A headache may appear to be a Cluster but can, in reality, be a medical condition which is far more serious, even life threatening. This suggests that we need a good diagnostic work-up before we assume Cluster and before we start treating the headache as Cluster.
Here are a few abstracts which are case examples of how Cluster-LIKE headaches (the term used in the literature) can be seriously misleading.
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Cephalalgia. 2010 Jun 8.
Positional CLUSTER-LIKE headache. A case report of a neurovascular compression between the third cervical root and the vertebral artery.
Créac'h C, Duthel R, Barral F, Nuti C, Navez M, Demarquay G, Laurent B, Peyron R.
Université Lyon 1, France.
Abstract
Symptomatic CLUSTER-LIKE HEADACHES have been described with lesions of the trigeminal and parasympathetic systems. Here, we report the case of a 44-year-old woman with continuous auricular pain and a positional cluster-like headache associated with red ear syndrome. Clinical data and morphological investigations raised the hypothesis of a neurovascular compression between the C3 root and vertebral artery. Neurosurgical exploration found a fibrosis surrounding both the C3 root and the vertebral artery. The excellent outcome after microvascular cervical decompression suggests a causal relationship between the cluster-like headache and the vertebral constraint on the C3 root.
PMID: 20974591 [PubMed - as supplied by publisher]
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Emerg Med J. 2010 Oct 20.
Acute coronary syndromes can be a headache.
Costopoulos C.
Abstract
Ischaemic heart disease is a common cause of morbidity and mortality worldwide. Patients typically present with chest pain and breathlessness either on exertion or at rest. Cardiac ischaemia can also lead to headache, although this is very rarely its only manifestation. Headache is MOSTLY ASSOCIATED WITH MIGRAINE, CLUSTER AND TENSION headache disorders. MORE SINISTER CAUSES INCLUDE SUBARACHNOID HAEMORRHAGE, TEMPORAL ARTERITIS, MENINGITIS, VENOUS SINUS THROMBOSIS AS WELL AS VERTEBRAL AND CAROTID ARTERY DISSECTION. A case of headache is presented where the underlying cause was cardiac ischaemia, itself the result of triple vessel coronary artery disease. This, also referred to as cardiac cephalgia, should be suspected in the older patient with risk factors for atherosclerotic disease presenting with recent-onset headache. Diagnosis of this requires high clinical suspicion and is essential for correct patient management.
PMID: 20961932 [PubMed]
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Title: "Cluster Headache Mimics"--useful article. Post by Bob_Johnson on Jul 30th, 2004, 2:04pm
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This is an important article to obtain and take to your doctor if you are having a difficult time getting a diagnosis of the type of headache problem you have and/or finding medications which give consistent relief for cluster. It is a technically difficult read for someone not educated in medicine. Its value is in providing case studies about uncommon conditions which appear to be cluster headache but which are, in fact, not.
Broad signs which may signal that the problem being treated is a cluster mimic are: having made a diagnosis of cluster, the standard medications do not work OR they work for an episode or two and then stop being effective. Second, if the diagnostic signs differ in important ways from the standard signs for cluster (and this is a subtle issue which requires a physician with sophistication).
One of the striking findings reported: Cluster can arise from head trauma as long as 30-years after the trauma!
Some conditions which can mimic primary cluster headache:
Infections
Aspergillus
Inflammatory disorders
Wegener's granulomatosis
Orbital myositis
Plasmacytoma
Multiple sclerosis
Head trauma
Vascular abnormalities
Arterial dissections
Arteriovenous malformations
Neoplasms
Pituitary tumors
Metastases
Other trigeminal autonomic cephalgias: SUNCT syndrome; Paroxysmal hemacrania; Hypnic headache
"Cluster Headache Mimics", Dale M. Carter, M.D.. CURRENT PAIN AND HEADACHE REPORTS, 2004, 8:133-139.
(Take this citation to your public library and they can order a copy of the complete article for you.)
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Cephalalgia. 2010 Apr;30(4):399-412. Epub 2010 Feb 15.
Cluster-like headache. A comprehensive reappraisal.
Mainardi F, Trucco M, Maggioni F, Palestini C, Dainese F, Zanchin G.
