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Callico

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Nitric Oxide
Oct 14^th, 2010 at 10:00pm

I know that nitroglycerin is an instant trigger for CH, and that it is made in small amounts in the human body. It also breaks down into Nitric Oxide which causes smooth muscle relaxation and blood vessel expansion. It is the release of Nitric Oxide that Viagra generates for men with ED which I understand can also be a trigger for CH. My question is this then, Could it be a development and release of NO that causes CH attacks?

This thinking was brought on by doing some reading on Dr Ignarro's work on NO and the cardiovascular system. I'm looking for something to replace statins for cholesterol, but this is causing second thoughts about pursuing NO.

I don't recall having read anything about NO being involved with CH, but that means nothing. Would one of you more learned ones please weigh in on this?

I may be barking up totally the wrong tree, but it made sense to me. (Be warned)

Thanks much.

Jerry

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dougW

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pain is inevitable.
suffering is optional

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Re: Nitric Oxide
Reply #1 - Oct 14^th, 2010 at 11:46pm

Jerry:

Ask your Doc about Niacin:
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Lots of other articles out there.

Other than the flushing effect, there really are no side effects and I've not had any problems while in cycle.

Doug

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Out beyond wrong doing and right doing there is a field of luminous consciousness. I'll meet you there. (Rumi)

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Kevin_M

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Re: Nitric Oxide
Reply #2 - Oct 15^th, 2010 at 2:09am

Callico wrote on Oct 14^th, 2010 at 10:00pm:

I don't recall having read anything about NO being involved with CH, but that means nothing. Would one of you more learned ones please weigh in on this?

I'll crash in anyway, which of course won't help with your situation.

Quote:

I'm looking for something to replace statins for cholesterol

Quote:

Could it be a development and release of NO that causes CH attacks?

We observed a higher phenotype frequency of this allele in our control group compared with rates in control groups of other studies, whereas the frequency in our patients was similar to that in controls from previous reports. Thus, we conclude that it is unlikely that genetic variations within the NOS genes contribute greatly to cluster headache susceptibility.

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also same as abstract from: Analysis of Nitric Oxide Synthase Genes in Cluster Headache
Cephalalgia November 2002 22: 758-764,

Nitric oxide (NO) may participate in the mechanisms underlying vascular headaches, such as migraine and cluster headache ...

... but other factors are likely to render CH patients hyperresponsive to NO, and ultimately to cause the occurrence of pain and associated features.

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a neurovascular model could be more precise considering some recent experimental and clinical research data as serotoninergic neuromediation involvement, nitric oxide one and a possible genetic predisposition.

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George CH.com Moderator CH.com Alumnus Offline Black-Billed Magpie Posts: 8126 Boise, Idaho USA Gender:	Re: Nitric Oxide Reply #3 - Oct 27^th, 2010 at 11:26am Quote: Hi Jerry I found something about CH and NO. Multimedia File Viewing and Clickable Links are available for Registered Members only!! You need to or Howdy, Neils. Nice blog. Best, George
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Potter CH.com Alumnus Offline Team MOOSE DROOL Stinky Stuff on a Hook Prostaff Posts: 3600 Blgs.Mt. Gender:	Re: Nitric Oxide Reply #4 - Oct 27^th, 2010 at 11:53am Neils meet Timothy. You guys need a meet-n-greet for a really long walk in the sun. Potter
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George CH.com Moderator CH.com Alumnus Offline Black-Billed Magpie Posts: 8126 Boise, Idaho USA Gender:	Re: Nitric Oxide Reply #5 - Oct 27^th, 2010 at 12:29pm Quote: Hi Jerry I found something about CH and NO. Multimedia File Viewing and Clickable Links are available for Registered Members only!! You need to or Just curious, Neils...what part of "found" is "I wrote it myself"? Best, George
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Potter CH.com Alumnus Offline Team MOOSE DROOL Stinky Stuff on a Hook Prostaff Posts: 3600 Blgs.Mt. Gender:	Re: Nitric Oxide Reply #6 - Oct 27^th, 2010 at 4:43pm Quote: Hi I just got a mail from Niels. He has been CH free for almost 2 years after taking 200 µg vitamin D3 and 500 mg magnesium chloride pr. day. Before starting supplementing he had about 140-200 CH days pr. year since 1990. Do you hear voices in your head? Potter
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Guiseppi CH.com Moderator CH.com Alumnus Offline San Diego to Florida 05-16-2011 Posts: 12063 SAN DIEGO, CALIFORNIA USA Gender:	Re: Nitric Oxide Reply #7 - Oct 27^th, 2010 at 4:51pm Roses are red, Violets are blue, I'm schizophrenic, And so am I!!! I kill myself, really I do!!!!! Joe
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Potter CH.com Alumnus Offline Team MOOSE DROOL Stinky Stuff on a Hook Prostaff Posts: 3600 Blgs.Mt. Gender:	Re: Nitric Oxide Reply #8 - Oct 27^th, 2010 at 4:54pm Guiseppi wrote on Oct 27^th, 2010 at 4:51pm: Roses are red, Violets are blue, I'm schizophrenic, And so am I!!! I kill myself, really I do!!!!! Joe I added two more after reading it again. Potter
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Callico CH.com Hall of Famer Offline Author of "Stranded at Romson's Lodge Posts: 4916 Aurora IL Gender:	Re: Nitric Oxide Reply #9 - Oct 27^th, 2010 at 7:01pm Maybe he's been listening to an oldies station. Wasn't it the Chi-Lites who sang "A Letter to Myself"? Jerry Edit to add: If I take all that vitamin D plus walk three hours in the mid-day sun in Jan in Chicago, won't I overdose on Vitamin D???
Back to top	« Last Edit: Oct 27^th, 2010 at 7:02pm by Callico » "Political correctness is a doctrine, fostered by a delusional, illogical minority, and rabidly promoted by an unscrupulous mainstream media, which holds forth the proposition that it is entirely possible to pick up a piece of dung by the clean end." Texas A&M Student (unknown) IP Logged

