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Cluster Headache Help and Support >> Medications, Treatments, Therapies >> Call Out; Research on BP spikes in realtion to CH http://www.clusterheadaches.com/cgi-bin/yabb2/YaBB.pl?num=1424953619 Message started by lancashire Lad on Feb 26th, 2015 at 7:26am |
Title: Call Out; Research on BP spikes in realtion to CH Post by lancashire Lad on Feb 26th, 2015 at 7:26am
Does anyone know of specific research in blood pressure spikes with regards CH or any Primary HA.
Also what is current technology status on Real Time Continuous Blood Pressure Monitoring. Reason, I am interested to research possible links of (commonality of) "Tringgers" in creating a ramp in blood pressure. And also any research on Hypertension remedies that not only reduce BP but level out spikes. It appears that many of the things that give relief to CH also have a property of reducing BP; Drugs (incl vit D), Oxygen (reducing blood flow), nerve stimulation, relaxation/meditation etc I am convinced the relationship of internal BP (general and cranial) and atmospheric has an influence, so it may not be an internal trigger; food, drug,alcohol, anxiety/mood change etc but also if there is a rapid enough gradient change in lowering of atmospheric pressure (AP) then the resulting ratio between BP/AP would mimic an increase in BP. I am particularly interested in what this gradient / ramp (increase in BP / Time) might be (if it exists as a function of CH); so relative BP (BP/AP) increase over "x" time is trigger but over "y" time not? And it is specifically the ramp that I am interested in; in the population of normally; low, normal and high BP's not just hypertensive individuals. Any pointers to existing research would be much appreciated. |
Title: Re: Call Out; Research on BP spikes in realtion to CH Post by lancashire Lad on Feb 27th, 2015 at 6:22am
It appears there is a known condition of excessive variation in blood pressure that can lead to strokes. A drug group that can even out the spikes are Calcium Channel Blockers (CCB), one such blocker is Verapamil.
The theory goes like this; there is an underlying condition eg a trapped, squeezed, nipped, squashed nerve that is sending signals to the processing bits of the brain including the hypothalamus. The brain becomes accustomed to the signals but notes that something isn't right. Pain is the brains way of alerting us to danger and protecting an injured area until it has had chance to heal. If the brain thinks a stroke is imminent it may decide to stop us dead in our tracks with a CH or other Primary HA before ... well we are dead in our tracks. The precurser to many strokes is a Blood Pressure spike that can occur in anyone (with low, normal or high BP). Lowering the BP will assist the brain in accepting the danger is over; oxygen, drugs, relaxation etc. But to help prevent the brain getting panicky the spikes have to be evened out with CCB eg Verapamil or perhaps D3. It would be good is some neurologists and pain specialists could get together and test the theory in a trial but the endpoint (a "cure") would be to identify the underlying problem (impacted nerve), evening out the spikes in BP and persuading the brain not to be panicked. |
Title: Re: Call Out; Research on BP spikes in realtion to CH Post by Mike NZ on Feb 27th, 2015 at 4:01pm
Before I was diagnosed with CH I was admitted to hospital for about a week for tests galore, including MRI / CT scans and every other test they seemed to think of.
