is changing the paradigm for the treatment of migraine from abortive care at the time of migraine onset to a preventative approach, and our team has developed a highly specific therapeutic candidate with the potential to prevent the disorder before it begins that we believe has the ability to make a large impact in migraine. This preventative approach has been welcomed by patients, evidenced by the significant patient interest at all of our trial sites, and we are proud to advance ALD403 into a proof-of-concept trial while exploring additional applications for our core technologies with therapeutic candidates in other disease areas.”<br /><br />Research has shown that CGRP has a role as a trigger for migraine attacks, and inhibiting the peptide has demonstrated promise in preventing the onset of migraines. ALD403 is expected to be developed for patients experiencing multiple migraines per month with self-administered infrequent dosing.<br /><br />Alder’s core technology enables the production of antibodies in very high quantities via its Mab Xpress technology, allowing this class of therapeutics to enter disease areas that have previously been inaccessible for antibodies, such as migraine and cardiovascular disease. Proof of concept for this technology was achieved with clazakizumab, previously known as ALD518, a monoclonal antibody to the pro-inflammatory cytokine IL-6, which is currently under Phase 2 development by Bristol-Myers Squibb for autoimmune diseases (BMS-945429), while Alder is developing the antibody for cancer-related conditions.<br /><br />About Alder Biopharmaceuticals<br /><br />Alder Biopharmaceuticals Inc. uniquely identifies, develops and manufactures novel antibody therapeutics to alleviate human suffering in cancer, pain, cardiovascular and autoimmune and inflammatory disease areas. The company’s second therapeutic program, an investigational monoclonal antibody for migraine, ALD403, inhibits a well-validated molecule shown to trigger migraine attacks, calcitonin gene-related peptide (CGRP), and is now in clinical trials. Clazakizumab, previously known as ALD518, is Alder’s investigational monoclonal antibody to the pro-inflammatory cytokine IL-6. Alder is developing clazakizumab in Phase 2 clinical studies in multiple cancer-related conditions, while Bristol-Myers Squibb is investigating the asset (as BMS-945429) in a Phase 2b clinical study in rheumatoid arthritis and other autoimmune indications based on a 2009 partnership. Alder’s management team combines decades of industry experience with a proven track record for identifying and developing novel antibody therapeutics and enabling partners through the out-licensing of its technologies. For more information, visit Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1369268649"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a>.<br /><br />CLINICALTRIALS.GOV: Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1369268649"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a><br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369055378/17#17 New CH.com Forum/Medications,  Treatments,  Therapies http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369055378/17#17 Wed, 22 May 2013 17:23:27 GMT I've said it before and rest assured I'll say it again Batch:  <img src="http://www.clusterheadaches.com/yabbfiles/Smilies/bow.gif" border="0" alt="Smiley" title="Smiley" /> <img src="http://www.clusterheadaches.com/yabbfiles/Smilies/bow.gif" border="0" alt="Smiley" title="Smiley" /> <img src="http://www.clusterheadaches.com/yabbfiles/Smilies/bow.gif" border="0" alt="Smiley" title="Smiley" /><br /><br />You sir, are the man.<br /><br />Joe http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369191441/8#8 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369191441/8#8 Wed, 22 May 2013 17:20:06 GMT And after I asked you where you were from I noticed your post..........Hello from Denver....sheesh...what little I ever had I'm losing!!!! <img src="http://www.clusterheadaches.com/yabbfiles/Templates/Forum/default/cheesy.gif" border="0" alt="Cheesy" title="Cheesy" /><br /><br />Joe http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369209899/0#0 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369209899/0#0 Wed, 22 May 2013 08:04:59 GMT Hi everyone,<br /><br />I was pretty active here a couple years ago. Am starting up the Vitamin D3 regimen again, so thought I would come back and catch up on the latest news.<br /><br />My screen name used to be ReneeM, but have changed it to Moxie Girl, so it is in sync with my account on the 'other' board. <br /><br />From what I remember, Batch likes to call, what most of us call the D3 or Vitamin D3 Regimen, the Anti-inflammatory Regimen. Not out to step on anyone's toes, or upset Batch, whom I have the greatest respect for, but I was playing around with a list of the ingredients last night, and came up with this.