Induced Attacks

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Posted by Q ( on January 31, 2000 at 18:13:10:

In Reply to: HEY ! something I'd almost forgotten - REALLY related to this topic posted by gary on January 31, 2000 at 16:14:58:

The Medical Information write-up (on the left) says:

Experimentally, attacks can be triggered in nearly all patients during a bout by the administration of 1 mg nitroglycerin sublingually (Ekbom, 1968), and in about 70 percent of patients by subcutaneous histamine (Horton, 1961). There is usually a latent period of 30 to 50 minutes before headache is triggered, whereas the peak peripheral and central vascular effects of nitroglycerin occur within 3 to 4 minutes of its administration and disappear in approximately 30 minutes (Bogaert, 1987). This, the appearance of headache does not coincide with the maximal circulatory effect of nitroglycerin, and the mechanism by which nitroglycerin causes headache remains unclear. A period refractory to pharmacologic provocation occurs after spontaneous or pharmacologically induced attacks and may persist for 2 hours or more (Ekbom, 1968; Horton, 1961). Therefore, valid provocative tests must be administered during an active bout, several hours after the attack has subsided.

Gary, I would add the histimine to the list and find out what all three have in common: alcohol, nitro, and histimine.

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