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New CH.com Forum › Cluster Headache Help and Support › Medications, Treatments, Therapies › Anti-CRGP approved for episodic CH

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Anti-CRGP approved for episodic CH (Read 1771 times)

Mike NZ

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Anti-CRGP approved for episodic CH
Jun 6^th, 2019 at 2:58am

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Worth reading through the full article to get all the info.

Quote:

Results showed that the Emgality group saw a significant difference in their weekly attacks compared with placebo.

Between Weeks 1 and 3 of the two-month treatment period, those receiving Emgality had 8.7 fewer cluster headache days vs. 5.2 fewer days for placebo; (p=0.36).

Three out of four participants (76%) who were treated with Emgality had at least a 50% reduction in weekly cluster headache attacks compared to 57% for the placebo at Week 3, the secondary endpoint.

Also, 73% of patients treated with Emgality reported improvements based on the Patient Global Impression of Improvement (PGI-I) at Week 4, compared to 46% for the placebo.

Interesting results when you compare the effects to the placebo, with placebo doing pretty well when you consider that there is no active pharmaceutical, with all changes being due to the power of the mind.

Every single advance will help some people with CH get to lead more normal lives as a result.

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AussieBrian CH.com Hall of Famer Offline CH - It's all in your head! Posts: 3851 Cairns, Qld, Australia Gender:	Re: Anti-CRGP approved for episodic CH Reply #1 - Jun 6^th, 2019 at 4:59am Give me a bucket full of that placebo!!! With a success rate of 46-57% it beats the pants off any medication I ever tried!
Back to top	My name is Brian. I'm a ClusterHead and I'm here to help. Email me anytime at briandinkum@yahoo.com IP Logged

Mike NZ

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Re: Anti-CRGP approved for episodic CH
Reply #2 - Jun 7^th, 2019 at 8:36pm

AussieBrian wrote on Jun 6^th, 2019 at 4:59am:

Give me a bucket full of that placebo!!!

With a success rate of 46-57% it beats the pants off any medication I ever tried!

It isn't always that simple. Placebo treatments are associated with side effects, even withdrawal effects!

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AGeNT_1212

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Re: Anti-CRGP approved for episodic CH
Reply #3 - Jun 11^th, 2019 at 12:49pm

Whats strange about this approval is the testing period appears to have been for 2 months, and episodic clusters lasting for 2-10 weeks average...

So in some of these sufferers their cycles likely were degrading naturally, and were taken as the result of the drug

This could be why it 'works' for episodics and not chronics.

I think in some cases even with other treatments that 'seem' to work, its actually the cycle degrading naturally. Shocked

Just a thought.

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Mike NZ CH.com Hall of Famer Offline Oxygen rocks! D3 too! Posts: 3785 Auckland, New Zealand Gender:	Re: Anti-CRGP approved for episodic CH Reply #4 - Jun 11^th, 2019 at 7:03pm Hi AGeNT_1212 and welcome Well spotted too. We all know how a lot about CH can vary, which can include cycle duration, so I can see your logic as to why it "works" for episodic but not chronic CH.
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AGeNT_1212 CH.com Newbie Offline I Love CH.com! Posts: 2 NY Gender:	Re: Anti-CRGP approved for episodic CH Reply #5 - Jun 12^th, 2019 at 1:13pm Its probably why the placebo was also 'effective' Thanks for the welcome, I'm actually quite ye ole vet on the message boards, here and CB. O2 FTW
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Mike NZ

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Oxygen rocks! D3 too!

Posts: 3785
Auckland, New Zealand
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Re: Anti-CRGP approved for episodic CH
Reply #6 - Jun 14^th, 2019 at 2:45am

AGeNT_1212 wrote on Jun 12^th, 2019 at 1:13pm:

Its probably why the placebo was also 'effective'

Placebos are virtually always effective for some people, this is not unique to the experiment design or the condition being treated. Similarly people getting a placebo will often get a range of side effects which are attributed to the placebo.

It can be incredibly interesting reading up about the placebo effect and the complexities it can introduce to good trial design and results analysis.

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