You've probably heard of it.  Indomethacin is usually prescribed for hemi-crania continua (one of the few conditions that can seem like cluster headache but is not) although there is at least one case report of a CH sufferer finding relief only from Indomethacin. 

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In my opinion this is a majorly inferior drug with way too many side effects that you should not be on unless absolutely necessary (as in nothing else works). That being said, if I had no other options I would probably take it.

The reason I am posting about it is for those people that get stuck on it.   I came across this study that claims that something in the Amazonian Guarana seed protects against Indomethacin induced gastric lesions, which is the biggest concern with this drug.

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Guarana has a good bit of caffeine in it so it may be helpful on it's own for clusters...If Indomethacin was the only thing that worked for me I would make sure to take Guarana with it. 

-Ricardo

CPH is much like CH except the attacks are shorter lived.  Indo is 100% effective against CPH.  I would suggest everyone start on Indo to determine if they have CPH or CH.  If it doesn't stop the attacks, drop it and move to more conventional CH treatments.

When my neuro thought I had PHC i was prescribed indomethicin, but also had omeprosole to protect my stomach.

I take it only with meals and that stops much of the tummy troubles.

It's been decades since I've seen Indo being used for Cluster, it having been replaced by the meds which fill our messages now.

I had to use it for 25-years to conrol Ankylosing Spondylitis for which Indo was first choice. It's dose dependent re. side effects, ulcers being a major concern. But even with long term use, supportive meds could largely reduce side effects. Having said this, I had to get off it after this long use, fortunately at the point where I was aging out of the AS anyway.

I have used it for short periods 20-yrs on when my knees was wearing out and needed to be replaced. It was then, as the earlier use, a wonderully effective drug and, not withstanding the much earlier side effects, I was comfortable using it again because of the rapid elimination of the bone pain.

Bottom line, as with many meds, to be used with knowledge and care but not refused outright.

Yeah, in my personal experience with my neurologist and indomethacin
I agree with Bob P.