Posted by Michel L (18.104.22.168) on October 31, 1999 at 18:18:19:
In Reply to: Topamax? what is it? posted by Christopher JC on October 31, 1999 at 18:02:15:
Part of 'Phamacology Online' specifications, this would be the part that may apply to CH (Topamax is primarily used in cases of epilepsies in children
and adults, including infantile spasms associated with West syndrome. :
The exact mechanism of topiramate's anticonvulsant
effects is unknown. It appears that topiramate may block the spread of
seizures rather than raise the seizure threshold like other AEDs.
Topiramate's anticonvulsant actions involve several mechanisms. First,
topiramate reduces the duration of abnormal discharges and the number of
action potentials within each discharge. This is probably secondary to its
ability to block voltage-sensitive sodium channels. Second, topiramate
enhances the activity of the inhibitory neurotransmitter gamma-aminobutyrate
(GABA) at GABA-A receptors by increasing the frequency at which GABA
activates GABA-A receptors. Third, topiramate inhibits excitatory
transmission by antagonizing some types of glutamate receptors.(end of citation).
My own opinion on this is that it should be very effective in jamming the sodium-potassium discharge that initiates an attack but it won't prevent a cycle in general. It would simply render the cycle painless.
I will soon submit some more of my findings about this. I am almost ready to submit my 'universal theory' about CH. (one more).
Pain free days,
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