Gotcha - well got me too to be honest. Got us both in fact!

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Posted by Flash ( on May 01, 2000 at 18:30:21:

In Reply to: Disagree posted by Bob P on May 01, 2000 at 13:42:58:


This is a link I got from you:

Now it backs up what both of us are saying. Here are some excerpts (how the fuck do you spell excert?):

For You:
The recent introduction of sumatriptan (Imitrex) as the first 5-HT1D receptor agonist represents a major advance in the treatment of acute migraine attacks. Migraine headaches affect nearly one in 11
Americans, occurring usually in adults 35-45 years of age.

During the prodromal phase of an attack, 5-HT is spontaneously released from platelets. It enters the vessel wall, causing arterial
vasoconstriction and lowering the pain threshold. In the absence of 5-HT, extracranial arteries dilate and distend, resulting in a headache.

Sumatriptan selectively constricts carotid arterial circulation supplying blood to extracranial and intracranial tissues such as meninges, dilation of which is thought to contribute to migraines

For me:
methysergide, used to prevent migraine headaches, is a potent 5-HT2 antagonist
Many hallucinogenic substances such as LSD and psilocin are thought to block serotonin, but, obviously, not all central 5-HT antagonists are hallucinogens. A clinically investigated 5-HT2 antagonist,
ketaserin, has been found to be an effective anti-hypertensive agent but is not selective since it may also block alpha1-andrenoreceptors. (Depends on wether you subscribe to LSD being a treatment).

For both of us:
Migraines. Two experimental "5-HT1-like" agonists (AH 25086 and GR 43175) are being clinically investigated for the treatment of acute migrains. These agents act by activating 5-HT1 receptors that
mediate localized vasoconstriction within the carotid vascular bed and appear to be more selective than ergotamine. In addition, 5-HT3 antagonists have been shown to possess effectiveness in migraines.

Against both of us:

This basically says that Prozac isn't primarily an agonist - oops! Cringe.

Selective inhibitors of serotonin uptake
Fluoxetine (Prozac) Antidepressant, OCD

Serotonin receptor agonists
Sumatriptan (Imitrex) Migraine headaches

Serotonin receptor antagonists
Methysergide Migraine headaches

I think we are looking at three sides of a triangle if you get my drift.

On the suicide front, an ex-girlfriend of mine OD'd when taking Prozac for depression. Unfortunatley she recovered, but the doc said that Prozac had been shown to cause people to 'act on impulse'. So no it doesn't make you top yourself, but if you are depressed and the thought 'pops' into your head, then Prozac may contribute to making it a reality. I think we can share the points on that one!

Anway - Cheryl the answer on Prozac is basically umm err FUCK KNOWS?

You can try this one first! I'm not getting into that shit again LOL...


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