Triptans and mushrooms

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Posted by pinksharkmark ( on September 25, 2001 at 14:55:08:

In Reply to: URGENT 4 Flash,Pinky,or anyone who might help,pleeeeez posted by Bryan on September 25, 2001 at 11:01:13:

Flash thinks it is best to wait 5 days after Imitrex or Maxalt or Zomig or Amerge before taking the tea. I think 24 to 72 hours of being free from all triptans may be enough. The thing is, nobody KNOWS for sure. Flash may be right, or I may be right, or it may be that the triptans don't interfere at all (although this is pretty unlikely... the chemistry of the triptans is such that I am almost positive that they WILL block the action of psilocybin, just not sure for how long)

The thing is, I know (BELIEVE me I know) how hard it is not to reach for the Imitrex. Try as hard as you can not to take any for AT LEAST 24 to 48 hours before the shrooms. Longer is better.

For those who have enough mushrooms (or LSD) readily available, and just can't bear the prospect of going five days with no Imitrex, there is a possible compromise. Note that I recommend this approach only as a last resort... total abstinence from Imitrex and other triptans for at least 72 hours would give a much better chance of success with the first dose of mushrooms.

My compromise:

Try as hard as you can not to take any of the triptans for 24 hours before dosing, then go ahead. Even if the Imitrex DOES interfere with the mushrooms, they MIGHT still work PARTIALLY. The first dose may knock the level of the pain down to a level where you can handle the CH with just tylenol or oxygen, allowing you to do without Imitrex for the mandatory 4 or 5 day waiting period before your followup dose of mushrooms.

The second dose would therefore be done under "triptan-free" conditions, and should finish the job nicely.

Again, I must stress that this is certainly NOT my preferred method. It is quite clear from the abundant posts on this board that those who were COMPLETELY med-free at the time of dosing got the best results, so don't be disappointed if you get NO results at all with this compromise approach. As Flash warns, it might very well be a total waste of psilocybin.


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