Hi,

Here is a experience from 2003
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Code:

clusterheadaches.com/cgi-bin/yabb/YaBB.cgi?board=medsarchive2003;action=display;num=1044880959

Quote:

I had personal success gradually terminating a cluster headache and almost entirely preventing chronic suffering for two months with 475mg of Dextromethorphan Hydrobromide. I believe that there is much more to preventing cluster headaches than a selective serotonin antagonist I believe there is a chemical correlation between the psychoactive effects of DXM and psilocilin, despite the mechanisms employed for reaching those effects

DXM is a Uncompetitive antagonist of the NMDA receptor via the MK-801/PCP site
DXM Like Ketmaine induces a trance soothing euphoric like state while providing pain relief, sedation & other effects.

Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump.


Antagonism of the NMDA receptor is thought to be responsible for the anesthetic, amnesic, dissociative, and effects of ketamine & dxm


1Dextromethorphan Analgesia in a Human Experimental Model of Hyperalgesia
2A Systematic Review of NMDA Receptor Antagonists for Treatment of Neuropathic Pain in Clinical Practice
3Dextromethorphan and Memantine After Ketamine Analgesia: A Randomized Control Trial
4Search Query


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DXM Can be bought OTC all around the world except for France & Sweden.... In USA it is even sold on Amazon & Walmart
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When buying the medicine, make sure the only ingredient is Dextromethorphan.
Depending on the brand, you can it cheap as chips from eBay & Amazomn

Some quick reports of online DXM Reports: Cough Medicine? More Like Soul Medicine ;Analgesic Application of Smaller Dose;Transcending the Ego: A Journey through Love;
No Buzz, No Hangover, Just a Perfect World;Enough to Skip One Dose of My Medication

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Dextromethorphan and Memantine After Ketamine Analgesia: A Randomized Control Trial

Purpose: Intravenous ketamine is often prescribed in severe neuropathic pain. Oral N-methyl-D-aspartate receptor (NMDAR) antagonists might prolong pain relief, reducing the frequency of ketamine infusions and hospital admissions. This clinical trial aimed at assessing whether oral dextromethorphan or memantine might prolong pain relief after intravenous ketamine.

Patients and methods: A multicenter randomized controlled clinical trial included 60 patients after ketamine infusion for refractory neuropathic pain. Dextromethorphan (90 mg/day), memantine (20 mg/day) or placebo was given for 12 weeks (n=20 each) after ketamine infusion. The primary endpoint was pain intensity at one month. Secondary endpoints included pain, sleep, anxiety, depression, cognitive function and quality of life evaluations up to 12 weeks.

Results: At 1 month, dextromethorphan maintained ketamine pain relief (Numeric Pain Scale: 4.01±1.87 to 4.05±2.61, p=0.53) and diminished pain paroxysms (p=0.03) while pain intensity increased significantly with memantine and placebo (p=0.04). At 3 months, pain remained lower than at inclusion (p=0.001) and was not significantly different in the three groups. Significant benefits were observed on cognitive-affective domains and quality of life for dextromethorphan and memantine (p<0.05).

Conclusions: Oral dextromethorphan given after ketamine infusion extends pain relief during one month and could help patients to better cope with pain. Future studies should include larger populations stratified on pharmacogenetics screening. Optimization of an oral drug that could extend ketamine antihyperalgesia, with fewer hospital admissions, remains a prime challenge in refractory neuropathic pain.

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Figure 4 Effect of dextromethorphan, memantine and placebo on Brief Pain Inventory (BPI) score and Short-Form 36 (SF-36) parameters assessed after ketamine infusion (postK), Month 1, 2 and 3 (M1, M2, M3). Notes: (A) Scores of “Worst pain” and “Walking inability” BPI sub-scores assessed at M1 were significantly decreased in the dextromethorphan group compared to memantine and placebo groups. (B) Scores of “General health” and “Vitality” SF-36 sub scores were significantly higher in the memantine group at M2 and M3 respectively compared to dextromethorphan and placebo groups. (C) Percentage change (%) represents the difference between postK and M3 of “Role emotional” SF-36 sub score. At M3 “Role emotional” sub score increases significantly in memantine group compared to dextromethorphan and placebo groups.

Come on anyone try DXM?