<br /><br />MOCKZiD3<br /><br /><b><div>M</div></b>agnesium<br /><b><div>O</div></b>mega 3<br /><b><div>C</div></b>alcium<br />Vitamin <b><div>K</div></b><br /><b><div>Zi</div></b>nc<br />Vitamin <b><div>D3</div></b><br /><br />At the very least, it will help me remember all the ingredients when I go to the store. <br /><br />MG<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368718278/3#3 New CH.com Forum/General Posts http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368718278/3#3 Wed, 22 May 2013 02:01:32 GMT What Mike and Brew said!  They could not have said it better!<br /><br />There are many of us who have had CH for years, but have been able to go on and live productive lives and do our jobs.  Some of us have had to make allowances and make some changes in what we do, but I don't see that being an issue for you.  As Mike said, let the people you work with know and step out, deal with it, and go back to work.<br /><br />I would also suggest you go to Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1368718278"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a> and check it out.  It has been life-changing for many.<br /><br />In Sept there will be a Clusterbusters convention in Rosemont IL (Chicago area) that will be of tremendous value to you even if you don't choose to go the alternative route.  There is a lot of education plus you get a chance to meet a lot of other clusterheads and get the concept of 'I'm the only one" out of your mind.  It isn't as bad as it used to be since this site came online and esp. since FB, but CH can be a lonely world when you don't know anyone who understands you.  (Usually including your Dr.)<br /><br />Jerry http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1076441006/344#344 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1076441006/344#344 Wed, 22 May 2013 00:42:35 GMT Hello everyone.  I'm new to the site and thought I'd introduce myself.  <br /><br />I would like to say I used to have cluster headaches all the time.  So bad, in fact, they'd knock me off my feet at times.  <br /><br />However, I found getting a divorse really helped.  A lot less stress (I found mine increased with stress).  <br /><br />Then, I also had 2 neck fusions of my c4-c5 and c6-c7.  After the fusions they all but vanished.  I still get them all the time.  However, now they no longer feel like a spike rammed through my eye to the back of my skull.  Instead they feel like little needle.  Almost enjoyable to be honest with you.....compared to the previous.<br /><br />I also found the more Garlic I had in my diet the less frequesnt the headaches.  Maybe that was it.  Mt ex hated me cooking with Garlic.  Hmmmmmmm.....<br /><br />Anyhow, just thought I'd share.  Nice to be here. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1364344110/12#12 New CH.com Forum/General Posts http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1364344110/12#12 Tue, 21 May 2013 11:58:59 GMT <b><a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1364344110/8#8">LasVegas wrote</a> on Mar 29^th, 2013 at 3:09am:</b><br /><div>I think the emotional stress that CH's create upon us are actually a reason why so many CH'ers do smoke, and drink alcohol, and have compulsive behaviors.  <br /> </div><br />A broken hypothalmas plays a part in clusters headaches. The hypothalmus also plays a part in habits, additictions and compulsive behaviors.<br />Is there a connection? I have no idea. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369016857/3#3 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1369016857/3#3 Tue, 21 May 2013 11:57:11 GMT The only thing I would add to Mike's post is we often find a combination of energy drinks (Red Bull, Monster, Rock Star etc) coupled with high flow O2 (minimum 15lpm, 25lpm is better) and a nonrebreather mask works wonders. It does for me. Chug a double Monster at the first sign of an attack, grab the O2 mask, and within 3-5 minutes I have full abort. Used to take 25-40 minutes so a huge difference. Let us know how you make out. Blessings. lance http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1227043359/43#43 New CH.com Forum/General Posts http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1227043359/43#43 Tue, 21 May 2013 09:39:48 GMT I feel this story I'm 27 been getting CH for about 10 years now.  I also tried lots of medication that wasn't helping and I hate to say this but I was heavily addicted to heroin.  I thought it was the only thing that could help me out with headaches but it never did and by that time it was to late I couldn't stop.  I've been clean now for some time and have come to the conclusion that there is no opiate that is going to help.  I urge anyone who is taking opiates for CH to find something else they really dont help.  If your getting up to 10 or so CHs a day like I was you'd be hooked in no time.  Then you gotta deal with the CHs and keeping the meds flowing.  Super rough battle <img src="http://www.clusterheadaches.com/yabbfiles/Templates/Forum/default/cry.gif" border="0" alt="Cry" title="Cry" /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1366909762/8#8 New CH.com Forum/General Posts http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1366909762/8#8 Tue, 21 May 2013 09:21:07 GMT When it comes to pain I feel I'm a pretty tough guy.  