Hey Lynn,
Thanks for the update. Yes, another 3 to 4 more days loading vitamin D3 at 50,000 iU/day might just do the trick. Just remember to see your PCP/GP or neurologist 30 days after starting this regimen.
Are you taking all the cofactors and did you double the magnesium dose to 800 mg/day while loading split 400 mg in the morning with breakfast and 400 mg with the evening meal?
What brand/form of vitamin D3 are you taking? Many CHers, me included, have found the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 is faster acting with a higher bioequivalence than the oil-based liquid softgel vitamin D3 formulations.
How about the 3-month course of vitamin B 100 complex? The updated version of this treatment protocol will now suggest Methyl Folate plus in place opf the vitamin B 100 complex. It's a formulation of Methyl Folate, Methylcobalamin (B12), Niacin, B1, B2 & B6.
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These are the same B vitamins suggested by Dr. Stasha Gominak, MD in her headache and sleep regimen and Dr. Cicero Coimbra, MD, PhD, in his vitamin D3 treatment protocol for MS. After the 3-month course of these B vitamins, there are sufficient amounts of the same vitamins in the Kirkland Adult 50+ Mature Multi to prevent any deficiencies. There's no problem taking the Kirkland Mature Multi with the Methyl Folate plus. It will just replete any deficiencies a little faster.
With a starting baseline 25(OH)D3 serum concentration of 16 ng/mL, you would need a total loading dose of 800,000 IU of vitamin D3 to reach an initial 25(OH)D3 serum concentration target of 96 ng/mL. Taken at a loading dose of 50,000 IU/day, that's a loading schedule of 16 days as a minimum. Accordingly as you've already completed 12 days at 50,000 IU/day and seven days at 20,000 IU/day, I would still try 3 to 4 more days on the loading schedule taking 50,000 IU/day vitamin D3 before dropping back to 15,000 IU/day as an initial maintenance dose.
You may be fighting an allergic reaction. Allergic reactions are common this time of year and the culprit is usually leaf mold spores. That said it could be a reaction to something you're eating. In any case, I would start a week to 10 day course of a first-generation antihistamine like Benadryl (Diphenhydramine HCL) at 25 mg every four hours throughout the day.
Allergic reactions release histamine and it triggers the expression of CGRP, SP, VIP and PACAP in neurons throughout the brain. These are the four neuroactive peptides that studies have found to be responsible for the neurogenic inflammation and pain we know as CH. First-generation antihistamines cross the blood brain barrier to block histamine H1 receptors at the genetic layer in neurons throughout the brain and trigeminal ganglia in particular. This should should slow the expression of these four peptides enough to give vitamin D3 a chance to further reduce their expression.
Just be careful and not drive as this much Diphenhydramine will make you drowsy. If you do need to drive during the day, wait until you're home for the day, then take 50 mg Benadryl (Diphenhydramine HCL) as you walk through the door and another 50 mg at bedtime.
As an extra measure, I would avoid eating any wheat products and all sugars for the next month. No fruit juices or grain oils like Canola or Mazola. Fruit juices contain a lot of fructose we don't really need. The grain oils likely contain Gliphosate from Roundup ready GMO seeds. Drinking 2.5 liters of water a day is also a must at this stage of the treatment protocol.
I've sent you a PM with additional information.
Take care and please keep me posted.
V/R, Batch
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