Hey General Cluster,

How much vitamin D3 are you taking and have you had a recent lab test of your 25(OH)D3 serum concentration?

I've spent over 10 years providing information outreach on the anti-inflammatory regimen to help thousands of CHers control their CH. I've found that when CHers don't respond to this regimen they're usually not taking enough vitamin D3 to elevate their 25(OH)D3 serum concentration high enough to experience a therapeutic effect with the cessation of their CH. 

The best way of determining this is the case is with lab tests for 25(OH)D3.  The following normal distribution curves for baseline and 30 day 25(OH)D3 serum concentrations of CHers who respond to this treatment protocol, illustrates they have a mean 25(OH)D3 serum concentration of 80 ng/mL within the first 30 days on this treatment protocol.
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The important take away from this chart is half of these CHers required a 25(OH)D3 serum concentration greater than 80 ng/mL with some as high as 180 ng/mL in order to experience a cessation of their CH.  Over the last 19 months since these graphics were posted, we've had several CHers report 25(OH)D3 serum concentrations over 250 ng/mL to achieve or maintain a CH pain free status.  I'm one of them as you'll see in the 4-year chart of my labs for 25(OH)D3, calcium and PTH.

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It's also important to note that even with 25(OH)D3 serum concentrations as high as mine at 277 ng/mL, my calcium serum concentration has remained within its normal reference range so no hypercalcemia, a.k.a., vitamin D3 intoxication/toxicity.

We've made a few changes in the type of vitamin D3 used in this treatment protocol.  In 2018 we switched to the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 from the oil-based liquid softgel vitamin D3 formulations.  We did this as the Bio-Tech D3-50 has a higher bioequivalence.   We switched from the vitamin B-50/100 complex to the Methyl Folate + vitamin B complex for the same reason. 

For the last 5 months many of us have added Micro D3, a liquid nano-emulsion of vitamin D3 that has an even higher bioequivalence when taken sublingual.  The new basic anti-inflammatory regimen supplements are illustrated in the following photo of what I take and suggest to other CHers.

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Many of us have found an accelerated vitamin D3 loading schedule taking two (2) of the Bio-Tech D3-50 capsules/day and 0.5 mL/day of the Micro D3 provides 140,000 IU/day of vitamin D3 for a rapid increase in 25(OH)D3 serum concentration between 60 and 70 ng/mL on top of the baseline 25(OH)D3 serum concentration when taken on a 5-Day loading schedule. 

We take this loading dose combination for a max of 5 days then drop back to an initial vitamin D3 maintenance dose of two (2) Bio-Tech D3-50 capsules/week (an average vitamin D3 maintenance dose of 20,000 IU/day)  then see our PCP/GP for labs of our serum 25(OH)D3, calcium and PTH.

The rationale for this new loading schedule is simple.  It elevates 25(OH)D3 a little higher in five days as opposed to the older loading schedule taking 50,000 IU for 12 days.

Take care and please keep us posted.

V/R, Batch