Monika wrote on Jan 12th, 2010 at 2:29am:Since we are on this topic,
I really need an answer to this one... I'm here cause my brother is experiencing the clusterheadaches and he's been taking imitrex (sumatriptan) for almost a week.. like 2 a day.. he is going to start LSD but since he got an attack today he took sumatriptan and now I dont think he can take LSD since I've been reading that it usually stops the help of LSD..
He's gettin g really desperate and im curiuos... how long should he wait before he takes the LSD now? 24 hours since he took imitrex? or what?
Also, if he starts doing LSD, if by some chance after some time of taking lsd my brother would take imitrex.. would that mess up the progress with lsd?
This is the hardest part about dosing on any of the hallucinogens. Meaning, taking a couple of hits for the detox to take place. You'll need to detox from triptans for the most effectiveness of the LSD.
Here's a good old copy and past job from Clusterbusters. I suggest you save and read everything on that site.
4.1.2 Possible inhibitorsThere are some medications which may interfere with psilocybin (and LSD):
* anti-convulsants or anti-epileptic medications such as Neurontin(gabapentin) and Topamax(topiramate). The exact mechanism by which topiramate works, for example, is still unknown, so it is impossible to even guess whether or not it will interfere with psilocybin.
* medications which are either synthetic analogs of certain hormones or which regulate hormone production: Prednisone and Synthroid, for example. There is no direct evidence to suggest that these drugs will interact with psilocybin, but hormones have a very complex and inter-related effect on numerous body systems. We have seen a few reports suggesting that thyroid levels play a part in cluster headaches
* tranquilizers and mood-altering medications such as Xanax, Valium, Prozac and Wellbutrin.
* Ondansetron (Zofran) and Compazine (prochlorperazine)
* * Imitrex (and associated triptans):
Based upon many reports, triptans are one of the most likely medications to block the clusterbusting effects of psychedelics. In our opinion, they should be avoided both before, during and after, beginning psychedelic treatments for clusters.
1. sumatriptan (Imitrex®, Imigran®) injections
2. sumatriptan (Imitrex®, Imigran®) tablets
3. zolmitriptan (Zomig®) tablets
4. sumatriptan (Imitrex®, Imigran®) nasal spray
5. naratriptan (Amerge®, Naramig®) tablets
6. rizatriptan (Maxalt®) tablets and rizatriptan orally dissolvable (Maxalt-MLT®) tablets
7. zolmitriptan orally dissolvable (Zomig-ZMT®) tablets
8. almotriptan (Axert®) tablets
9. frovatriptan (Frova®) tablets
10. eletriptan (Relpax®) tablets
Related Articles, Links
Headache. 2004 Jul;44(7):713-8.
Subcutaneous sumatriptan induces changes in frequency pattern in cluster headache patients.
Rossi P, Lorenzo GD, Formisano R, Buzzi MG.
Objectives.-To document the relationship between the use of subcutaneous (SQ) sumatriptan (sum) and a change in frequency pattern of cluster headache (CH) in six patients. To discuss the clinical and pathophysiological implications of this observation in the context of available literature. Background.-Treatment with SQ sum may cause an increase in attack frequency of CH but data from literature are scant and controversial. Methods.-Six CH sum-naive patients (three episodic and three chronic according to the International Headache Society (IHS) criteria) are described. Results.-All six patients had very fast relief from pain and accompanying symptoms from the drug but they developed an increase in attack frequency soon after using SQ sum. In all patients, the CH returned to its usual frequency within a few days after SQ sum was withdrawn or replaced with other drugs. Five patients were not taking any prophylactic treatment and SQ sum was the only drug prescribed to treat their headache. Conclusions.-Physicians should recognize the possibility that treatment of CH with SQ sum may be associated with an increased frequency of headache attacks.
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