Headache Centre, Neurological Division, SS. Giovanni e Paolo Hospital, Venice, Italy. federico.mainardi@ulss12.ve.it
Abstract
Among the primary headaches, cluster headache (CH) presents very particular features allowing a relatively easy diagnosis based on criteria listed in Chapter 3 of the International Classification of Headache Disorders (ICHD-II). However, as in all primary headaches, possible underlying causal conditions must be excluded to rule out a secondary cluster-like headache (CLH). THE OBSERVATION OF SOME CASES WITH CLINICAL FEATURES MIMICKING PRIMARY CH, BUT OF SECONDARY ORIGIN, led us to perform an extended review of CLH reports in the literature. We identified 156 CLH cases published from 1975 to 2008. THE MORE FREQUENT PATHOLOGIES IN ASSOCIATION WITH CLH WERE THE VASCULAR ONES (38.5%, N = 57), FOLLOWED BY TUMOURS (25.7%, N = 38) AND INFLAMMATORY INFECTIOUS DISEASES (13.5%, N = 20). Eighty were excluded from further analysis, because of inadequate information. The remaining 76 were divided into two groups: those that satisfied the ICHD-II diagnostic criteria for CH, 'fulfilling' group (F), n = 38; and those with a symptomatology in disagreement with one or more ICHD-II criteria, 'not fulfilling' group (NF), n = 38. Among the aims of this study was the possible identification of clinical features leading to the suspicion of a symptomatic origin. In the differential diagnosis with CH, red flags resulted both for F and NF, older age at onset; for NF, abnormal neurological/general examination (73.6%), duration (34.2%), frequency (15.8%) and localization (10.5%) of the attacks.
WE STRESS THE FACT THAT, ON FIRST OBSERVATION, 50% OF CLH PRESENTED AS F CASES, PERFECTLY MIMICKING CH. THEREFORE, THE IMPORTANCE OF ACCURATE, CLINICAL EVALUATION AND OF NEUROIMAGING CANNOT BE OVERESTIMATED.
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More cases which make it clear that we need caution in diagnosis and more skill than many of our docs possess.
--
Cephalalgia. 2010 May 17.
Mere surgery will not cure cluster headache - implications for neurostimulation.
Hidding U, May A.
University Medical Centre Hamburg Eppendorf, Germany.
Abstract
This case study concerns a patient with primary chronic cluster headache, who was unresponsive to all treatments and consecutively underwent hypothalamic deep brain stimulation (DBS). DBS had no effect on the cluster attacks, but cured an existing polydipsia as well as restlessness. However, hypothalamic DBS produced a constant, dull headache without concomitant symptoms and a high-frequent tremor. All of these effects were repeated when the stimulation was stopped and than started again. DBS had no effect on a pathological weight gain from 70 kg to 150 kg due to bulimia at night, usually during headache attacks.
THIS CASE ILLUSTRATES THAT CLUSTER HEADACHE IS, IN SOME PATIENTS, ONLY ONE SYMPTOM OF A COMPLEX HYPOTHALAMIC SYNDROME.
This case also underlines that the stimulation parameters and anatomical target area for hypothalamic DBS may be too unspecific to do justice to the clinical variety of patients and concomitant symptoms. Hypothalamic DBS is an exquisite and potentially life-saving treatment method in otherwise intractable patients, but needs to be better characterised and should only be considered when other stimulation methods, such as stimulation of the greater occipital nerve, are unsuccessful.
PMID: 20974592 [PubMed
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J Neurol. 2010 Oct 26. [Epub ahead of print]
Trigeminal autonomic cephalalgia sine headache.
Haane DY, Koehler PJ, Te Lintelo MP, Peatfield R.
Department of Neurology, Atrium Medical Centre, PO Box 4446, 6401 CX, Heerlen, The Netherlands, ass641@atriummc.nl.
Abstract
Cluster headache without headache (CH-H) has been described several times. We add three new CH-H patients and a patient with (probable) paroxysmal hemicrania without headache (PH-H). We searched the literature and found some more cases of CH-H and PH-H. CH-H attacks may have a shorter minimal attack duration than CH attacks. We propose the term trigeminal autonomic cephalalgia without headache (TAC-H) for autonomic attacks and/or extracephalic pain or sensory symptoms with an attack duration and distribution and/or response to therapy suggesting one of the trigeminal autonomic cephalalgias, but without accompanying headache. Secondary TAC-H may develop after treatment for painful TAC attacks. We discuss pathophysiological issues, particularly the central role of the hypothalamus and the suggestion that the superior salivatory nucleus (SSN) might be triggered by the diencephalic pacemaker without nociceptive activation.
PMID: 20976466 [PubMed
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Acta Neurol Scand. 2010 Apr 8.
Secondary chronic cluster headache due to trigeminal nerve root compression.
Mjåset C, Bjørn Russell M.
Head and Neck Research Group, Research Centre, Akershus University Hospital, Lørenskog, Norway.
