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Anti-Inflammatory Vitamin D3 Regimen and Survey (Read 195796 times)
shokaveli
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #850 - Aug 14th, 2019 at 5:05pm
 
Batch,

Thanks for the info and I read around a bit before going in and saw that you recommended the Bio-Tech D3 instead so I went with that one.† Very interested as well on your response to Pattik above.

Lastly, I posted about this on a different thread but was hoping to get your input on it regarding O2 therapy.† In short, I tried O2 and the HV method (@ 15lpm then upped to 25lpm) for the first time last night for 10-12 minutes and my KP4 CH did not seem to go away fully although it seemed to get better.† I stopped the O2 and the pain started to get worse but I waited for about 5 minutes and it just suddenly aborted completely without a shadow.† I'm wondering if you have ever seen this before and if you think the O2 was a contributing factor for the abortion or if it was just some (super) weird coincidence as my CH's NEVER go away just like that without meds (and even those take at least 30 mins to kick in). TIA!

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« Last Edit: Aug 14th, 2019 at 5:06pm by shokaveli »  
 
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Batch
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #851 - Aug 15th, 2019 at 10:09am
 
Shockaveli,

Interesting topic - daily vs weekly vitamin D3 dosing.  This has also been a hot topic at the Vitamin D3 Workshops.  If you go over my posts here at clusterbusters and over at clusterheadaches.com you'll see that I've been an advocate of daily vitamin D3 dosing from the very beginning starting in December of 2010.

I've studied vitamin D3 pharmacokinetics (what the body does to vitamin D3) and its pharmacodyamics (what vitamin D3 does to the body) extensively so know the enzymes needed to hydroxylate vitamin D3 to its genetically active metabolite 1,25(OH)2D3 are expressed at the cellular level throughout the body.  This was proof enough to say daily dosing was the best. 

1,25(OH)2D3 is the vitamin D3 metabolite that triggers genetic expression of peptides that do the autocrine and paracrine signaling that down-regulates the expression of calcitonin gene-related peptide (CGRP) and substance P (SP) and this helps prevent our CH.

That said, I've found weekly dosing with the Bio-Tech D3-50 is just as effective in preventing my CH. My labs for 25(OH)2D3, calcium and PTH confirm that weekly dosing with the Bio-Tech D3-50 water soluble vitamin D3 is very effective in maintaining my 25(OH)D serum concentration at 150 Ī2 ng/mL.  That indicates a bioequvalence two to three times greater than the oil-based liquid softgel vitamin D3 formulations at the same dose.

In addition, data from the online survey of CHers taking this regimen indicate for the first six months of 2019, 90% of CHers reporting in this time frame have experienced a significant reduction in the frequency of their CH.  I suspect this increase in efficacy above the year-over-year average of 82% is due in part to some CHers taking the Bio-Tech D3-50.

For now, I think its safe to say the jury is still out on which method of dosing is best.  We need more data. 

Take care,

V/R, Batch
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #852 - Aug 15th, 2019 at 8:02pm
 
Shockaveli,

Regarding your strange CH pattern after using oxygen therapy.  If you've been on the accelerated vitamin D3 loading schedule for even one day... I'll opine your CH pattern change was due to the vitamin D3... and I'll double down if you were taking the Bio-Tech D3-50.

Take care,
V/R, Batch
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #853 - Aug 18th, 2019 at 7:12pm
 
Batch,

So I now have been getting consistent success with the O2, aborts it every time.  So this last time I used it around 15 min in @ 15 lpm, I started to feel some intense tingling of my arms and fingers and slight numbing.  Luckily I stopped and the tingling went away.  Have you ever experienced something similar to that?  I have only been getting on the O2 for 15-20 minutes at a time maybe 1-2 times a day.
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Mike NZ
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #854 - Aug 19th, 2019 at 4:15am
 
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Quote:
When you're overbreathing, you might not be aware you're breathing fast and deep. But you'll likely be aware of the other symptoms, including:
Feeling lightheaded, dizzy, weak, or not able to think straight
Feeling as if you can't catch your breath
Chest pain or fast and pounding heartbeat
Belching or bloating
Dry mouth
Muscle spasms in the hands and feet
Numbness and tingling in the arms or around the mouth
Problems sleeping


Perfectly normal symptoms when you hyperventilate.