One of the tests included seeing if my BP spiked when the headache pain started. I remember one when the CH started and they were doing the tests, being told I'd to remain totally still (not easy with a CH). They also did an ECG at the time too. I don't remember the actual results, but they didn't continue with this testing once they'd got a "good" set of data from a CH. This memory isn't perfect as it was almost 5 years ago, I was still suffering quite strongly from the effects of a concussion which kick started my CH and I was being given a lot of codeine to try to limit the pain that I was going through. But I won't forget having to remain as still as possible when all I wanted to do was the CH "dance". |
Title: Re: Call Out; Research on BP spikes in realtion to CH Post by jon019 on Feb 27th, 2015 at 9:48pm
Hi LL,
Out of curiosity, or some other compunction (clusterhead compulsive action?), I used to occasionally self test BP during (yikes, that was hard...see Mike's comments above) and after a ch hit. It was always remarkably and scarily HIGH...and I stopped as pointless anyway....as there was nothing I could do about it and I was already on 480-1020 mg/dy verapamil.... I have always assumed pain...adrenaline...panic..anger...the dance...etc were all causing high BP... never considered the alternative that high BP was a trigger...interesting. The only way I can see to test would be a constant BP monitoring during active CH cycle... with careful correlation to timing of hits. Given the limited research funding for anything ch related. small number of clusterheads, and lack of money making opportunites off of us...I'm not holding my breath...but it would be interesting. Best Jon |
Title: Re: Call Out; Research on BP spikes in realtion to CH Post by Peter510 on Feb 28th, 2015 at 5:58am
Hi there,
Some 3/4 years ago, while in hospital for tests ( yet more tests) I was on a 24 hour BP monitor. I was being hit hard every couple of hours at the time and sucking oxygen like my life depended on it. The BP result came back with no change whatsoever during the entire period. I have to say the Doctors were surprised. My BP, which I check regularly myself and is "officially" checked every 4 weeks, as I donate Platelets, is always 120/80. Maybe I'm just lucky in this regard, but a CH hit doesn't seem to make any difference to my BP. Just a comment, for what it's worth. Keep well everyone. Peter. |
Title: Re: Call Out; Research on BP spikes in realtion to CH Post by lancashire Lad on Feb 28th, 2015 at 10:40am
Jon & Peter
The theory, for what it's worth, is that the spike occurs before an attack. Hence my interest in Real Time Continuous BP monitoring, the non invasive, current stuff, appears to be algorithm based, so BP this at this time vs BP at another means avg must have been somewhere in between the two (false conclusion) No ones BP remains constant. But the theory here is that a ramp in BP that the brain doesn't like results in CH and other primary HA's. That ramp may be over hours, perhaps minutes but if it over seconds then current (non invasive) motitoring is likely not to catch it. And as I understand the "in-line" monitoring (invasive) is flow rate, so not the same as BP. Elasticity in the blood carrying vessels is supported by K2 (long molecule) and D (in various forms) so increased blood flow can have a dampened effect on BP if the environment is right, if not BP will rise and blood carrying vessels expand. If this presses on one of the nerves that can create problems then there is a good chance it will. |
Title: Re: Call Out; Research on BP spikes in realtion to CH Post by lancashire Lad on Feb 28th, 2015 at 10:47am
ps after the first hit anxiety will kick in to create all the other hits until the brain realises its not dead yet, panic over!
Hence success of placebos (increased effectiveness over norm in primary headache) and CBT and relaxation therapies etc. If the brain stops thinking a stroke is about to hit then it starts to calm down. Until the next spike. |
Title: Re: Call Out; Research on BP spikes in realtion to CH Post by Peter510 on Feb 28th, 2015 at 11:29am
Hmmmmmm !!!
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Title: Re: Call Out; Research on BP spikes in realtion to CH Post by Bob Johnson on Feb 28th, 2015 at 2:00pm
In the 40+ years that I've been reading about Cluster I don't recall any causal linkage with BP.
A short term elevation as a part of a stress reaction, either to an attack or in anticipation of an attack, is consistent to the literature. |
Title: Re: Call Out; Research on BP spikes in realtion to CH Post by lancashire Lad on Feb 28th, 2015 at 3:51pm
BP spike not a "cause", but part of the cause. A/The final trigger, I suggest.
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Title: Re: Call Out; Research on BP spikes in realtion to CH Post by lancashire Lad on Mar 1st, 2015 at 6:28pm
The "remarkable" aspect is 115 obserations on hypertension in non hypertensive patients. But yes a proper trial needs to be done.
Coffee, chocolate, alcohol and sex cause spikes in BP (amongst other things) they also trigger Primary headaches. |
Title: Re: Call Out; Research on BP spikes in realtion to CH Post by Mike NZ on Mar 1st, 2015 at 6:51pm lancashire Lad wrote on Mar 1st, 2015 at 6:28pm:
The trial will also need to include a control group of non-CH / migraine patients too to really get an understanding of what is "normal". Now the $64,000 question is who will fund such a study? |
Title: Re: Call Out; Research on BP spikes in realtion to CH Post by lancashire Lad on Mar 1st, 2015 at 7:15pm
"who will fund such a study"
If there's no money in it, the pharmas won't but there is no need for further trials; The raw data exists, someone might want to pick it up for a phD thesis. Things that cause BP spikes cause Primary HA's (incl CH). Things that stop spikes stop Primary HA's (incl CH). Now where's me dosh? (or failing that my phD) |
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