Brew CH.com Sponsor CH.com Alumnus Offline Posts: 14163	Re: Nitric Oxide Reply #10 - Oct 27^th, 2010 at 7:11pm Not in January. The azimuth isn't steep enough..
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George CH.com Moderator CH.com Alumnus Offline Black-Billed Magpie Posts: 8126 Boise, Idaho USA Gender:	Re: Nitric Oxide Reply #11 - Oct 27^th, 2010 at 11:35pm Quote: Hi I just got a mail from Niels. He has been CH free for almost 2 years after taking 200 µg vitamin D3 and 500 mg magnesium chloride pr. day. Before starting supplementing he had about 140-200 CH days pr. year since 1990. Dude, we know it's you. Just in case the previous replies were too subtle. Best, George
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Guiseppi CH.com Moderator CH.com Alumnus Offline San Diego to Florida 05-16-2011 Posts: 12063 SAN DIEGO, CALIFORNIA USA Gender:	Re: Nitric Oxide Reply #12 - Oct 28^th, 2010 at 9:46am Which Seinfeld episode was it where the guy at the gym always talked in the third person.....Joe thinks this is a bad idea, Joe thinks he needs more sun, Joe thinks he's going to stop taking dangerous meds and over dose on milk! Joe
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George

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Re: Nitric Oxide
Reply #13 - Oct 28^th, 2010 at 11:30am

Quote:

Hi

Niels feel sorry for you, that you have to take dangeous medicine, when there is a naturaly way to get rit of the pain. Cry

Quote:

If I take all that vitamin D plus walk three hours in the mid-day sun in Jan in Chicago, won't I overdose on Vitamin D?

The answer is very simple. NO

George says he thinks it's worthwhile to save Neils's responses as quotes for posterity. Neils has a tendency to make 'em go "poof" after the fact. Or at least Neils did when he was "Neils", "D-3", and "Haug".

Best,

George and me.

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« Last Edit: Oct 28^th, 2010 at 11:38am by George »

"Whoever loveth me, loveth my hound." (Thomas More, author of "Utopia", and Chancellor of England. 1477-1535)

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Jimi CH.com Moderator CH.com Alumnus Offline Don't feed the moderators Posts: 4925 Madisonville, KY Gender:	Re: Nitric Oxide Reply #14 - Oct 28^th, 2010 at 11:44am Quote: Niels feel sorry for you Thats ok....Jimi and I feel sorry for you too.
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Callico CH.com Hall of Famer Offline Author of "Stranded at Romson's Lodge Posts: 4916 Aurora IL Gender:	Re: Nitric Oxide Reply #15 - Oct 28^th, 2010 at 11:55pm Sounds like a schitzophrenic convention going on here. (Not that I can spell schitzophrenic, but me, myself and I are one) Jerry
Back to top	"Political correctness is a doctrine, fostered by a delusional, illogical minority, and rabidly promoted by an unscrupulous mainstream media, which holds forth the proposition that it is entirely possible to pick up a piece of dung by the clean end." Texas A&M Student (unknown) IP Logged

George CH.com Moderator CH.com Alumnus Offline Black-Billed Magpie Posts: 8126 Boise, Idaho USA Gender:	Re: Nitric Oxide Reply #16 - Oct 30^th, 2010 at 8:38am Looks like Niels deleted his profile and all his posts again. He does that. Glad we saved some of his posts by quoting them. History can be cool. Best, George
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Melissa CH.com Moderator CH.com Alumnus Offline Don't give up! Posts: 7238 Central WI, USA Gender:	Re: Nitric Oxide Reply #17 - Oct 30^th, 2010 at 9:14am Jerry, I hope you got your question answered? Sorry for the craziness. mel
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