The symptoms should go away once you stop, as you've experienced, when the CH is also gone.

If you have any questions, do consult your medical doctor.
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Batch
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #855 - Aug 19th, 2019 at 11:04am
 
Hey Shokaveli,

Good question and Mike's response is spot on.† The tingling and numbness sensations you experienced during oxygen therapy is called paresthesia.† It's a very normal side effect during oxygen therapy at flow rates that support hyperventilation.† It's not only harmless as it dissipates rapidly when returning to normal respiration rages, it's also your friend as it indicates you're using oxygen therapy effectively as a CH abortive.†

During hyperventilation, we blow off CO2 faster than our bodies generate it through normal metabolism.† †This lowers arterial CO2 content causing an upward shift in arterial pH towards the alkaline side of neutral.† This is condition is called respiratory alkalosis, a medical term you may have heard in the movie The Andromeda Strain.† Respiratory alkalosis has two beneficial side effects where the elevated pH causes blood hemoglobin to have a greater affinity for oxygen and it also triggers vasoconstriction.†

The tingling sensation, paresthesia, is caused by vasoconstriction of the capillaries and microvasculature in the dermis and subcutaneous layers of your skin.† The same thing is happening in the trigeminovascular complex.† This is part of the CH abortive process as during a CH, vasculature in the trigeminovascular system dilates rapidly.

In addition, the hyper-oxygenated blood flow to the brain made possible by the elevated arterial pH, causes a more rapid breakdown of the neruoactive peptides, Calcitonin Gene-Related Peptide (CGRP) and Substance P (SP) in the trigeminal ganglia.† As CGRP and SP are responsible for the neurogenic inflammation and pain we know as CH, breaking them down rapidly is also part of the CH abort mechanism.

So, to my way of thinking, paresthesia during oxygen therapy as a CH abortive is a very good sign.† If you're not experiencing it, you're not doing it right.

I'm still looking for the answer to my question, did oxygen therapy become more effective after starting the vitamin D3?

Take care and please keep us posted.

V/R, Batch
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« Last Edit: Aug 19th, 2019 at 11:08am by Batch »  

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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #856 - Aug 21st, 2020 at 11:52pm
 
For the fish oil, is the total amount in mg more important or is there a specific amount of omega-3 (EPA & DHA), I should be looking for?†

For example, in Batch's original post, he recommends 1000-2400 mg of fish oil per day with a minimum of EPA 360mg and DHA 240mg.  Is it important to reach the 1000-2400 mg threshold or just the EPA and DHA amount?
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« Last Edit: Aug 21st, 2020 at 11:56pm by slacker032 »  
 
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Batch
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #857 - Aug 24th, 2020 at 5:39pm
 
The EPA DHA amount is the minimum target.
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #858 - Aug 24th, 2020 at 6:11pm
 
Gotcha.  Thanks Batch.
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #859 - Dec 5th, 2020 at 9:13pm
 
After 10 years of suffering this regimen has saved me. I stead of 6 weeks I only have 1 week. Itís extraordinary. Thank you all for this.
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #860 - Dec 8th, 2020 at 12:53pm
 
Hey Grandchester,

Thanks for the update.† Glad the anti-inflammatory regimen is working for you.† Have you had a recent lab test of your serum 25(OH)D3?† If so, please take the online survey for CHers taking this regimen.

To start this survey, click on the following link:

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Take care and please keep us posted.

V/R, Batch
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #861 - Jan 5th, 2021 at 6:07am
 
Hi all and Happy New Year.

Not been on for a while but glad to report the D3 regimen is still working well for me and still very much pain free. Apart from just getting over shingles on my head which attacked the Trigeminal nerve so you can imagine how much fun that was, still got the sensitive scalp thing going on 3 weeks later!!

Anyway, I have a question about Magnesium supplements.

