Posted by Margi (22.214.171.124) on November 30, 2001 at 14:12:14:
In Reply to: Anyone know the Half-Life of Verapamil ? posted by Doug on November 30, 2001 at 14:06:53:
I found the answer to your question by pressing my brower's search button and typing in 'Verpamil Half Life' into the box. The answer was in the first article I found. We're a support group here, but ya gotta help yourself a little too.
I'll give you this one, but next time search on your own a little, ok? The answer I found is:
The mean elimination half-life in single-dose studies ranged from 2.8 to 7.4 hours. In these same studies, after repetitive dosing the half-life increased to a range from 4.5 to 12 hours (after less than 10 consecutive doses given 6 hours apart). Half-life of verapamil increases during titration due to saturation of hepatic enzyme systems as plasma verapamil levels rise. Aging affects the pharmacokinetics of verapamil. Elimination half-life is prolonged in the elderly.
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