There is a heredity factor ...

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Posted by Bob P ( on January 14, 2002 at 09:22:42:

In Reply to: I was just wondering!!?? posted by bob baker on January 13, 2002 at 22:14:37:

but it is small. Here is a copy of a study that was done. Dr. Goadsby is also looking into the heredity factor.
Heritability of cluster headache.

Montagna P, Mochi M, Prologo G, Sangiorgi S, Pierangeli G, Cevoli S, Cortelli P

Institute of Clinical Neurology, University of Bologna, Italy.

We conducted a pedigree analysis in 222 patients with cluster headaches (CHs) in order to assess a familial predisposition to the disease. Heritability was determined by Falconer’s index (from the incidence of CH among first degree relatives of probands compared with a control population), which varies between 0 and 1 (none or full genetic causation).A positive family history (I/II degree relatives) was found in 2.3% of our
CH patients. Three generations were affected in one family and two generations in another two families. The calculated Falconer’s heritability index was, however, only 0.26 +/- 0.25 SD. Our study confirms a higher familial occurrence of CH, some families showing a pattern compatible with autosomal dominant inheritance with reduced penetrance. The low Falconer’s index indicates, however, a large non-genetic causation in most cases of CH.

PMID: 10210856, UI: 99338339

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