One of the very few scientific findings on CH is the famous "more gray matter" in the hypothalamus.  Se fx START PRINTPAGEMultimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to or END PRINTPAGE

Many has interpreted this as some kind of defect. I've never been convinced.

Now it seems more gray matter in another region of the brain is linked to the feeling of happiness.  START PRINTPAGEMultimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to or END PRINTPAGE.

Perhaps that is a defect too.

Some additional food for thought when it comes to the brain, vitamin D3 and its capacity to prevent CH...

START PRINTPAGEMultimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to or END PRINTPAGE

Abstract
"Despite a growing body of evidence that Vitamin D is involved in mammalian brain functioning, there has been a lack of direct evidence about its role in the human brain. This paper reports, for the first time, the distribution of the 1,25-dihydroxyvitamin D
3 receptor (VDR), and 1a-hydroxylase (1a-OHase), the enzyme responsible for the formation of the active vitamin in the human brain.

The receptor and the enzyme were found in both neurons and glial cells in a regional and layer-specific pattern. The VDR was restricted to the nucleus whilst 1a-OHase was distributed throughout the cytoplasm. The distribution of the VDR in human brain was strikingly similar to that reported in rodents.

Many regions contained equivalent amounts of both the VDR and 1a-OHase, however the macrocellular cells within the nucleus basalis of Meynert (NBM) and the Purkinje cells in the cerebellum expressed 1a-OHase in the absence of VDR. The strongest immunohistochemical staining for both the receptor and enzyme was in the hypothalamus and in the large (presumably dopaminergic) neurons within the substantia nigra.

The observed distribution of the VDR is consistent with the proposal that Vitamin D operates in a similar fashion to the known neurosteroids. The widespread distribution of 1a-OHase and the VDR suggests that Vitamin D may have autocrine/paracrine properties in the human brain."

I stopped reading when I got to the bit that says "seems to only effect men".