Posted by Miguel (209.42.192.28) on August 18, 2000 at 14:22:02:
In Reply to: calcium posted by annemarie on August 17, 2000 at 16:14:18:
"But that only means that the medication inhibits nerve impulses that want to leap across the synapse through the so called calcium
channel."
Although I am not completely sure about this, I doubt that Ca++ channel blockers actually infiltrate to the nerve level.
I believe that Ca++ channel blockers work solely at the
vascular level. Where Ca++ channel blockers
elicit a vasodilatory effect in systemic circulation,
they seem to have the opposite effect in cereblal
circulation, thus allowing for the management of CH in
an inderect manner, similar to Imitrex, by
vasoconstriction of brain blood vessels.
However, I wish to learn more about the aspects
of Ca++ channels blockers and nerves. If you have
a reference to support the above quotation
please be kind enough to post it or forward it
to me via e-mail. I find this "indirect" therapy
of Ca++ channel blocking for the management of CH
quite intriguing as a matter of fact.
Miguel :)