I've done extreme sports all my life and other stupid stunts and got hurt pretty bad.  I tell you though, CH pain is so intense and out of the world.  No crash or accident I've ever had was nearly as painful as a CH.  Why oh why cant they find a cure!!! <img src="http://www.clusterheadaches.com/yabbfiles/Templates/Forum/default/angry.gif" border="0" alt="Angry" title="Angry" /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368973653/9#9 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368973653/9#9 Mon, 20 May 2013 17:02:30 GMT Thanks guys!<br />I signed up to OUCH straight away. Lots of help and support on there. <img src="http://www.clusterheadaches.com/yabbfiles/Templates/Forum/default/smiley.gif" border="0" alt="Smiley" title="Smiley" /> <br /><br />I was just wondering, how have cluster headaches affected your work? I have taken 2 days of one each week last week and will probably be off tomorrow as well <img src="http://www.clusterheadaches.com/yabbfiles/Templates/Forum/default/sad.gif" border="0" alt="Sad" title="Sad" /> I am getting stressed about it! http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1291969416/1421#1421 New CH.com Forum/Medications,  Treatments,  Therapies http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1291969416/1421#1421 Mon, 20 May 2013 13:59:36 GMT I find it frustrating not knowing the true potency of the vitamins considering FDA does not regulate.   <br /><br />Unless one gets repeat tested, it's all speculation how good it truly is.  With that stated, I prefer to pay a bit extra for reputable name brands that have been around for 20+ years.   <br /><br />-Gregg in Las Vegas http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368392478/2#2 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368392478/2#2 Mon, 20 May 2013 11:14:21 GMT Welcome to the board, what part of this world you hail from? You have a decent doc who understands headaches? An effective treatment regimen? Glad you stuck your head in hope we can help ya  abit.<br /><br />Joe http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368354307/5#5 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368354307/5#5 Mon, 20 May 2013 10:01:47 GMT If I miss a dose of verapamil, I'm sure to pay in pain. It doesn't happen very often, maybe once or twice a year because the consequences are so severe. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1363214830/13#13 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1363214830/13#13 Mon, 20 May 2013 08:26:58 GMT In Nigel's post he gives a very good description of a shadow. It's more a warning of what's to come without the full intensity of the pain. There are also a lot of us lefties out there, although for some it changes from cycle to cycle. I've been a member of the sinister gang for about 30 years. There is a post on the site with the results of a headache survey that will give you a lot of information, too. Good luck taming the beast. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1159993470/48#48 New CH.com Forum/Supporter's Corner http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1159993470/48#48 Sun, 19 May 2013 20:34:07 GMT There is also a half way point too. I like my supporter to be around, making sure I've got my O2 going but just letting me get on with it. During the CH I don't want to be fussed but I don't want to be totally alone either.<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1364761627/12#12 New CH.com Forum/General Posts http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1364761627/12#12 Sun, 19 May 2013 20:20:05 GMT Looks good to me John.  Let me know when they are available.<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368881713/3#3 New CH.com Forum/General Posts http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368881713/3#3 Sun, 19 May 2013 20:15:11 GMT If you are in the UK, sorry, I have no idea.  In the US, there is no listing in the social security blue book for headache disorders.  You have to get a diagnosis for depression, anxiety, and suicidal tendencies in order to get disability.  A group of us were in Washington in April with an event called "Headache on the Hill" (HOH 2013).  We were asking for headache disorders to be included in the listing of disabilities.  Check it out on facebook.  You will find lots of information and help there.<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1351967224/71#71 New CH.com Forum/Medications,  Treatments,  Therapies http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1351967224/71#71 Sun, 19 May 2013 15:40:23 GMT Just went through a week where I got hit 5 days in a row after switching D3 brands to a cheaper discount brand and paid for it after 191 days CH free on the regimen.