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Topic: SSRI & Bleeding Risk (Read 806 times) |
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Bob_Johnson
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SSRI & Bleeding Risk
« on: Dec 3rd, 2004, 12:21pm » |
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This is NOT a reason to stop using SSRIs--but it is a cautionary note to not increase doses without your doc's knowledge and to pay attention to any wound, etc. which may induce blood loss.
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Nov. 24, 2004 — New users of selective serotonin reuptake inhibitors (SSRIs) have 2.6-fold increased risk of being admitted to the hospital for abnormal bleeding, according to the results of a nested case-control study published in the Nov. 22 issue of the Archives of Internal Medicine.
"Serotonin plays a role in platelet aggregation. Because antidepressants influence blood serotonin levels, their use may be associated with an increased risk of abnormal bleeding," write Welmoed E. E. Meijer, PhD, from the Utrecht Institute for Pharmaceutical Sciences in the Netherlands, and colleagues. "However, previous studies were inconclusive regarding this association."
Using data collected from 1992 through 2000, the investigators conducted a nested case-control study of a cohort of more than 64,000 new antidepressant users. The 196 cases, defined as all patients hospitalized for a primary diagnosis of abnormal bleeding, were matched with controls for age and sex. Exposure was classified according to the degree (high, intermediate, or low) of serotonin reuptake inhibition.
Based on logistic regression analysis, the risk of hospitalization increased with the use of inhibitors providing intermediate (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1-3.5) and high degrees of serotonin reuptake inhibition (OR, 2.6; 95% CI, 1.4-4. .
The primary limitation of this study is possible misclassification related to diagnosis from hospital records, and inability to detect bleeding events that did not result in hospitalization or that resulted in death before the patient came to the hospital.
"In a large population of new antidepressant users we found a significant association between degree of serotonin reuptake inhibition by antidepressants and risk of hospital admission for abnormal bleeding as the primary diagnosis," the authors write. "An increased risk of abnormal bleeding was strongly associated with the degree of serotonin reuptake inhibition."
The authors report no financial conflicts of interest.
Arch Intern Med. 2004;164:2367-2370
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| « Last Edit: Dec 3rd, 2004, 4:45pm by Bob_Johnson » |
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Bob Johnson
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becky8
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Bob,
Thanks for the good info!
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forgetfulnot
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Now I'm really depressed 
Lee
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