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Cluster Headache Help and Support >> Medications,  Treatments,  Therapies >> i cant believe im gonna do this!
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Message started by chrisw on Nov 22nd, 2011 at 9:49pm

Title: i cant believe im gonna do this!
Post by chrisw on Nov 22nd, 2011 at 9:49pm
Im going to take a dose of LSD prob tomorrow night.  Tried shrooms, i think my antiseizure meds blocked the effects.  Im starting a cycle, and my son who is in college knew someone to get the acid from.  This is crazy,  im a middle aged woman. ! Im gonna try not to be scared so it doesnt send me into a bad trip.  any advice would be greatly appreciated, because I am just guessing on what to do. :o :o :o

Title: Re: i cant believe im gonna do this!
Post by Brew on Nov 22nd, 2011 at 9:58pm
If the anti-seizure meds blocked the fungus, it will block other busting meds as well. You likely need to be off the anti-seizure stuff for a minimum of 5 days before dosing.

Title: Re: i cant believe im gonna do this!
Post by chrisw on Nov 23rd, 2011 at 7:25am
great, (sarcasm),  oh well i guess i have nothing to fear then.  Im going to try it anyway,  I cant go off my meds.  The longest I can risk it is maybe 24 hrs.  The fastest way to bring on a horrible ha, is to have a bad seizure..  Maybe Ill skip 24 hrs and then try in the morning of the next day.

thanks for the advice.  I just dont know if i should even do it now, because I woke up yesterday with a mild HA, and I thought oh boy here we go, and then today,,, nothing.    I know youre supposed to try and dose at the very beginning of a cycle so i guess this is the best time if i get another ha.  scared
:-/ :-/

Title: Re: i cant believe im gonna do this!
Post by Brew on Nov 23rd, 2011 at 7:42am
You should also know that you'll want to be prepared to hit the busting meds a number of times in a row, each dose separated by 5-7 days (funny how busting meds will block themselves from effectiveness if not spaced out over time properly).

Here's some literature from the clusterbusters site about drug interacations:


Quote:
PLAYING WELL TOGETHER


Every doctor, every pharmacist, will warn about drug interactions...some chemicals simply do not play well with others in the body. Sometimes, one drug will block the actions of another. Sometimes, one drug will strengthen or change the actions of another, or the two together will cause something else entirely to happen.

The bad news for clusterheads: many medications commonly used to treat clusters will block the effectiveness of tryptamines. In fact, when the clusterbuster treatment doesn’t work, most of the time it is because these drugs are interfering.

There are other drugs and substances that make the tryptamines work too well...that is, they enhance the psychedelic side effects of tryptamines, and make for some unwanted surprises.

Based on the reports of clusterheads and expectations based on research and theory, Clusterbusters made a list of drugs likely to interfere with the treatment. There are other drugs we are not sure will interact with tryptamines, and drugs that might enhance the psychoactive effect of tryptamines. And of course there are drugs and treatment that do play well with cluster-busting tryptamines.

Experience has shown the clusterbuster treatment works best when drugs that interfere are avoided for long enough to be cleared from the body. We call this period “detox,” short for “detoxification,” though technically, this is not the proper term. Many clusterheads use some of these drugs for other conditions, and should talk with their doctors before stopping or changing any medications; some cluster medications must be withdrawn from slowly with a prescribed schedule so, again, see your doctor first.

Dropping cluster meds can be difficult while the attacks keep coming, but there are ways to help you survive during detox. See COPING - BUSTER-FRIENDLY TREATMENTS: START PRINTPAGEMultimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to Login or RegisterEND PRINTPAGE
and OXYGEN INBFORMATION:
START PRINTPAGEMultimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to Login or RegisterEND PRINTPAGE

SURE BLOCKERS

Triptans

Perhaps the most common culprits for ClusterBuster failure are the triptans, since they unfortunately are the most popular abortive treatments for cluster attacks. Sumatriptan (Imitrex) can stop an attack quickly, and it’s possible it foils the clusterbuster treatment more often than any other blocker. Other triptans are used less often, and there are fewer experiences, but for the sake of caution, these should also be avoided.

Sumatriptan (Imitrex®)
Zolmatriptan (Zomig®)
Rizatriptan (Maxalt®)
Naratriptan (Amerge®)
Frovatriptan (Frova®)
Almotriptan (Axert®)
Eletriptan (Relpax®)

Steroids

Steroids, the corticosteroids Prednisone and Prednisolone particularly, can be very effective at completely stopping cluster attacks while they are being used. They are also very effective at causing some nasty side effects, and most doctors prescribe them only for short periods in decreasing dosages.

There are many reports that prednisone will block the clusterbuster treatment.

Verapamil and other calcium channel blockers

Verapamil is a blood-pressure drug often prescribed for the long-term, preventive treatment of clusters. Most reports seem to indicate verapamil and other calcium channel blockers will interfere with the clusterbuster treatment, though a few say they successfully used tryptamines while on verapamil, and some reports seem to indicate that it impeded but didn’t completely block the treatment. Verapamil is known by the brand names Isoptin, Verelan, Verelan PM, Calan, Bosoptin and Covera-HS.