Been looking for one that is kinder on the digestive system and the general consensus is Magnesium Glycinate or Biglycinate. Now the question I have is about dosing. Before I was just taking 400mg a day of the Now Magnesium Caps and not thinking anything of it but looking at the Glycinates they all mention 'elemental magnesium'. So for example a 500mg Glycinate capsule may contain 100mg of elemental magnesium, so does that mean I still take one cap or do I now have to take 4 of those to get the 400mg daily dose, confused?
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #862 - Jan 5th, 2021 at 11:59am
 
Hi Chuffy,

I'm happy to hear you are still doing well with the D3 regimen. I have been using "Doctor's Best" brand chelated magnesium lysinate glycinate for a few years with good results. The citrate was a little tough on my digestive track. My bottle says the tablets are 100 mg each, and that is the elemental amount after 1000 mg.
The "elemental" amount is the amount you need to use for your regimen. Supposedly, the chelated version of the mineral allows it to be taken with or without food, since it is bound to amino acids. I take it with food anyway.

I was taking 400 mg (four 100 mg tabs) /day split between 2 or 3 meals. I recently reduced it to 3 tabs/day, since that dosage has been adequate for me now.

I hope that clears things a little. So the "elemental" amount is what you're after for your dosage.

Take care,
Patti
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #863 - Jan 5th, 2021 at 12:21pm
 
Hi Patti

That's great , thanks for the help/explanation
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #864 - Jan 5th, 2021 at 7:40pm
 
Hey Chuffy,

Glad to hear you're still CH pain free, but I wish I'd known about your shingles.  I had them in 2016.  They started as a stiff neck and slight tingling sensation across my upper chest.  I was in Pelican Alaska salmon fishing and only had enough vitamin D3 for 10,000 IU/day with me. (Very poor planning that's never happened again on travel). 

The sensations continued to grow in intensity over the last four days of the fishing trip.  By the time I got off the plane in Seattle, the pain had escalated to the point the slightest movement of my head sent what felt like 110 Volts AC shock across my upper chest.

As soon as I got home, I took 100,000 IU of vitamin D3 and crashed.  Less than 6 hours later when I woke up, the neck pain was completely gone and there was no tingling across my upper chest.  I took 50,000 IU/day of vitamin D3 for the next two days.  There was no post herpetic neuralgia and there was no outbreak of the classic shingles rash only a very slight numbness across the area innervated by the third and fourth Cervical supraclavicular sensory nerve.

Bottom line, a long time dose of 10,000 IU/day vitamin D3 is not sufficient to stop the shingles varicella-zoster virus infection spreading from the dorsal root ganglia along the sensory nerve to the area of the body it innervates.  That said, a large bolus dose of 50,000 to 200,000 IU of vitamin D3 can stop the varicella-zoster virus dead in its tracks.

What we've learned since the COVID-19 studies have started reporting out is 50 mg/day zinc, 800 to 1000 mg/day Quercetin, 3 to 6 grams/day vitamin C and Invermectin can also kill virus including the SARS-CoV-2 virus.

Howz the COVI-19 lockdown affecting you in the UK?  Things are as screwed up as Hogan's goat around here and there's no light at the end of the tunnel. 

The Senate run off elections in Georgia look like deja vous all over again with fraudulent signature validation, voter fraud and defective Dominion voting machines that just happened to break down in Republican districts - but not in the socialists strongholds.   The only question now is how many votes will be added to ensure the socialist win with convincing numbers.

Even if the mRNA COVID-19 vaccines are effective, we all will still be required wear masks.  What the BIG Pharma and BIG Government pseudo experts are not telling people is the mRMA vaccines require a healthy immune system to work effectively.

The only real good news is if you're taking at least 10,000 IU/day vitamin D3, the probability of coming down with COVID-19 is very low.

Take care and please keep us posted.

V/R, Batch
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #865 - Jan 6th, 2021 at 1:00pm
 
It's plenty bad enough to mislead people here with your misguided and unproven assertions about Covid;  but do you really need to lie about American elections to an overseas audience?  How does that help CH sufferers?
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #866 - Jan 7th, 2021 at 1:34am
 
COVID-19 treated by Vitamin D - studies, reports, videos/


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As of Jan 6 had:† 34 trials,† 4 trial results,† 10 meta-analyses and reviews,† †39 observations,† †22 recommendations,† †41 associations,† 82 speculations,† 34 videos.

Traveller, If your lips get tired, you can always watch the following video by Professor Roger Seheult, MD.† He explains the important role Vitamin D may have in the prevention and treatment of COVID-19.† Note:† He is required by a law written by the BIG Pharmas to use the word "may."† Otherwise he would be making a claim of efficacy that's reserved for the exclusive use in explaining patented Rx.

