Genes


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Posted by Ted (205.188.197.153) on December 12, 1999 at 13:23:58:

In Reply to: family history posted by Dorothy on December 12, 1999 at 08:29:10:

I don't believe that it plays a big role in the chances of developing CHs or not, but it can play a role. Below I've pasted some corresponding info on it:

Cluster headache is an autosomal dominantly inherited
disorder in some families: a complex segregation analysis
MB Russell, PG Andersson, LL Thomsen and L Iselius
Department of Neurology, University of Copenhagen, Denmark.
We investigated the mode of inheritance of cluster headache in 370 families. The probands
were from a neurological clinic in Jutland and two departments of neurology in Copenhagen
County, Denmark. The criteria of the International Headache Society were used. The patterns of
segregation of cluster headache were assessed by complex segregation analysis performed with
the computer program POINTER. Of the 370 probands with cluster headache, 25 had 36
relatives with cluster headache. The segregation analysis suggests that cluster headache has an
autosomal dominant gene (p < 0.10) with a penetrance of 0.30-0.34 in males and 0.17-0.21 in
females. The gene is present in 3 to 4% of males and 7 to 10% of females with cluster
headache. An autosomal dominant gene has a role in cluster headache in some families.

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Journal of Neurology, Neurosurgery, and Psychiatry, 1995, Vol 58, 341-343
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PAPERS
Familial occurrence of cluster headache
MB Russell, PG Andersson and LL Thomsen
Department of Neurology, Glostrup Hospital, Unversity of Copenhagen, Denmark.
The familial occurrence of cluster headache was assessed in 421 patients with cluster
headache, diagnosed according to the operational diagnostic criteria of the International
Headache Society. The patients were recruited from a neurological clinic and two departments
of neurology, covering east central Jutland and Copenhagen County respectively. They received
a mailed questionnaire regarding the presence of cluster headache among their first and second
degree relatives. All possibly affected relatives were interviewed by telephone. The response rate
to the questionnaire was 88% (370/421). Seven patients belonged to three families. A positive
family history of cluster headache was found in 7% (25/366) of the families. Compared with
the general population, the first and second degree relatives of the 370 patients with cluster
headache had a 14-fold and twofold increase in the risk of having cluster headache after
standardisation for sex and age. This increase in familial risk strongly suggests that cluster
headache has a genetic cause.
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1995 by Journal of Neurology, Neurosurgery, and Psychiatry





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