Anti-convulsants

Topamax (topiramate) is another of those drugs developed for some other disease that clusterheads have found useful. Many find its side effects objectionable. There are indications it will block the effectiveness of tryptamines, as will other anti-seizure medications such as Depakote and Tegretol.

Opiates

Opiates usually have little to no effect on clusters for most, but a few say the stuff works for them, and it is too-often prescribed by doctors in desperation or under the faulty assumption that such powerful pain killers must automatically work for painful “headaches.” There are many tales of emergency room doctors who are surprised and aghast when a shot of morphine has no effect on a cluster attack.

Other drawbacks - the infamous addiction potential, while sometimes overstated, is real. It results in such medications becoming a target for theft. In any case the opiate and opioid pain killers seem to interfere with the cluster treatment. There are many in use; here is an incomplete list:

•Opium
•Morphine
•Heroin
•Codeine
•Demerol (pethidine)
•Percoset (oxycodone)
•Oxycodone
•Oxycontin (oxycodone)
•Hydrocodone
•Fentanyl
•Buprenorphine
•Methadone
•Tramadol
•Vicodin (hydrocodone)
•Dilaudid (hydromorphone)
•Actiq (fentanyl)
•Duragesic (fentanyl)
•Suboxone (buprenorphine)
•Ultram (tramadol)
•Ultracet (tramadol)

Ergotamines

Including but not limited to:
     •Dihydroergotamine (DHE) (nasal sprays [migranal] and injections)
     •Sansert
     •Cafergot
     •Ergomar

The molecules of these substances are very similar in shape to the tryptamines. This means they fill the same neuroreceptors as tryptamines, and interfere with the clusterbuster method. They can have some very serious side effects as well. They are powerful vasoconstrictors, and can cause bad circulation problems, particularly in the fingers and toes.

SSRIs

SSRIs, or selective serotonin re-uptake inhibitors, widely used to treat mood and other psychological disorders may be blockers, as they are involved with serotonin. The SSRIs include Prozac, Celexa, Lexapro, Paxil and Zoloft.
Other similar serotonin-affecting drugs include Effexor, Pristiq and Cymbalta. Drugs known as tricyclics, including Elevil and Tofranil. may also interfere with tryptamine treatment.


ENHANCERS

Lithium

People taking lithium, whether it is for preventing cluster headaches or for some other reason (it is often prescribed for people with bipolar affective disorder - see below for more on bipolar disorder). Anecdotal reports suggest that lithium can greatly potentiate the effects of LSD or mushrooms, and that it can produce very unpleasant feelings. An examination of a number of reports suggested that lithium can either increase or decrease effects.

The combination of lithium and tryptamines may even produce episodes that seem like, and that perhaps are, epileptic seizures. If people are taking lithium for treating cluster headaches and it is not working, they may want to talk with their doctor about not taking it any more before trying mushrooms or LSD. If people are taking lithium for bipolar affective disorder, they probably should continue taking lithium, and they should avoid taking tryptamines for cluster headaches.

MAOIs

Monoamine oxidase inhibitors (MAOIs) such as Nardil or Parnate are prescribed for depression and sometimes other conditions. They can block the action of enzymes that can break down some tryptamines, and as such may act to intensify the action of a given dose of tryptamine, especially when first taking tryptamines. However, after continued use (as perhaps after a month or more), MAOIs will tend to reduce the psychedelic effects of mushrooms and LSD. It is not known if long term use of MAOIs will interfere with tryptamine treatment of cluster headache, but it is possible.


NON-BLOCKERS

There are substances which will probably not interfere with the actions of psilocybin:
     •      antibiotics
     •      NSAIDs (non-steroidal anti-inflammatory drugs) such as Tylenol                 (acetaminophen), aspirin,      ibuprofen, Vioxx (rofecoxib), etc.
     •      antacids and anti-ulcer medications
     •      asthma medications
     •      insulin
     •      caffeine
     •      caffeine/taurine energy drinks
     •      Tylenol
     •      aspirin
     •      B-Complex and multi vitamins
     •      Diovan (blood pressure)
     •      protonix (for acid reflux)
     •      Indomethacin
     •      meclizine and dimenhydramine (The antinausea agents)      
     •      Lipitor
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Title: Re: i cant believe im gonna do this!
Post by chrisw on Nov 23rd, 2011 at 6:15pm
do you think i should cut that little bit of paper in half? so that I can get at least two doses out of it.  I dont think i can get any more for a while.  I guess this is probably a waste of time.

I take trileptal and zonagran for seizures.

oh well :-?

Title: Re: i cant believe im gonna do this!
Post by bejeeber on Nov 24th, 2011 at 1:54am
This subject is the main focus over at the clusterbusters.com message board, and there are folks there who are eager to assist with it, so I think it would be a good idea to also check in over there with your questions. START PRINTPAGEMultimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to Login or RegisterEND PRINTPAGE

Lots and lots of middle aged folks are "busting" (including myself!) so no need to feel odd or out of place at all.

