I know that nitroglycerin is an instant trigger for CH, and that it is made in small amounts in the human body.  It also breaks down into Nitric Oxide which causes smooth muscle relaxation and blood vessel expansion.  It is the release of Nitric Oxide that Viagra generates for men with ED which I understand can also be a trigger for CH.  My question is this then, Could it be a development and release of NO that causes CH attacks? 

This thinking was brought on by doing some reading on Dr Ignarro's work on NO and the cardiovascular system.  I'm looking for something to replace statins for cholesterol, but this is causing second thoughts about pursuing NO. 

I don't recall having read anything about NO being involved with CH, but that means nothing.  Would one of you more learned ones please weigh in on this?

I may be barking up totally the wrong tree, but it made sense to me.  (Be warned)

Thanks much.

Jerry

Jerry:

Ask your Doc about Niacin:
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Lots of other articles out there.

Other than the flushing effect, there really are no side effects and I've not had any problems while in cycle.

Doug

Callico wrote on Oct 14^th, 2010 at 10:00pm:

I don't recall having read anything about NO being involved with CH, but that means nothing.  Would one of you more learned ones please weigh in on this?

I'll crash in anyway, which of course won't help with your situation.   :)


Quote:

I'm looking for something to replace statins for cholesterol

Quote:

Could it be a development and release of NO that causes CH attacks?

We observed a higher phenotype frequency of this allele in our control group compared with rates in control groups of other studies, whereas the frequency in our patients was similar to that in controls from previous reports. Thus, we conclude that it is unlikely that genetic variations within the NOS genes contribute greatly to cluster headache susceptibility.

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also same as abstract from: Analysis of Nitric Oxide Synthase Genes in Cluster Headache
Cephalalgia November 2002 22: 758-764,



Nitric oxide (NO) may participate in the mechanisms underlying vascular headaches, such as migraine and cluster headache ...

... but other factors are likely to render CH patients hyperresponsive to NO, and ultimately to cause the occurrence of pain and associated features.

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a neurovascular model could be more precise considering some recent experimental and clinical research data as serotoninergic neuromediation involvement, nitric oxide one and a possible genetic predisposition.

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wrote on Oct 27^th, 2010 at 8:07am:

Hi Jerry I found something about CH and NO. START PRINTPAGEMultimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to or END PRINTPAGE

Howdy, Neils.   ;)  Nice blog.

Best,

George

Neils meet Timothy. You guys need a meet-n-greet for a really long walk in the sun.

     Potter

wrote on Oct 27^th, 2010 at 8:07am:

Hi Jerry I found something about CH and NO. START PRINTPAGEMultimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to or END PRINTPAGE

Just curious, Neils...what part of "found" is "I wrote it myself"?

Best,

George

wrote on Oct 27^th, 2010 at 4:27pm:

Hi I just got a mail from Niels. He has been CH free for almost 2 years after taking 200 µg vitamin D3 and 500 mg magnesium chloride pr. day. Before starting supplementing he had about 140-200 CH days pr. year since 1990.  :)

     Do you hear voices in your head?

                       Potter

       

Roses are red,
Violets are blue,
I'm schizophrenic,
And so am I!!! ;D

I kill myself, really I do!!!!!

Joe

Guiseppi wrote on Oct 27^th, 2010 at 4:51pm:

Roses are red, Violets are blue, I'm schizophrenic, And so am I!!! ;D I kill myself, really I do!!!!! Joe

  ;D ;D ;D ;D ;D
I added two more after reading it again.

         Potter

Maybe he's been listening to an oldies station.  Wasn't it the Chi-Lites who sang "A Letter to Myself"?

Jerry

Edit to add:  If I take all that vitamin D plus walk three hours in the mid-day sun in Jan in Chicago, won't I overdose on Vitamin D??? :D

Not in January. The azimuth isn't steep enough.. ;D

wrote on Oct 27^th, 2010 at 4:27pm:

Hi I just got a mail from Niels. He has been CH free for almost 2 years after taking 200 µg vitamin D3 and 500 mg magnesium chloride pr. day. Before starting supplementing he had about 140-200 CH days pr. year since 1990.  :)

Dude, we know it's you.  Just in case the previous replies were too subtle.    ::)

Best,

George

Which Seinfeld episode was it where the guy at the gym always talked in the third person.....Joe thinks this is a bad idea, Joe thinks he needs more sun, Joe thinks he's going to stop taking dangerous meds and over dose on milk! ;)

Joe

wrote on Oct 28^th, 2010 at 8:03am:

Hi Niels feel sorry for you, that you have to take dangeous medicine, when there is a naturaly way to get rit of the pain.  :'( Quote: If I take all that vitamin D plus walk three hours in the mid-day sun in Jan in Chicago, won't I overdose on Vitamin D? The answer is very simple. NO

George says he thinks it's worthwhile to save Neils's responses as quotes for posterity.  Neils has a tendency to make 'em go "poof" after the fact. Or at least Neils did when he was "Neils", "D-3", and "Haug".

Best,

George and me. 

Quote:

Niels feel sorry for you

Thats ok....Jimi and I feel sorry for you too. :D

Sounds like a schitzophrenic convention going on here.  (Not that I can spell schitzophrenic, but me, myself and I are one)

Jerry

Looks like Niels deleted his profile and all his posts again.  He does that. 

Glad we saved some of his posts by quoting them.  History can be cool.   8-)

Best,

George   

Jerry, I hope you got your question answered?  Sorry for the craziness.

:)mel