Copied from the "We Are Wellness insight Journal"
Pharmacology and Mechanisms of Action:
Valerian has an affinity for GABAA receptors, likely due to the relatively high GABA content in valerian itself. The amount of GABA present in valerian extract is sufficient to induce release of GABA in synaptosomes and may also inhibit GABA reuptake.

Other believed mechanisms of action in valerian include inhibition of the catabolism of GABA by valerenolic acid and acetylvalerenolic acid and affinity for the 5-HTA receptor by another constituent of valerian, called hydroxypinoresinal.

Due to the herb’s historical use as an anti-convulsant, sedative, migraine treatment and pain reliever, most basic research has been focused on the interaction of valerian constituents with the GABA neurotransmitter. The findings of these studies remain inconclusive. Thus, the true mechanism of action of valerian remains unknown


I would be curious to hear our more "educated and research minded" board members chime in. I did a little internet research on this and several sites spoke of it being used as an anti epileptic, anti seizure, and a sleep aid. Cross uses for several of our CH meds.......

Joe

i tried valproic acid for a couple years until i became toxic to it...lost my hair and balance (vertigo)

Duing the trial i did have lower kips but still remained pretty much chronic.


p

When I read these kind of threads, I admit, I'm usually very skeptical. But based on what I've read in this short thread, I wouldn't totally discount it. If it is related to Depakote, and others are finding relief from Depakote (Which I never did), It just may help some individuals, but I don't think there is just 1 'cure-all' that will help all sufferers.

Glad to hear it helped someone and maybe someone else will try it and also find relief.