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Control The Beast With O2 & D3 You Must
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ANC,
There are a couple things to try in order to improve the preventative effects of the anti-inflammatory regimen while you're waiting to see an endocrinologist.
The first is the baking soda tonic... Your systemic pH may be at the low end of the normal range (too much acid) for one reason or another.
As this condition can trigger a level of vasodilation that makes most cluster headache abortives and preventatives ineffective, drinking a baking soda tonic 4 to 5 times a day should neutralize enough stomach acid to elevate your systemic pH to the alkaline side of neutral (above a pH of 7.4). A systemic pH above 7.4 acts as a vasoconstrictor so it should make preventatives and abortives more effective.
In other words, drinking a tonic made with a half teaspoon of good old Arm & Hammer baking soda in 4 ounces of cold water four times a day, (2 hours after eating), and right before bed might just do the trick... The directions are on the box.
If you don't have any baking soda (sodium bicarbonate - NaHCO3), try an Alka-Seltzer. It contains a combination of aspirin, citric acid, and sodium bicarbonate (baking soda). When dissolved in water or the stomach, it has pH is 9.2 so should make short work of a low systemic pH condition.
If a low systemic pH is not the problem, it's possible calcium homeostasis is preventing 25(OH)D from being metabolized in the kidneys into the active hormonal form of vitamin D3, 1,25(OH)2D3 (calcitriol).
Calcium homeostasis and vitamin D3 metabolism are interrelated processes that work together to maintain the total calcium serum concentration in a very narrow range.
As the total calcium serum concentration approaches the upper end of the normal range, this condition signals the parathyroids to slow or stop production of PTH (parathyroid hormone)...
As PTH is essential in the metabolism of 25(OH)D into calcitriol, a drop in PTH slows or stops production of calcitriol and that can stop or hinder the preventative effect we get from vitamin D3.
As calcitriol is also essential for pulling calcium from the gut and pushing it into the blood stream, a drop in calcitriol results in a drop of the total calcium serum concentration.
As these two processes are autonomous and run all on their own... the only thing we can do is bias them by changing the intake of vitamin D3 and or calcium supplements.
As your 25(OH)D was ≥92 ng/mL, and that should be high enough to prevent your CH if it's being metabolized into calcitriol. Stopping the the intake of calcium supplements for a week or so should increase production of calcitriol and that should increase the preventative effect of vitamin D3.
Hmmm... I know that may be confusing... Just chalk it up to better living through chemistry... and a yin-yang thing that maintains total calcium serum concentration in a very narrow range...
In short, skip the calcium supplements for a week and see what happens. If you're eating a well-balanced diet you're likely getting sufficient calcium to maintain bone mineral density.
Now if that wasn't confusing enough, there's another path where 25(OH)D is metabolized into calcitriol, but it doesn't occur in the kidneys... It called the autocrine mode of vitamin D3 metabolism that enables gene transcription and it takes place at the cellular level within all the different types of body cells...
In this case, the metabolism of 25(OH)D into calcitriol is controlled by retinol (vitamin A - β-carotene) not PTH. Magnesium and zinc are also essential in this process.
Vitamin A is hard to find, but it's readily available in other formulations like Centrum Silver, the "old foggy" vitamin and mineral supplement. (That's what I take)... You can also get it from the carotenoids found in carrots, sweet potatoes, spinach, kale, collard greens, papaya, bell peppers, and tomatoes.
Hope this helps...
Take care and please keep us posted...
V/R, Batch
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