Aubanbird my old friend,
It's been too long. Howz my favorite supporter Akina? Please give her a hug for me.
Pattik is spot on. A healthy diet (Atkins-Ketogenic), lots of vitamin B complex, Melatonin and a good mix of friendly colonies in the microbiome by using a good probiotic daily to repopulate them can make a big difference in sleep patterns. I'd add that a daily 15 minute exercise routine can also help achieve restful sleep.
What is your present 25(OH)D3 serum concentration? There's no down-side and much to be gained by bumping serum 25(OH)D3 concentrations up around 150 ng/mL using a loading schedule of 100,000 IU/day for 6 days followed by a higher maintenance dose of at least 100,000 IU/week using the Bio-Tech D3-50.
The following link will take you to a study titled "Disassociation of Vitamin D’s Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double-Blind Clinical Trial."
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While the title of this study may be confusing, the results are very clear. Higher doses of vitamin D3 activate higher numbers of vitamin D3 genes. Specifically, they found a clear 25(OH)D3 dose response to maintenance doses of vitamin D3 in terms of the number of genes activated:
600 IU/day vitamin D3 activated 162 genes
4,000 IU/day vitamin D3 activated 320 genes
10,000 IU/day vitamin D3 activated 1289 genes
The authors of this study commented they should have used even higher doses of 20,000 IU/day and 30,000 IU/day to activate even more genes.
The bottom line from this study is clear, the higher the vitamin D3 dose, the greater number of genes activated. Moreover as researchers have found 2,776 binding sites for the vitamin D receptor along the length of the human genome, there's room to improve the total genes activated by higher doses of vitamin D3.
The latest version of the basic anti-inflammatory regimen shown below is essentially the same as published here at CH.com in December of 2011.
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That said, I have shifted vitamin D3 and vitamin B complex brands to gain higher bioavailability. Specifically, I shifted from the oil-based liquid soft gel vitamin D3 formulations to the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 capsules. I've also added the Nutrasal Micro D3 nano emulsion taken sublingual during loading schedules.
The Bio-Tech D3-50 has a bioequivalence easily twice that of the same dose of the oil-based liquid soft gel vitamin D3 formulations. The sublingual Micro D3 has three to four times the bioequivalence of the liquid soft gel vitamin D3 formulations. Moreover, when taken sublingual, it bypasses the GI tract passing directly into the blood stream in a matter of minutes
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I also shifted from the generic Vitamin B 50/100 complex Dr. Gominak suggested to the Methyl Folate + B complex, again for higher bioavailability.
If you opt for the loading schedule to elevate your serum 25(OH)D3, you'll need to double your magnesium by taking 400 mg with breakfast and a second 400 mg dose with the evening meal. This provides 12 hours and 12 feet GI tract separation between doses. This helps avoid the osmotic diarrhea associated with higher doses of magnesium.
It's also a good idea to see your PCP to obtain lab assays for your serum 25-Hydroxy Vitamin D3, a.k.a., 25(OH)D3, Calcium and Parathyroid Hormone (PTH). Ask that the orders for these labs be sent to the Quest Diagnostics facility nearest your home. The tests to ask for include the following:
• 25-Hydroxyvitamin D3 [25(OH)D3]. Quest Diagnostics Test Name: QuestAssureD 25-OH Vitamin D (Total), LC/MS/MS. Test Number 92888 and CPT Code 82306.
• Parathyroid Hormone (PTH) Intact and Total Calcium. CPT codes 83970, 82310
In March of this year I began suggesting a new second part of this treatment protocol initially to counteract immune system responses to allergens that prevent some CHers and many migraineurs from responding to this treatment protocol. I call it the Antihistamine Full Monty as it replaces the Benadryl (Diphenhydramine HCL). The Antihistamine Full Monty is a collection of supplements that among their many beneficial health properties like stimulating the vitamin D receptor (VDR) expression, they also function as antihistamines.
Nearly all of these supplements are also found in most naturopathic and nutritional treatments for migraines. The Full Monty is just as effective in combating the histamine released by allergic reactions and it has none of the drowsiness or adverse side effects associated with long term use of first-generation antihistamines.
We start the Antihistamine Full Monty with two (2) grams/day loading doses for one week of the first four supplements listed below. You can drop back to a maintenance dose of one (1) gram/day and stay at that dose until the allergens are gone or greatly reduced.
A. 2 Grams/day Turmeric (Curcumin)
B. 2 Grams/day Quercetin
C. 2 Grans/day Resveratrol
D. 2 Grams/day Omega-3 Fish Oil (EPA and DHA)
E. 250 mcg/day Selenium
F. 1000 mg/day N-Acetyl Cysteine (NAC)
G. 5 to 10 mg/day Melatonin (Taken at bedtime)
H. 8 Grams/day vitamin C
If fish oil poses a problem, I've found DHA-1000, one of the two Omega-3 fatty acids, to be an excellent alternative. I've used it this year with no problems.
I buy the bulk powdered vitamin C in 1 Kg or 2 lb jar as shown below and stir two level teaspoon measures (8 grams) in 12 oz of water. I drink a gulp of this solution every two hours throughout the day until it is gone by bedtime. This is the least expensive form of vitamin C at 3 to 4 cents/gram. The liposomal vitamin C costs 8 to 9 cents/gram.
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Sleep paralysis is an interesting and frightening condition. I experienced it twice while cramming for final exams at the University of Washington in 1966. In both cases I'd been on cramming stints of 24 to 36 hours without any sleep and too much coffee. It started shortly after lying down to sleep and the symptoms were exactly the same as you described them complete with hallucinations. That's the sum total of my experience with sleep paralysis so I've no experience treating it.
Sleep on the other hand is another story. At 78 and having spent a good part of my adult life on aircraft carriers, I'm quite proficient at it, particularly the hard part, getting to sleep.
Your post indicates you've seen your doctors and done your homework so I won't go into sleep hygiene. What I've found that helps me get to sleep rapidly is a high fat and carbohydrate snack like a slice of cherry pie with ice cream 45 minutes to an hour prior to bed time.
There's a shift in electrolytes as the stomach starts producing hydrochloric acid. There's also a spike in blood glucose followed by a spike in insulin as the carbohydrates reach the small intestine. The insulin, in turn, increases the amount of seratonin and melatonin that flood the brain. These two chemicals are associated with drowsiness (and, for that matter, happiness). All of the above can trigger a food coma to aid in getting to sleep.
To recap, try the latest version of the anti-inflammatory regimen with the Antihistamine Full Monty. Avoid Rx medications if possible. Eat a high carbohydrate snack an hour prior to bedtime.
Take care and please keep us posted.
V/R, Batch