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   Author  Topic: Fresh Research - Sumatriptan and Heart Attack  (Read 192 times)
floridian
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Fresh Research - Sumatriptan and Heart Attack
« on: Dec 29th, 2005, 12:33pm »
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Pediatr Cardiol. 2005 Jul-Aug;26(4):464-6.  
 
    A case of myocardial infarction with sumatriptan use.
 
    Erbilen E, Ozhan H, Akdemir R, Yazici M.
 
    Department of Cardiology, Faculty of Medicine, Abant Izzet Baysal University Duzce, Kardiyoloji Klinigi, Konuralp, Turkey.
 
    Sumatriptan is widely used in the treatment of acute attacks of cluster headache. It is a serotonin-1 (5HT-1) agonist. Several studies have reported an association between sumatriptan use and myocardial infarction, possibly due to the generalized vasoconstrictive nature of this agent. We report a 16-year-old male patient presenting with acute inferior myocardial infarction after sumatriptan use without any known risk factors of coronary artery disease.
 
    PMID: 16374699 [PubMed - in process]
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #1 on: Dec 29th, 2005, 12:41pm »
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Thanks, bro.  Don't all/most of the triptan meds carry the same risk?  
 
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floridian
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #2 on: Dec 29th, 2005, 12:53pm »
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on Dec 29th, 2005, 12:41pm, Gator wrote:
Thanks, bro.  Don't all/most of the triptan meds carry the same risk?  
 

 
They are all vasoconstrictors and have some risk - the standard answer is that in 90% of people (those without certain heart conditions) they are acceptably low risk.  But a 16 year old kid with no known risk factors??
« Last Edit: Dec 29th, 2005, 12:57pm by floridian » IP Logged
nani
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #3 on: Dec 29th, 2005, 1:10pm »
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on Dec 29th, 2005, 12:53pm, floridian wrote:

 
  But a 16 year old kid with no known risk factors??  

 
That is scary as hell!  
Those of you who use a lot of triptans... especially the smokers...
please reconsider.  Undecided
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #4 on: Dec 29th, 2005, 7:22pm »
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I saw this report when I checked PubMed today and decided to not post it. It's not wise to jump to conclusions about any med based on one case and, especially here, we have no other information about underlying issues which have not been reported.  
 
We have multiple reports covering thousands of people using this class of meds showing high levels of safety and effectivenesss.  
 
Life is a constant balancing of cost/benefit and it's important to not lose sight of this reality. Whether we are taking an aspirin, driving a car, or taking an anesthetic for a dental procedure--there is risk.
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #5 on: Jan 1st, 2006, 9:44am »
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Bob, spoken like a true philosophic clinician.  My mother-in-law, bless her little pea-pickin' brain, reads every single warning on every single thing that she ingests.  She always has side-effects.  And they are always listed somewhere on the pt info pamphlet.  She is a truly amazing subject for study.  On the other hand, those who take tripans daily, and have other risk factors, really should keep this in mind.  Some of the clusterbuster methods don't have the risk involved, and might be worth checking into.  For the record though, Imitrex has saved the lives/sanity of many.
It is all about weighing the risks vs. benefits.
kathy
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #6 on: Jan 1st, 2006, 11:11am »
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on Jan 1st, 2006, 9:44am, kcopelin wrote:
 On the other hand, those who take tripans daily, and have other risk factors, really should keep this in mind.  Some of the clusterbuster methods don't have the risk involved, and might be worth checking into.  
kathy

 
Please try to convince our Viking Hero Svenn to at least consider some clusterbuster methods as he fall in the high risk category and uses triptans daily and in high dosages.
 
 
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clustersurgeon
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #7 on: Jan 1st, 2006, 1:33pm »
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I was the First in the worlds who talk about that;
You can see cluster migraine surgery on Challenger Sat TV on Hotbird,  
From Padova, ITALY www.migrainesurgery.8m.net
Happy New Year.
Where you can reads about trpitans Danger.
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #8 on: Jan 1st, 2006, 1:44pm »
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]
For the attention of anyone new reading this.
 
ClusterSurgeon is a troll.
 
