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How does it work?

Migard tablets contain the active ingredient frovatriptan, which is a type of medicine called a serotonin (or 5HT) agonist. This type of medicine is also commonly known as a 'triptan'. It is a painkiller specifically used to relieve migraine attacks.

Although the cause of migraine attacks is not fully understood, it is thought that widening of blood vessels in the brain causes the throbbing pain of migraine headaches. Frovatriptan relieves this pain by causing the blood vessels in the brain to narrow.

Frovatriptan works by stimulating receptors called serotonin (or 5HT) receptors that are found in the brain. A natural substance called serotonin normally acts on these receptors, causing blood vessels in the brain to narrow. Frovatriptan mimics this action of serotonin by directly stimulating the serotonin receptors in the brain. This narrows the blood vessels and so relieves the pain of migraine headaches.

The dose of frovatriptan should be taken as early as possible after the migraine headache has started, though it is also effective if taken at a later stage during the migraine attack. It should not be taken during the aura, or warning phase that can occur before a migraine headache, as the safety and effectiveness of the medicine have not been established during this period, and the medicine will not prevent the headache.

What is it used for?


Relieving migraine headaches.


Warning!


This medicine should not be used to prevent migraines.


This medicine should only be used by people with a clear diagnosis of migraine from their doctor.


If the first dose of this medicine doesn't relieve your migraine headache then you should NOT take another dose for the same attack, as trials have shown that this is not effective. (You can still take Migard for your next attack.) If the first dose does initially relieve your migraine, but the headache then comes back, you can take a second dose. However, if you need a second dose because your migraine has returned, you should NOT take it within two hours of your first dose. Do not exceed the recommended dose.


Using any painkillers for headaches too often or for too long can actually make the headaches worse. If you find you need to use this medicine frequently you should consult your doctor for advice.


This medicine can cause feelings of warmth, heaviness, pressure, tightness, tingling or pain in certain parts of the body, including the chest or throat. Although sometimes very strong, these feelings usually only last a few minutes. If they continue or are particularly severe (especially chest pain), you should not take any more tablets and consult your doctor immediately.


This medicine may cause drowsiness. If affected do not drive or operate machinery.


Use with caution in


People with risk factors for coronary heart disease, such as smoking, high cholesterol levels, diabetes, obesity, or a family history of heart disease.


Men over 40 years of age.


Post-menopausal women.


Depression.


Not to be used in


Severely decreased liver function.


People who have had a heart attack.


Heart disease caused by inadequate blood flow to the heart (ischaemic heart disease), eg angina.


A severe form of angina pectoris, not caused by exertion (Prinzmetal's angina).


Narrowing of blood vessels in the extremities (peripheral vascular disease), eg problems with blood circulation in the legs or arms.


Uncontrolled or moderate to severe high blood pressure (hypertension).


People who have had a stroke.


History of small temporary strokes (transient ischaemic attacks).


A form of migraine associated with paralysis of the eye muscles (ophthalmoplegic migraine).


A form of migraine associated with temporary paralysis of one side of the body (hemiplegic migraine).


A type of migraine where there is a disturbance in brain function which initially presents with total blindness followed by dizziness, speach disturbances, ringing in the ears and double vision (basilar migraine).


Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption (Migard tablets contain lactose).


This medicine is not recommended for children and adolescents aged under 18 years, or people aged over 65 years, as there is no information available regarding its safety in these age groups.


This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.


The safety of this medicine for use during pregnancy has not been established. It is not recommended for use in pregnancy unless considered essential by your doctor. Seek medical advice from your doctor.


It is not known if this medicine passes into breast milk. It is not recommended for use during breastfeeding unless considered essential by your doctor. If you are breastfeeding and your doctor recommends you to take this medicine, you should avoid breastfeeding for 24 hours after taking the medicine, and any milk expressed during this time should be discarded. Seek further medical advice from your doctor.


Label warnings


This medication may cause drowsiness. If affected do not drive or operate machinery.


Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.


Dizziness.


Fatigue.


Headache.


Flushing.


Changes in sensation, for example pins and needles, tingling or numb sensations.


Sleepiness (somnolence).


Dry mouth.


Chest pain.


Awareness of your heartbeat (palpitations).


Feeling of tightness in the throat.


Increased sweating.


Visual disturbances.


