J Neurol. 2013 Jul 14. [Epub ahead of print]

Cluster headache and oxygen: is it possible to predict which patients will be relieved? A prospective cross-sectional correlation study.

Haane DY, de Ceuster LM, Geerlings RP, Dirkx TH, Koehler PJ.
Source
Department of Neurology, Atrium Medical Centre Parkstad, PO Box 4446, 6401 CX, Heerlen, The Netherlands

Abstract

Response to 100 % oxygen as acute treatment for cluster headache is relative low considering certain subgroups or predictors. The primary purpose of the present study was to find prospectively which factors differ between responders and non-responders to oxygen therapy. The second goal was to find whether any of these differences would clarify the mechanism of pain reduction by oxygen and cluster headache pathophysiology. Patients diagnosed with cluster headache according to the ICHD-II criteria, who started on oxygen therapy (n = 193), were recruited from 51 outpatient clinics and via patient websites in The Netherlands. Patients had to return two questionnaires around the start of oxygen therapy (n = 120). Eventually, 94 patients were included. Clear non- plus moderate responders had ever used pizotifen more often (p = 0.03). Clear non-responders more often had photophobia or phonophobia during cluster headache attacks (p = 0.047) and more often had used triptans in the same active phase as the phase in which they had used oxygen for the first time (p = 0.02). Using correction for multiple testing, we could only confirm a statistically significant difference in triptan use. We were unable to locate the level of action of oxygen in the thalamus and cortex or confirm the sites of its action presently known, solely based on current knowledge of photophobia circuits. However, we conclude that particularly the higher frequency of photophobia or phonophobia in clear non-responders deserves further study to understand the mechanism of pain reduction by oxygen and cluster headache pathophysiology.

I will only say that I have personally witnessed incredibly high success rates with O2 when applied as need for each individual. (Some need much higher flow rates than others)

On the flip side of that, I have seen a lot of anecdotal evidence of O2 failing to provide relief in "Cluster like headaches." 

There was a time when the general consensus here was that if O2 didn't help, you might not have the same type Cluster Headache that the rest of us do. Some even considered oxygen therapy to be sort of an "acid test" for CH's.

Marc

Hi Mark,
I can't rearly agree/disagree on this one. Around 30yrs ago
my neuro suggested i try 02, but it was'nt an option for me
as i worked away from home a lot, so i stuck with Migral,
which i had learned over time the exact time to take them
to knock the [smiley=evil.gif] on the head. When they were
no longer available i went onto Imigran.I'm now on the D3
Regime and pain free.

Hoppy.