<br /> I have seen that there have been some tests done in Europe on different brands of D3 and some are grossly deficient in the actual amount of D3 in them. My recommendation is to use a reputable brand such as Batches recommended "Kirkland" brand from Costco or I take "Natures Made" brand and "GNC" is another good one that comes to mind as i know several folks using it with good results. <br />The brand I switched to that was obviously deficient was "Rite aid" brand but may have just been a fluke?? I don't know for sure but about 8 days after switching from Natures made to the Rite aid brand is when I got hit.<br /> I had the opportunity to bust so i did and have been CH free for a week now and have not restarted the D3 regimen to see if it was the busting that worked and it appears that the busting has worked and I am going to give it some time to see if the CH free effects will continue but have all intentions to continue the D3 regimen for the great benefits that it has regardless of being CH free as I have no doubt that the regimen will continue to keep me CH free and feeling good!...<img src="http://www.clusterheadaches.com/yabbfiles/Templates/Forum/default/wink.gif" border="0" alt="Wink" title="Wink" /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368927561/3#3 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368927561/3#3 Sun, 19 May 2013 14:41:29 GMT 1. Are you seeing a qualified doc, one who has experience in treating complex headache disorders? If not, relying on our guesses is not the route to relief.<br /><br />2. It's possible that an increase in Verap would help but, again a decision to be made my a competent doc.<br /><br />3. The nasal spray version is the least reliable form and, if you delay using it until the attack has fully developed and/or gone on for some time before using it, will assure failure.<br /><br />4. Until you are using your present treatments effectively, changing treatments may only be walking away from meds which have been partly effective. Reconsidering your dosing and technique would be a wiser firs step. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368778466/5#5 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368778466/5#5 Sun, 19 May 2013 14:10:46 GMT You could very well be experiencing a form of cluster-lite, if there is such a thing. Do know this, however- you will know if you get hit with a K-9 or K-10. Here's hoping that you never do <img src="http://www.clusterheadaches.com/yabbfiles/Templates/Forum/default/wink.gif" border="0" alt="Wink" title="Wink" /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368899574/3#3 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368899574/3#3 Sun, 19 May 2013 13:35:45 GMT Welcome to the board Kemi. Is your husband working with a headache specialist neuro yet? We have seen the best results from doing so. As Bob mentioned, there are hundreds of headache types, some which mimic CH, and it’s important to eliminate those before arriving at a firm diagnosis. I’ve had CH for over 35years, they haven’t killed me yet! You need an organized approach to managing them so they don’t manage your life. I use a 3 pronged approach, many use a similar approach. But first and MOST IMPORTANTLY<br /><br />Follow this link to the medications section of this board and read the post  <br /><br />Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1368899574"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a><br /><br /> It’s a vitamin/mineral/fish oil supplement, all over the counter stuff. It’s up to an 81% success rate of those who try it and respond to the survey so you’re just shooting yourself in the foot if you don’t give it a shot. I’m 3 years pain free on it after a 35 plus year track record with episodic CH. Best of all, it’s healthy for you even without CH!<br /><br /><i>As of January 20, 2013, the compiled raw data indicates an efficacy of 80%. 240 out of the 300 CH'ers who have started this regimen and stayed on it for a month or more have experienced a significant reduction in the frequency and severity of their CH... 78% of the 300 CH'ers experienced a pain free response and 60% of the 300 have remained essentially pain free. Episodic and chronic CH'ers respond to this regimen at roughly the same rate.<br /><br />Preliminary survey results indicate most of these CH'ers were pain free before the end of the third week with some responding in a little as 12 to 24 hours. The average time to respond is five days</i><br /><br />So all that follows will be worthless I hope……….but still…<br /><br />1: A good prevent med. A med I take daily, while on cycle, to reduce the number and intensity of my attacks. I use lithium, it blocks 60-70% of my attack. Verapamil is the most common first line prevent, topomax also has a loyal following. Some have to combine lithium and verapamil together to get relief.