Hey Raww,
Thanks for the update and additional info on the supplements you take. The 2-Week and 4-Week vitamin D3 loading schedules each call for 600,000 IU taken over two or four weeks. This should result in an average 25(OH)D response of 60 ng/mL (150 nmol/L) on top the staring/baseline 25(OH)D serum concentration.
The following chart illustrates the starting 25(OH)D serum concentration reported by participants in the anti-inflammatory survey prior to start of regimen. It represents the normal bell shaped distribution curve.
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The odds are your starting 25(OH)D serum concentration fell between 13 and 33 ng/mL (32 and 55 nmol/L). Accordingly, if you completed either the 2-Week or 4-Week vitamin D3 loading schedule, your 25(OH)D serum concentration would have been 73 to 93 ng/mL (182.5 to 232.5 nmol/L). It will be interesting to see your lab results.
You should note that your 25(OH)D serum concentration will drop rapidly as soon as you stop taking vitamin D3 as 25(OH)D has a half-life of two to three weeks. In other words, if you stopped taking vitamin D3 with a 25(OH)D serum concentration of 73 ng/mL (182.5 nmol/L)... three weeks later it would be 38 ng/mL (95 nmol/L). Moreover, we need to maintain a 25(OH)D serum concentration of at least 80 ng/mL (200 nmol/L) in order to experience a lasting CH pain free response to this regimen.
The rest of your supplements look about right except I would switch to a liquid soft gel form of vitamin D3, add the 3-month course of vitamin B 50 complex, and start a week to 10 day course of a good first-generation antihistamine like Diphenhydramine (Benadryl). .
The powdered form of vitamin D3 may be just fine... However, as vitamin D3 is fat soluble, the liquid soft gel form of vitamin D3 may have a higher bioavailability.
Regarding Pizotifen... It is widely used as prophylaxis in children with migraine, but there are no studies listed in clinicaltrials.gov assessing its efficacy in preventing migraine much less cluster headache. A review in the BMJ Clinical Evidence concluded that although pizotifen is almost universally used for paediatric migraine, there is no evidence from well-conducted trials that it is beneficial. See link below:
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That said, there's a very long list of adverse effects from taking pizotifen. Accordingly. I'd suggest asking your neurologist about switching to the leading CH preventative, verapamil...
Regarding overdosing on vitamin D3... It's realy hard to do unless there's a problem with the parathyroid glands...
If someone has hyperparathyroidism, an abnormally high concentration of parathyroid hormone (PTH) in the blood caused by an adenoma (benign tumor) on one of the four parathyroid glands, even 3,000 IU/day vitamin D3 could be too much resulting in hypercalcemia.
Most vitamn D3 experts claim we would need to take ≥ 50,000 IU/day for roughly three months to experience vitamin D3 intoxication as indicated by a calcium serum concentration above its normal reference range, (hypercalcemia).
Then there's Dr Cicero Coimbra, MD, Ph.D, a neurologist in Saó Paulo, Brazil who treats his Multiple Sclerosis (MS) patients with a protocol very similar to the anti-inflammatory regime we take to prevent our CH with a few major exceptions.
The big differences are he prescribes 1000 IU of vitamin D3 per Kg of body weight a day. For a sleek rascal like me weighing in around 210 lbs (95 Kg), I'd be taking 95,000 IU/day vitamin D3 on the Coimbra protocol... That dose is 10 times higher than I suggest to prevent CH...
His protocol calls for a complete avoidance of calcium supplements and calcium rich foods (milk, cheese and other milk products). He also requires his patients drink 2.5 liters of water a day to help flush any excess calcium from the kidneys.
I've spoken with one of Dr. Coimbra's MS patients and she indicated the labs for 25(OH)D are basically useless as nearly all of the 25(OH)D assay methods are only capable of measuring 25(OH)D serum concentrations up to 150 to 165 ng/mL (390 to 413 nmol/L).
It is also important to note that none of Dr. Coimbra's MS patients, (over 2000 of them) have experienced vitamin D3 toxicity/hypercalcemia as long as they stick with the treatment protocol. 95% of his MS patients on this protocol are in complete remission from MS living normal lives with a very good quality of life...
Hope this helps.
Take care and please keep us posted.
V/R, Batch
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