Posted by drummer (209.105.155.54) on March 24, 2000 at 17:23:25:
In Reply to: amitryptaline still working posted by bobt on March 24, 2000 at 17:08:27:
This looks like the stuff you and I were talking about. Very interesting. Also known as Elavil; as you mentioned to me. Below is how it works. I bolded some interesting words.
Clinical Pharmacology:
Amitriptyline HCl is an antidepressant with sedative effects. Its mechanism of action in man is not known. It is not a monoamine oxidase inhibitor and it does not act primarily by stimulation of the central nervous system.
Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. Pharmacologically this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activity. This interference with the reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of amitriptyline.