OUCH Research Library

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Posted by Bob P ( on November 27, 2001 at 10:20:35:

In Reply to: Saw a new Neuro today WOOHOO!!! posted by Wendy on November 26, 2001 at 20:08:46:

This is from an article that I added to the OUCH Library this past weekend: Naratriptan: The 'Gentle Triptan'Naratriptan has a relatively slow onset of action and appears to have a somewhat lower headache response at 2 hours than some other triptans. However, it is associated with the lowest headache recurrence rate of the currently available triptans (see Differential features table).[1] The low recurrence rate may be enhanced in those patients who use naratriptan early in a migraine attack, treat less severe attacks and obtain complete pain relief.[9] The incidence of triptan sensations, and all adverse effects, with naratriptan is very low. In fact, in some cases the incidence of adverse events was lower with naratriptan than with placebo. Therefore, naratriptan has been referred to as 'the gentle triptan'. Furthermore, because naratriptan is metabolised by a variety of cytochrome P450 enzymes and not the MAO system, it is not associated with significant drug interactions.[1,2]

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