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New CH.com Forum › Cluster Headache Help and Support › Medications, Treatments, Therapies › Signifor

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Signifor (Read 1921 times)

PaulV CH.com Newbie Offline I Love CH.com! Posts: 5 New Zealand	Signifor Apr 29^th, 2013 at 5:30pm Hi all, I'm wondering whether anyone on the CH board has any knowledge of, or experience with Signifor - a relatively new medicine made by Novartis? Kind regards Paul
Back to top	Cluster Headache: Currently replacing Topiramate with Verapamil. Oxygen, when needed. Trigeminal Neuralgia: Gabapentin + Baclofen [They've tried: Red Bull, GTN, Entenox, Chlorpromazine, Rizatriptin, Sumitriptan, Amitriptyline, Nortriptyline, Indomethacin, Topiramate, Carbamazepine, Prednisone] IP Logged

Guiseppi CH.com Moderator CH.com Alumnus Offline San Diego to Florida 05-16-2011 Posts: 12063 SAN DIEGO, CALIFORNIA USA Gender:	Re: Signifor Reply #1 - Apr 30^th, 2013 at 7:00am Did a board search and yours is the first post here on it. Did a web search, and saw it's primariy use is for Cushings. Started trying to read the info on it but it's a whisker over my head! Joe
Back to top	"Somebody had to say it" is usually a piss poor excuse to be mean. IP Logged

Mike NZ CH.com Hall of Famer Offline Oxygen rocks! D3 too! Posts: 3785 Auckland, New Zealand Gender:	Re: Signifor Reply #2 - May 1^st, 2013 at 2:34pm Google now has this topic as the first results when searching for "signifor cluster headache". From what I've read I'm confused as to why it could help with CH. Can you tell us more about what your neuro said about using it to treat CH?
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PaulV

CH.com Newbie

Offline

I Love CH.com!

Posts: 5
New Zealand

Re: Signifor
Reply #3 - May 3^rd, 2013 at 7:12am

A Google Search for European Patent EP1941902A1 gives a document which describes a medicine called pasireotide, which is marketed as Signifor® by Novartis.

Unfortunately, the document is highly technical, but phrases such as:
[0014]
Two small randomized, double-blind trials suggested efficacy of somatostatin in cluster headache. The problem with studying native somatostatin as a potential abortive agent for CH is that its short half-life of several minutes necessitates an intravenous infusion.

[0015]
Octreotide, a octapeptide somatostatin analog with a longer half-life of approximately 1.5 hours, can be given subcutaneously, and has been studied as an abortive agent for the acute treatment of CH (M. S. Matharu et al., Ann Neurol. 2004; 56; 488-494

[0020]
In addition, pasireotide is a smaller molecule than octreotide (consisting of 8 vs. 6 amino acids) and is less lipophilic than octreotide (partition coefficient log p = 2.7 vs. 5.5). Both factors contribute to a better cell permeability of pasireotide which thus could reach pain sensitive structures within the central nervous system by crossing the blood brain barrier more easily than octreotide.

got me all excited.

The patent is from 2008, and they're marketing the drug for Cushing's Disease.
So, I've written to Novartis to see what's going on.
Was hoping that someone on the message board would have some experience with it (from CH perspective) to help put their eventual answer in perspective.

Kind regards
Paul V

Cluster Headache: Currently replacing Topiramate with Verapamil.
Oxygen, when needed.
Trigeminal Neuralgia: Gabapentin + Baclofen
[They've tried: Red Bull, GTN, Entenox, Chlorpromazine, Rizatriptin, Sumitriptan, Amitriptyline, Nortriptyline, Indomethacin, Topiramate, Carbamazepine, Prednisone]

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PaulV

CH.com Newbie

Offline

I Love CH.com!

Posts: 5
New Zealand

Re: Signifor
Reply #4 - May 3^rd, 2013 at 7:21am

Hi, a quick PS.
I've just noticed that my previous message included a (R) symbol, and the name of a major pharmaceutical company. I hope this doesn't make me look like a drug pimp! I even managed to slip the name into the last message twice. So, for the record: NovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartis
NovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartis
NovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartis
NovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartis
NovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartisNovartis
NovartisNovartis, etc

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Guiseppi CH.com Moderator CH.com Alumnus Offline San Diego to Florida 05-16-2011 Posts: 12063 SAN DIEGO, CALIFORNIA USA Gender:	Re: Signifor Reply #5 - May 3^rd, 2013 at 7:24am You didn't come across as a pimp! Does look like there's potential there.... Joe
Back to top	"Somebody had to say it" is usually a piss poor excuse to be mean. IP Logged

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