Disturbances of the gut such as nausea, indigestion, diarrhoea, constipation, flatulence or abdominal pain.


Anxiety or agitation.


Confusion or concentration difficulties.


Mood changes.


Abnormal thinking.


Difficulty sleeping (insomnia).


Feeling weak.


Increase in blood pressure.


The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

Do not take this medicine if you have taken ergotamine or its derivatives, eg dihydroergotamine or methysergide, in the previous 24 hours. These medicines should not be taken within 24 hours of taking frovatriptan.

If your first dose of frovatriptan does not work to relieve your migraine, it is fine to take a painkiller containing aspirin, paracetamol, or a non-steroidal anti-inflammatory drug (NSAID), such as ibuprofen. However, as noted above, you should not take ergotamine, dihydroergotamine or methysergide for at least 24 hours after taking frovatriptan.

This medicine must not be taken in combination with other 5HT agonists (triptans), eg sumatriptan, zolmitriptan, rizatriptan, naratriptan, eletriptan, almotriptan.

The manufacturer states that this medicine is not recommended for people taking an MAOI antidepressant, eg phenelzine, tranylcypromine, isocarboxazid, because the combination may have an increased risk of side effects.

There may be an increased risk of a rare side effect called the serotonin syndrome if frovatriptan is taken in combination with other medicines that enhance the activity of serotonin in the central nervous system, such as the following:


selective serotonin reuptake inhibitor antidepressants (SSRIs), such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine or sertraline (fluvoxamine may also prevent the breakdown of frovatriptan in the body and could increase the risk of all its side effects)


serotonin noradrenaline reuptake inhibitors (SNRIs), such as venlafaxine or duloxetine


sibutramine


the herbal remedy St John's wort (Hypericum perforatum). This medicine is not recommended for use in combination with St John's wort.


Other medicines containing the same active ingredient

There are currently no other medicines available in the UK that contain frovatriptan as the active ingredient.


Last updated 28.05.2008

Anyone heard about or tried this??


Svenn

halftime of 26 hours as far as the rumors over here says



Svenn

Quote:



Bill  / Svenn I belive it is the same, made by Menarini,


ACTIVE PRINCIPLES: Frovatriptan  
     
TRADEMARKS:MIGARD® ALLEGRO® FROMIREX® EUMITAN® MIGRALIN® FROVEX® FORVEY® RILAMIG® AURADOL®

THERAPEUTIC AREAS: Antimigraine      

Multimedia File Viewing and Clickable Links are available for Registered Members only!!  You need to or

About effectiveness ......  no Idia.....  but asked for a study, wonder
what I will get, if at all......... and if any info about CH and the above Triptan...

Michael

I think it was Helen who said that it's great for long flights.

I've taken Frova.  My doctor gave me an 8 day sample pack when I was in high cycle.  I took it in the am before work .  I also started verapamil the same day I started Frova.   Like Carrie, I used Frova as prevent-  I didn't notice any particularly bad side effects- seemed milder to me than the trex - 

Frova worked great for me.  I could count on being pain free all day and into the night.  I was sad when my supply was gone, but by that time verap kicked in well enough so my HA were pretty much prevented anyways.

Next cycle- its what I am asking for to get me over the hump- 


kelly

Wendy!  Hello!!  Long time no see!

Are you doing well?  Sorry to hear about the funeral...

I have gotten a max of 10-12 hours out of the Frova for CH, which is pretty good for me!  I also find that if I use it too often, it doesn't work as well - I start to notice it and then back off on using it for awhile.  When I was in England visiting Helen, I took the Frova most days, but only got a few breakthrough hits, which was lovely!

Good to see you around here!

Hugz,
Carrie/Lizzie2

pubgirl wrote on Aug 28^th, 2008 at 5:24pm:


I was there in September of 2006.  Would like to come back soon, if Helen will have me!   I feel badly - been away from OUCH UK for a long time too.  I got a nerve stimulator, too - like Mike and the rest of the gang, but I also have a supraorbital lead.  It's infected though and I'm having more surgery on 9 Sept. 

I absolutely fell in love with England when I was there!  I'd literally move there tomorrow if my boyfriend, Jason, would come too!  He and I are moving in together on 13 Sept to a new place on the Pennsylvania/Delaware state borders.  I'm leaving my beloved Narberth!

Anyway - sorry to hijack the thread!  I've missed ya!!

Hugz,
Carrie