Abstract
Mjåset C, Bjørn Russell M. Secondary chronic cluster headache due to trigeminal nerve root compression. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2010.01322.x. (c) 2010 The Authors Journal compilation (c) 2010 Blackwell Munksgaard. A 50-year-old woman had a gradual onset of chronic headache located in the right temporal region and a burning sensation in the root of the tongue which over a year evolved into chronic cluster headache with a milder chronic headache in-between the severe cluster headache attacks. A cerebral magnetic resonance imaging (MRI) showed vascular compression of the trigeminal nerve root on the pain side. Neurosurgery microvascular decompression relieved the patient?s chronic cluster headache, the chronic intermittent headache and the burning tongue sensation. The effect was persistent at a 1 year follow-up. PATIENTS WITH ATYPICAL SYMPTOMS OF CLUSTER HEADACHE SHOULD BE EXAMINED WITH CEREBRAL MRI ANGIOGRAPHY OF ARTERIES AND VEINS TO EXCLUDE SYMPTOMATIC CAUSES.
PMID: 20384588 [PubMed]
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Emerg Med J. 2011 Jan;28(1):71-3. Epub 2010 Oct 20.
ACUTE CORONARY SYNDROMES CAN BE A HEADACHE.
Costopoulos C.
SourceDepartment of Medicine, Addenbrooke's Hospital, Cambridge, UK. ccostopoulos@doctors.org.uk
Abstract
Ischaemic heart disease is a common cause of morbidity and mortality worldwide. Patients typically present with chest pain and breathlessness either on exertion or at rest. Cardiac ischaemia can also lead to headache, although this is very rarely its only manifestation. Headache is mostly associated with migraine, cluster and tension headache disorders. More sinister causes include subarachnoid haemorrhage, temporal arteritis, meningitis, venous sinus thrombosis as well as vertebral and carotid artery dissection. A case of headache is presented where the underlying cause was cardiac ischaemia, itself the result of triple vessel coronary artery disease. This, also referred to as cardiac cephalgia, should be suspected in the older patient with risk factors for atherosclerotic disease presenting with recent-onset headache. Diagnosis of this requires high clinical suspicion and is essential for correct patient management.
PMID:20961932[PubMed ====[Added 11/9/11]
BMJ Case Rep. 2008;2008:bcr0720080444. Epub 2008 Nov 20.
Cluster headache or giant cell arteritis?
Baskar S, Etti R, Kitas G, Klocke R.
SourceDudley Group of Hospitals, Rheumatology, Russel's Hall Hospital, Dudley, DY1 2HQ, UK.
Abstract
We describe an elderly female patient with known polymyositis who presented with new onset temporal headache that was diagnosed as giant cell arteritis but subsequently had a typical clinical course of cluster headache. This case illustrates the potential for diagnostic confusion between giant cell arteritis (GCA) and cluster headache (CH) and the need to consider CH as a potential differential diagnosis in those newly presenting with headaches, even in the elderly, and relapsing headaches in subjects with a diagnosis of GCA. Importantly, this needs to include female patients, a group historically thought to be much less likely to develop CH.
PMID:21716821[PubMed]
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This link will take you to a German source (with mix of German and English titles). These mimics of Cluster are rare, even exotic, but for the intellectually curious it suggests just how many conditions can present as Cluster headaches.
Multimedia File Viewing and Clickable Links are available for Registered Members only!! You need to

or

======Following posted 3/19/12===
Neurol Sci. 2009 May;30
Headache and multiple sclerosis: clinical and therapeutic correlations.
La Mantia L.
SourceIstituto Nazionale Neurologico C. Besta, Via Celoria, 11, 20133, Milan, Italy. lamantia@istituto-besta.it
Abstract
Headache is not generally considered as a symptom of multiple sclerosis (MS), but several studies have showed that it is more frequent (about 50%) in MS patients than in controls or general population. Headache may occur at onset and during the course of the disease. Tension-type headache and migraine without aura are the most commonly reported primary headaches; occipital neuralgia or cluster-like attacks have also been described, the location of demyelinating lesions (cervical or brain stem) could be strategic in these cases. Furthermore, disease-modifying therapies, such as interferons, may cause or exacerbate headache. These data suggest that MS patients have an increased risk of headache. Preventive therapies may be evaluated in selected patients during chronic treatments to ameliorate compliance.
PMID:19415421[PubMed]
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One value of this report: clue that a headache is not Cluster--when standard CH meds are not effective, in full or in part.
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J Pain Symptom Manage. 2009 Feb;37(2):271-6.
Chronic cluster-like headache secondary to prolactinoma: uncommon cephalalgia in association with brain tumors.
Benitez-Rosario MA, McDarby G, Doyle R, Fabby C.
SourceUnidad de Cuidados Paliativos, Hospital La Candelaria, Tenerife, Spain. mabenros@gmail.com
Abstract
Headache is a common and disabling aspect of pituitary disease. Chronic and episodic migraine are the most common clinical syndromes of headaches related to pituitary tumors, although other types of headache, such as trigeminal autonomic cephalalgias (TACs), can also be present. TACs include short-lasting, unilateral neuralgiform headache attacks with conjunctival injection and tearing; paroxysmal hemicrania; and cluster headache.
