Hey Filipus,

Good question. A link between having CH and having a history of fevers may not be all that far fetched if you follow my logic below.

Since posting about the anti-inflammatory regimen with 10,000 IU/day vitamin D3 in December of 2010, we've collected user comments from several hundred CH'ers using this regimen.

80% of the CH'ers who start and stay on this regimen experience a significant reduction in the frequency, severity and duration of their CH. 75% experience pain free days and 60% remain pain free.

This is a safe and healthy vitamin and mineral regimen.  There have been no adverse events reported that required medical attention.

The shear volume of empirical data collected to date suggest a causal relationship between a vitamin D3 deficiency and cluster headache.

Finding what prevents the other 20% from responding to this regimen has been an ongoing effort.  I spent a good bit of time researching the pharmacokinetics and pharmacodynamics of vitamin D3, (what the body does to vitamin D3 and what it does to the body).  I also spoke with several endocrinologists expert in treating vitamin D3 deficiencies. 

What emerged was that any insufficiency of the GI tract, liver, kidneys, thyroid, parathyroid and pancreas  could easily prevent the absorption and metabolism of vitamin D3. 

Data from the online survey of 110 CH'ers using this regimen suggested another possible spoiler that could prevent vitamin D3 from preventing CH...  inflammation associated with viral and bacterial infections, i.e., upper and lower respiratory infections like colds and flu.  Allergic reactions are also suspect.

It turns out that our immune system's T-Cells are major consumers of the vitamin D3 metabolites, 25(OH)D, and the hormonally active metabolite, 1,25(OH)2D3. 

During viral and bacterial infections, (they're usually accompanied by fever), T-Cells sensitized by the infection source and stimulated by vitamin D3, multiply rapidly into an army of Pack Man-like cells roaming around the body gobbling up the offending virus/bacteria and any infected cells.   

Connecting the dots... a high white blood cell count usually indicates some kind of infection...

Accordingly... getting back to your question...  there is a possible relationship between CH and a history fever...  However, if you follow the discussion above, it should be clear that fever is a symptom and not the cause of CH, but it is indirectly related.

It's the viral or bacterial infection and the immune response they trigger, not the fever that consumes available vitamin D3 metabolites.  When 25(OH)D reserves are depleted by the immune system's response to these infections, if you're predisposed to cluster headaches...  you get them.

There are a few takeaways from this discussion:  If you have cluster headaches, see your PCP for a lab test for 25(OH)D.  The normal reference range for this lab test is 30 to 100 ng/mL, (75 to 250 nmol/L).

If the results come back below 60 ng/mL, (150 nmol/L) start vitamin D3 therapy by taking the anti-inflammatory regimen...  There's an 80% probability you'll have a favorable response.

You can find all you need to know about this regimen at the following link:

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Response time to this regimen vary from 24 hours to as long as two months...  Over 50% of CH'ers respond in the first week after starting this regimen and 75% have responded by the end of the first month after starting. Stay on this regimen if you do respond and remember, it's only a preventative and not a cure.

Take care,

V/R, Batch