Ah ha - some of your counter points I can clear up!!!

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Posted by Flash ( on July 26, 2000 at 16:25:56:

In Reply to: Well.. posted by Miguel on July 26, 2000 at 09:13:40:

"The other
question is: Are certain subtypes of 5-HT receptors
only supposed to be in certain tissues?"

Yes, the brain, heart and bowel have predominately different types of receptor. I think all types are present but the proportions vary from organ to organ.

"MPVS - myocardial ? ? syndrome? please explain." - Mitral Valve Prolapse Syndrome - see my response to the arrythmia post today.

"LSD is pretty much harmless if swallowed, as I understand.
You absorb it through your gums I think." - no you can take it in a number of ways. As an ex-recreational user I usually swallowed a small piece of cardboard that had been dipped in it. It wasn't in my mouth very long. My sister once swallowed a microdot, that was encased in plastic wrapper (she was meant to remove the wrapper first but didn't know any better), the trip kicked in after the wrapper dissolved in her stomach.

"Psy...you must ingest I think." - you can allegedly smoke it, but why bother. Some people have a smoking fixation.

"Perhaps any substance with an
Indole Ring structure like Serotonin has is allowed to cross the blood/brain barrier."
I do not understand what do you mean by this. Please elaborate." - you were discussing the blood brain barrier, as in how does it get from your blood into your brain's HT receptors? I think it can do this because either the substance itself or it's metabolates are of a very similar structure to Serotonin. I think the body mistakes it for Serotonin. In the case of Serotonin it is produced by the pituitary gland (correct me if I'm wrong) yet it still manages to get into the blood strem to travel to other organs, therefore Serotonin breaches the brain blood barrier. I guess it must have a channel to do this??? If it does then LSD and Psilo probably use the same channel, only in the opposite direction. That's my latest crap theory.

"Also, is serotonin solely produced by the brain?" - I believe only in the pituitary gland, and this gland it regulated by the hypothalmus.

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