WE REPORT ON A PATIENT WITH A CHRONIC CLUSTER-LIKE HEADACHE ASSOCIATED WITH A MACROPROLACTINOMA. ALTHOUGH CABERGOLINE, PREGABALIN, AND CORTICOSTEROIDS WERE NOT EFFECTIVE AS PREVENTIVE TREATMENTS, HIGH-DOSE VERAPAMIL SHOWED GOOD EFFICACY. MORPHINE AND OCTREOTIDE WERE EFFICACIOUS AS ABORTIVE TREATMENTS FOR ATTACKS, BUT PAIN WAS ONLY PARTIALLY RESPONSIVE TO OXYGEN AND REFRACTORY TO SUBCUTANEOUS SUMATRIPTAN.
PMID:18694630[PubMed]
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Cephalalgia. 2010 Dec;30(12):1509-13.
Positional cluster-like headache. A case report of a neurovascular compression between the third cervical root and the vertebral artery.
Créac'h C, Duthel R, Barral F, Nuti C, Navez M, Demarquay G, Laurent B, Peyron R.
SourceUniversité Lyon 1, France. christelle.creach@univ-st-etienne.fr
Abstract
Symptomatic cluster-like headaches have been described with lesions of the trigeminal and parasympathetic systems. Here, we report the case of a 44-year-old woman with continuous auricular pain and a positional cluster-like headache associated with red ear syndrome. Clinical data and morphological investigations raised the hypothesis of a neurovascular compression between the C3 root and vertebral artery. Neurosurgical exploration found a fibrosis surrounding both the C3 root and the vertebral artery. The excellent outcome after microvascular cervical decompression SUGGESTS A CAUSAL RELATIONSHIP BETWEEN THE CLUSTER-LIKE HEADACHE AND THE VERTEBRAL CONSTRAINT ON THE C3 ROOT.
PMID:20974591[PubMed]
===========================
Neurologist. 2012 Jul;18(4):206-7.
Cluster headache and parietal glioblastoma multiforme. [BJ: group of abnormal growths with varying characteristics.]
Edvardsson B, Persson S.
SourceDepartment of Neurology, Faculty of Medicine, Lund University Hospital, Lund, Sweden.
Abstract
INTRODUCTION: : Cluster headache (CH) is a primary headache by definition not caused by any known underlying structural pathology. However, symptomatic cases have been described. The evaluation of CH is an issue unresolved.
CASE REPORT: : A 41-year-old man presented with a 3-month history of side-locked attacks of excruciating severe stabbing and boring right-sided pain located in the temple and the orbit. The attacks were associated with conjunctival injection and restlessness and migrainous features. The duration of attacks was about 30 minutes and the frequency 4 to 5 per 24 hours. His vital signs and physical and neurological examination were normal. A previous unenhanced brain computed tomography had been normal. A diagnosis of CH was made. The patient responded partially to treatment. Enhanced magnetic resonance imaging after 3 weeks displayed a right-sided parietal glioma with a surrounding edema and mass effect. After debulking, the headache attacks resolved completely.
CONCLUSIONS: : Contrast-enhanced magnetic resonance imaging should always be considered in patients with CH despite earlier normal head computed tomography/examinations. Late-onset CH represents a condition that requires careful evaluation. Parietal glioblastoma multiforme can present as CH.
PMID:22735247[PubMed]
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(Message posted by a newbie who became a living example of a rare possibility! BJ)
Bfingles
CH.com Newbie 1/24/14
Re: Diagnosed with Cluster headaches a week ago
Reply #6 - Today at 12:22pm So I thought I would update everyone. First I appreciate all the folks who reached out to help and offer advise. As it turns out I was miss diagnosed. After reading all the posts on this website I realized I did not fit into the cluster headaches diagnosis. I continued to push my Neurologist and he eventually sent me to the Stanford pain clinic (I highly recommend this clinic for anyone suffering any kind of headache pain including cluster headaches) They quickly determined that I did not fit in to a classic symptoms and order a fiesta MRI, which revealed that I had cancer (missed on the 2 previous readings of my MRI), it is a rare form of Squamacell carcinoma that went in instead of out and attached itself to my Trigeminal nerve causing all of the pain. Just finishing radiation and chemo treatments now, future looks good and I'm glad I have answers. The moral to the story is keeping pushing to make sure you have been diagnosed properly and get relief form your pain.
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This is not a comprehensive list of disorders which mimic Cluster. I stopped adding to this list because it would just not stop growing! And my intention has been to just provide an indication of how complex making an accurate diagnosis of Cluster can be--a list long enough to tease the reader and their docs into awareness.