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Posted by Jim R on October 27, 2001 at 19:26:27:

What is the proposed mechanism of cluster headache?

Currently, the exact mechanism of cluster headache remains uncertain. The sphenopalatine ganglion and cavernous sinus are among the sites previously considered potentially important for cluster headache pathogenesis. Most recently, PET scanning techniques have revealed the hypothalamic region as important in cluster headache pathogenesis (May, 1998). Critical serotonergic function, which regulates the biological clock, may also be altered (Leone, 1997).

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