<br /><br />2: A transitional med. Most prevents will take up to 2 weeks to become effective. I go on a prednisone taper, from 80 mg to zero over a two week period to give me a break while my prevent builds up. Prednisone will provide up to 100% relief for many CH’ers but is harsh on the system and should only be used for short periods of time. <br /><br />3: An abortive therapy, the attack starts, now what? Oxygen should be your first line abortive. Breathing pure 02 will abort an attack for me in less then 10 minutes, that’s completely pain free. Read this link as it must be used correctly or it will not work<br /><br />Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1368899574"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a><br /><br />This link will show you how to get set up with welding oxygen:<br /><br />Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=login;sesredir=num~1368899574"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/login.png" alt="Login" title="Login" border="0" /></a> or <a href="http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?action=register"><img src="http://www.clusterheadaches.com/yabbfiles/Buttons/English/register.png" alt="Register" title="Register" border="0" /></a><br /><br />Imitrex nasal spray and injectables are very effective abortives. I use the injectables, they’re expensive, and I rarely use them, mostly just when I get caught away from the oxygen. The pill form generally works too slow to be effective for CH’ers. <br /><br /><br />For now, get some energy drinks. Rock Star, Monster, any containing the combo of caffeine and taurine, have him chug it down as fast as he can when he feels an attack starting. Many can abort or at least really reduce an attack using these.<br /><br />Finally, visit our sister board for “alternative” treatment methods outside of mainstream medicine. As you’ll see from all the success stories on this board, there is something to it.<br /><br />clusterbusters.com<br /><br /><br />Bless your heart for being a supporter. My wife found the original CH streaming board many many years ago and saved my sanity! You supporters have a special place in our hearts. Read everything you can on this board, if your husband is a CH’er, knowledge is your best ally. We’ll help you all we can.<br /><br />Joe<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1357234272/29#29 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1357234272/29#29 Sun, 19 May 2013 10:12:48 GMT The hung-over (or strung-out) feeling, as you can see from the numerous posts in this thread, is fairly common among CH sufferers. In addition to the fatigue and malaise I can get tenderness on the skin where the headache was. In a very severe hit, I can be tender for days after. These things are nasty business, as your long and hard experience tells you. They are physical and mentally exhausting, not matter what kind of physical condition you're in. The good news is there are some good tips to minimize the damage and even eliminate some hits. Good luck. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368163983/7#7 New CH.com Forum/Getting to Know Ya http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368163983/7#7 Sun, 19 May 2013 09:33:31 GMT Keep your head up Rod, your journey with the Beast is just beginning. for some it's easier than others. Sounds like you're having a really rough time. I hope it eases off for you sooner, rather than later. You are most definitely not alone. There are tens of us. lol We're a rare breed, but we fight hard. There is always new information coming to light and even though not a lot of resources get expended trying to solve our condition, there are some out there working to end the dance. It seems like you have some good support and that is worth a lot. Good luck and God bless. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368734515/3#3 New CH.com Forum/Cluster Headache Specific http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368734515/3#3 Sun, 19 May 2013 00:01:38 GMT Hi Elizabeth<br /><br />I agree with what Joe and Bob have posted.<br /><br />CH can change with some people having sides switch or even the position on one side change. I know it freaked me out the first time that happened as it took me out of my comfort zone. Similarly it isn't unusual to find what worked one cycle doesn't work as well the next.<br /><br />However any time there is a significant change it is always best to seek expert advice. It is probably nothing, but well worth validating that.<br /> http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1348592528/6#6 New CH.com Forum/Meetings and Gatherings http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1348592528/6#6 Sat, 18 May 2013 19:19:48 GMT just moved to austin. http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368824149/0#0 New CH.com Forum/Funnies and Jokes http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1368824149/0#0 Fri, 17 May 2013 20:55:49 GMT Mrs Cameron a primary school teacher, was teaching her class<br />about the difference between right and wrong.<br /><br />"All right children let's take an example," Mrs Cameron said.<br />"If i were to get into a man's pocket and take his wallet with<br />all his money, what would i be?"<br /><br />Little Tony raises his hand, and with a confident smile say's,<br />"you'd be his wife."