Hey Shooky,

Sorry to be so slow in responding...  Just got home last night from a two-week fishing trip to Alaska.

I know what you're going through.  Although it appears you're doing everything right with respect to the anti-inflammatory regimen supplements you might try increasing the vitamin D3 and Diphenhydramine doses as you'll see below. 

A little over a week ago I got full of myself and decided to pull one of my 25(OH)D burn down tests by stopping vitamin D3 to see how long it would take to get hit.  I'm a chronic CHer and this usually takes a week before I get hit...  This time it was different... I got hit with a Kip-4 two nights later.

The CH hit came at night while sleeping, so I took a 50,000 IU sublingual loading dose by popping the softgels between my back teeth and swirled the contents under my tongue and kept them there until completely dissolved.  15 minutes later the pain was gone so I went back to sleep with no further hits that night.

The next day I took 25,000 IU of vitamin D3 along and the rest of the cofactors with the evening meal then chewed up another 25,000 IU of vitamin D3 at bed time...  It didn't work.  I got hit with another Kip-4 around 1 am so chewed up another 25,000 IU of vitamin D3.  The pain cleared in five minutes so I went back to bed and slept pain free the rest of the night.

I repeated the dosing scheme the following night and got whacked again at 1 am.  At that point the light came on... an allergic reaction to something... and I wasn't drinking enough water so I took 50 mg of Diphenhydramine, downed two glasses of water, went back to bed and slept pain free the rest of the night.

By last Tuesday night I was taking 50,000 IU/day vitamin D3 (25,000 IU with the evening meal and 25,000 IU sublingual at bed time) and 100 mg of Diphenhydramine (50 mg with the evening meal, another 50 mg at bed time).  I also drank several glasses of water during the day and slept downstairs upright in a recliner.  I got hit that night at 1 am as usual, but it was so mild I didn't get up and went right back to sleep.  Same doses Wednesday night and another minor hit while sleeping.

I took the cofactors Thursday morning with breakfast but no vitamin D3 or Benadryl.  I got home around 8 PM last night and and was in bed by 9 PM.  I slept like a baby pain free for 12 hours with one obligatory pit stop around 2 am to drain the swamp...  I even took a one hour combat nap after lunch today... that's usually a sure invitation for the CH beast to jump ugly...  but it didn't..  I'm back on my maintenance dose of 10,000 IU/day vitamin D3 plus the cofactors and will keep you posted if anything comes up.

So, as a recap, I'd up the Diphenhydramine (Benadryl) dose to 50 mg with the evening meal and another 50 mg at bed time.  Most dosing guides for Diphenhydramine list the adult do not exceed dose at 300 mg/24 hours.  I'd also drink plenty of water...  Shoot for at least 2 liters a day.

Bump the vitmain D3 up to 50,000 IU/day for a few days taking 25,000 IU and the rest of the cofactors with the evening mean and the last 25,000 IU sublingual at bed time. 

If that doesn't result in a favorable response after two days, sleep in a different room.  I know this sounds crazy... like my elevator doesn't go all the way to the top...  but it could be an allergen associated with the bedding or air conditioning...   

Mold spores can easily trigger an allergic response so check the filter in the air handler or window mounted air conditioner.   There's usually a drip pan under most refrigerators.  Spray it with a 50:50 mix of Clorox and water.

Finally, there's good old vitamin C.  I take a 1000 mg tablet every 2 to 3 hours for a total of 6000 mg/day if I suspect mold spores.

Hope all this helps.

Take care and please keep us posted.

V/R, Batch