Relaxation herbs like valerian, skullcap, hops etc. are known to help with avoiding a bad trip.




Title: Re: i cant believe im gonna do this!
Post by Brew on Nov 24th, 2011 at 9:36am
If you could order yourself a bag of Rivea Corymbosa seeds, you could do follow-up busts. Or start out with the RC and save the paper for later. You have lots of options. Do as bejeeber suggests - go to START PRINTPAGEMultimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to Login or RegisterEND PRINTPAGE for ideas and suggestions.

Title: Re: i cant believe im gonna do this!
Post by chrisw on Nov 25th, 2011 at 12:04pm
well,  i just jumped in and took it last night. I almost chickened out, but then I started feeling some mild headpain which is what always happens about a week in advance of the startup of the cluster.  I told myself, that if you can get through yrs of CH, you shouldnt be afraid of a little bit of hallucinations. It didnt have too much of an effect on me.  I waited until everyone was asleep and put it under my tongue, and left it there.  I did it when i was very tired hoping to fall right asleep and sleep through the effects.
     A very strange dream woke me up about 45 min later, and the only real effect was that it kept me awake all night long.  I kept seeing some shadows and movement in the corner of my eyes and when I would look nothing was there.  Not too bad,  but I dont think I got the full effect.  Im pretty sure it was a waste of time, but I figured that I should go ahead and try it before my window of perfect timing went away.
     I am going to try and get something else in about a week, like some shrooms or another hit, and try again, unless my clusters kick in and then I will know it didnt help at all.

thanks for taking the time to give me some much needed advice everyone.  I at least feel like Ive tried to help myself in a less invasive way. :-*

Title: Re: i cant believe im gonna do this!
Post by vietvet2tours on Nov 25th, 2011 at 12:18pm

chrisw wrote on Nov 25th, 2011 at 12:04pm:
well,  i just jumped in and took it last night. I almost chickened out, but then I started feeling some mild headpain which is what always happens about a week in advance of the startup of the cluster.  I told myself, that if you can get through yrs of CH, you shouldnt be afraid of a little bit of hallucinations. It didnt have too much of an effect on me.  I waited until everyone was asleep and put it under my tongue, and left it there.  I did it when i was very tired hoping to fall right asleep and sleep through the effects.
     A very strange dream woke me up about 45 min later, and the only real effect was that it kept me awake all night long.  I kept seeing some shadows and movement in the corner of my eyes and when I would look nothing was there.  Not too bad,  but I dont think I got the full effect.  Im pretty sure it was a waste of time, but I figured that I should go ahead and try it before my window of perfect timing went away.
     I am going to try and get something else in about a week, like some shrooms or another hit, and try again, unless my clusters kick in and then I will know it didnt help at all.

thanks for taking the time to give me some much needed advice everyone.  I at least feel like Ive tried to help myself in a less invasive way. :-*

It worked perfectly.  Yer not supposed to turn into a Furry Freak Brother.

        Potter

Title: Re: i cant believe im gonna do this!
Post by chrisw on Nov 25th, 2011 at 6:04pm
No pain today!!!  Dont know if the lsd is why, but other than being tired, i feel great!!!!!!

anyone who is afraid to jump in and give it a try,  go for it,  its not as scary as a cluster headache!!!!! :-*

Title: Re: i cant believe im gonna do this!
Post by bejeeber on Nov 25th, 2011 at 6:44pm
Encouraging....really hoping here that the pain free status continues!

I too tend to feel generally good after a bust (but not necessarily during a bust).

If you're not able to find other busting materials in a week, please keep in mind that the RC seeds Brew mentioned can be overnighted to you.  8-)

Title: Re: i cant believe im gonna do this!
Post by chrisw on Nov 30th, 2011 at 2:35pm
Im sorry to say it was a waste of time and energy.  The beast came back with a vengence for the past couple of nights.  Oh well, now I know its not my thing.  Back to the doctor.  Boo hoo. :'(

Title: Re: i cant believe im gonna do this!
Post by Brew on Nov 30th, 2011 at 3:05pm
Seems you're giving up pretty quickly.

Busting is NOT a one-time cure-all. Sometimes - like in my case - I had to stay after it for months, every 5-7 days. But now I do a maintenance dose every 6 months or so, and I'm good to go with nothing but an occasional shadow. And that's been almost two years ago now. You might want to read in more depth about the entire busting experience.

Or, you can go back to the doctor. Boo hoo.

Title: Re: i cant believe im gonna do this!
Post by chrisw on Dec 1st, 2011 at 7:34am
Thanks Brew,  but with my seizures, I would have needed to see a little more relief to keep with it.  Its dangerous for me to skip my meds like that, and I dont think i got much of a reaction to the LSD.  If that was it,  I doubt the hippies of the past would have wasted their time.  Thank you so much for your support though!!!!!! :-* :-* You really are a great person for rallying on others who are wading through those uncharted waters :-* :-*

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