He has registered on this site under many names and deleted all of them after being run off for dangerous, ridiculous and worthless views.
 
He is not a doctor.
 
He has no medical training and his so called medical certification comes from schools with no medical education programmes.

Do not be deceived.
 
His opinion and views are worth their weight in manure so unless you have roses read no further!
 
Oh and he does not have cluster headaches so if you are looking for help his views are of no value to you.
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #9 on: Jan 2nd, 2006, 5:50am »
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on Jan 1st, 2006, 11:11am, Jasmyn wrote:

 
Please try to convince our Viking Hero Svenn to at least consider some clusterbuster methods as he fall in the high risk category and uses triptans daily and in high dosages.
 
 

 
 
 
 
The neuroes and cardioes here saying that triptans"imitrex" is NOT that bad for the heart as first expected.
 
Have asked a lot of docs about my situation and in summary they say that i can do up to 5 shots a day without any problem.
 
I believe we need to read the warnings on the manuals inside the cases with new eyes since most of the warnings is from when trex first come to us early 90s
 
 
 
 
Svenn
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #10 on: Jan 2nd, 2006, 10:45am »
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on Jan 2nd, 2006, 5:50am, Svenn wrote:

 
 
 
 
The neuroes and cardioes here saying that triptans"imitrex" is NOT that bad for the heart as first expected.
 
Have asked a lot of docs about my situation and in summary they say that i can do up to 5 shots a day without any problem.
 
I believe we need to read the warnings on the manuals inside the cases with new eyes since most of the warnings is from when trex first come to us early 90s
 
 
 
 
Svenn

 
That still does not stop me from worrying about you, you stubborn Viking! Wink
I agree, as CHers we do tend to be on higher dosages of meds and survive but the Clusterbusters have delivered great results with less harm over the past few years.
 
 
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #11 on: Jan 2nd, 2006, 2:36pm »
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Headache. 2004 Feb;44(2):178-82.  
 
   
Frequent triptan use: observations on safety issues.
 
Robbins L.
 
Department of Neurology, Rush Medical College, Chicago, Ill. 60062, USA.
 
OBJECTIVE: To examine the safety of frequent triptan use over extended periods. For a small group of patients with refractory migraine plus chronic daily headache, triptans are effective. METHODS: This retrospective study primarily evaluated the cardiac safety of daily triptan use in 118 patients and, in addition, hematologic tests were assessed. Each patient had utilized a triptan for a minimum of 4 days per week for at least 6 months. Patients with rebound headache had been withdrawn from the triptans. Most patients (97 of 11Cool averaged 1 tablet daily; most would occasionally go for several days without a triptan. Forty patients had taken a triptan for 6 months to 2 years, 37 patients from 2 to 4 years, and 41 for 4 or more years. RESULTS: Routine hematologic tests were performed periodically on all patients, and no abnormalities were attributable to triptans. Almost all patients had an electrocardiogram, and no abnormal electrocardiograms were felt to be related to triptans. Cardiac echocardiography was performed in 57 patients. The 10 abnormal echocardiograms were not due to triptans. All 20 cardiac stress tests revealed normal findings. Adverse events were minimal; 9 patients described fatigue due to triptans, and 5 had mild chest tightness. CONCLUSION: This long-term study of 118 patients indicates that frequent triptan use may be relatively safe.
 
PMID: 14756859 [PubMed - indexed for MEDLINE]  
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Re: Fresh Research - Sumatriptan and Heart Attack
« Reply #12 on: Jan 5th, 2006, 9:51am »
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Thanks for this - O2 and clusterbusters makes complete sense for me 'coz they work better than the triptans I've been prescibed.
 
The fact that they're much less likely to lead to heart disease  is a side effect I will be able to live with.
 
Anyone for Lithium or Pizotifen/Sanomigran?  
 
The latter's side effects include - Dry mouth, fast heartbeat, difficulty urinating (passing water), constipation, drowsiness, increased appetite and weight gain, feeling sick, dizziness, skin rashes, swelling of the limbs, muscle pains, pins and needles, sexual problems, seeing or hearing things that are not real, or very rarely depression.
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