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atsea CH.com Newbie Offline I Love CH.com! Posts: 21	nimodepine? Dec 16^th, 2009 at 10:20pm anyone ever used nimodepine as an abortive? how about trexamet? i know its just a imitrex derivitive, but, i hear first hand it is more effective and faster than the imitrex subQ. starting verapamil as a prophylactic. 360 mg/day as well.
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deltadarlin

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Re: nimodepine?
Reply #1 - Dec 17^th, 2009 at 8:00am

I've never heard of using a calcium channel blocker as an abortive. Most CCBs are used as preventatives, not abortives.

As to treximet. Don't know about ch, but I was using treximet for migraines, long before it was even developed (I'd take Imitrex and an aleve at the same time). Didn't work any better. Treximet is just a fancy name for a combo of aleve and Imitrex (moer expensive because there is no generic equivalent).

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atsea CH.com Newbie Offline I Love CH.com! Posts: 21	Re: nimodepine? Reply #2 - Dec 17^th, 2009 at 8:42am its apparently a very swift and powerful does of CCB. you bite the liquid filled capsule with your teeth suck out the goodness and swallow it. its suppoed to stop an attack dead in its tracks
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deltadarlin CH.com Alumnus Offline I love YaBB 1G - SP1! Posts: 3823 Downsville LA Gender:	Re: nimodepine? Reply #3 - Dec 17^th, 2009 at 8:45am Post this on the medications board, you'll get more info there.
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Marc Ex Member Gender:	Re: nimodepine? Reply #4 - Dec 17^th, 2009 at 8:54am atsea wrote on Dec 17^th, 2009 at 8:42am: its apparently a very swift and powerful does of CCB. you bite the liquid filled capsule with your teeth suck out the goodness and swallow it. its suppoed to stop an attack dead in its tracks What is your source of info on this? Marc
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Redd

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Re: nimodepine?
Reply #5 - Dec 17^th, 2009 at 9:37am

Suitable vasodilator agents for use herein include nimodepine, pinacidii, cyclandelate, isoxsuprine, chloroprumazine, halo peridol, Rec 15/2739

Not an abstract regarding CH. but I don't think it's a good idea to apply a vasodilator as an abortive of a CH attack.

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Marc Ex Member Gender:	Re: nimodepine? Reply #6 - Dec 17^th, 2009 at 9:55am In some listings, Verapamil is also listed as a vasodilator - as we know, it also a CCB - which are not true dilators. They function by "relaxing" the constricting/dilating action of smooth muscle tissue. Marc
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atsea CH.com Newbie Offline I Love CH.com! Posts: 21	Re: nimodepine? Reply #7 - Dec 17^th, 2009 at 11:59am the nimodepine treatment was cited in a HEADACHE JOURNAL article written by a renowned MAYO clinic neurologist.
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Brew CH.com Sponsor CH.com Alumnus Offline Posts: 14163	Re: nimodepine? Reply #8 - Dec 17^th, 2009 at 12:06pm atsea wrote on Dec 17^th, 2009 at 11:59am: the nimodepine treatment was cited in a HEADACHE JOURNAL article written by a renowned MAYO clinic neurologist. Which issue, what author?
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atsea CH.com Newbie Offline I Love CH.com! Posts: 21	Re: nimodepine? Reply #9 - Dec 17^th, 2009 at 9:32pm damn. i'll have to find the issue again. i though i bookmarked it. it was authored my robert ford?
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Redd

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Re: nimodepine?
Reply #10 - Dec 17^th, 2009 at 10:18pm

Marc wrote on Dec 17^th, 2009 at 9:55am:

In some listings, Verapamil is also listed as a vasodilator - as we know, it also a CCB - which are not true dilators. They function by "relaxing" the constricting/dilating action of smooth muscle tissue.

Marc

True, but Verap. isn't used as an abortive agent either.

I guess I just cringe at the notion of a vasodilator as a Ch abortive agent. Sort of like prescribing nitroglycerin as an abortive.......

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Bob P CH.com Hall of Famer Offline Shut up Bob! Posts: 4573 Clio,California Gender:	Re: nimodepine? Reply #11 - Dec 18^th, 2009 at 7:37am Multimedia File Viewing and Clickable Links are available for Registered Members only!! You need to or
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Marc

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Re: nimodepine?
Reply #12 - Dec 18^th, 2009 at 9:38am

Redd wrote on Dec 17^th, 2009 at 10:18pm:

Marc wrote on Dec 17^th, 2009 at 9:55am:

In some listings, Verapamil is also listed as a vasodilator - as we know, it also a CCB - which are not true dilators. They function by "relaxing" the constricting/dilating action of smooth muscle tissue.

Marc

True, but Verap. isn't used as an abortive agent either.

I guess I just cringe at the notion of a vasodilator as a Ch abortive agent. Sort of like prescribing nitroglycerin as an abortive.......

I see what you're saying Pegg. I was only trying to say that I don't think it's actually a vasodialtor, but a "relaxer" like my girlfriend Vera.

Aside from all of that: I know this goes against the grain of the general thinking around here, but I'm not convinced that vasodialtion/constriction is the key. Verapamil is believed by some to act on the hypothalamus to help us in lieu of it's vascular effect only. Same with the Triptans. High flow O2 is my best friend, but I can't help wonder if it's effect is more far reaching than just constriction.

I'd have to dig up the articles, but there enough researchers saying this to give me pause. Nitro is an exception that I can't explain, but there is still a lot that we don't know.

Cat has linked to a plethora of articles on this subject several times.

Marc

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