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The attached FLCCC MATH+ Hospital Treatment Protocol for COVID-19 treatment protocol calls for an oral dose of 480,000 IU of vitamin D3 for COVID-19 patients upon admission to the ER and 90,000 IU/day vitamin D3 for five more days if serum 25(OH)D3 is less than 20 ng/mL.

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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #867 - Jan 7th, 2021 at 5:10am
 
Batch wrote on Jan 7th, 2021 at 1:34am:
Regarding the theft of elections by globalist, socialists and communists...

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Very interesting,† certainly,† but perhaps more at home on the General Posts board rather than here amongst Medications, Treatments and Therapies.
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #868 - Jan 7th, 2021 at 10:41am
 
AussieBrian wrote on Jan 7th, 2021 at 5:10am:
Very interesting,† certainly,† but perhaps more at home on the General Posts board rather than here amongst Medications, Treatments and Therapies.


Perhaps you have forgotten who the original poster is on this thread? Perhaps you should ignore this thread in the future if it offends you.
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #869 - Jan 7th, 2021 at 12:54pm
 
Or perhaps the poster in question could keep his political views (and lies) to himself, and concentrate on trying to help suffering CHers.
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #870 - Jan 7th, 2021 at 4:44pm
 
Folks, the general topic section is there for a reason and it sure could use the traffic.
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #871 - Jan 8th, 2021 at 5:32am
 
Thanks Batch, I did increase my D3 intake during the shingles outbreak and am sure it helped.

As far as the Magnesium goes, do I actually still have to take all of the 400mg a day if I'm pain free or will 100mg or 200mg be ok, or is it about keeping the regimen balanced, I know it's harder to judge what's what being episodic?
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #872 - Jan 9th, 2021 at 12:19pm
 
Hey Chuffy,

Thanks for the update and great question.† The short answer is yes.† As long as we're taking vitamin D3 to prevent our CH, we also need to be taking the vitamin D3 cofactors and that includes magnesium.

The longer answer is magnesium as well as zinc are consumed in the enzymatic processes that hydroxylate vitamin D3, (add† a Hydroxyl group [OH] to the vitamin D3 molecule's 25th position to form 25(OH)D3 and 1st position to form its genetically active metabolite 1,25(OH)2D3).† The following chart illustrates the metabolic pathway vitamin D3 takes to arrive at it's goal of initiating genetic expression.† The genes annotated in blue are responsible for expressing the enzymes needed along the way.

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There's another enzyme, RNA polymerase that's essential in producing the messenger RNA (mRNA) during genetic expression that down-regulates the primary neuropeptides, CGRP, SP, VIP and PACAP, all of which play roles in the pathogenesis of CH.†It's the down-regulation (reduction) of these neuropeptides by vitamin D3 that helps prevent our CH.

The following chart illustrates how a strand of mRNA is transcribed (copied) from the DNA helix then passed from the cell nucleus into the cytoplasm where it is taken up by ribosomes.†

Ribosomes are sub cellular chemical factories that read the recipe or blueprint encoded in the mRNA then draw in amino acids from the cytoplasm to produce proteins.† These proteins then act as autocrine or paracrine signalling agents to change cell functions to replicate, differentiate. up- or down-regulate genetic products or they signal apoptosis, programmed cell death.

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In short, if this genetic expression doesn't take place due to a lack of magnesium and zinc, there's a greatly reduced CH preventative effect while taking vitamin D3.

Another very important example of genetic expression involves the COVID-19 vaccines.† These vaccines are mRNA segments that have been isolated and reproduced in a laboratory. They contain the genetic code, recipe/blueprint for the glycoprotein spike from the SARS-CoV-2 virus.† Ribosomes read this mRNA segment to produce the glycoprotein spike shown in the small circle, but not the entire SARS-CoV-2 virus illustrated in the following graphic.

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This is where things get really interesting.† In order for this mRNA vaccine to be effective in preventing COVID-19, our innate immune system, our first line of defense against invading antigens like virus, swings into action.† This is where macrophages and neutrophils (special white blood cells that include natural killer cells) identify this glycoprotein spike as a non-self invading antigen or foe, then consume/eat the spike.† This identification, friend or foe (IFF) capability requires the vitamin D3 metabolite 1,25(OH)2D3.† Without vitamin D3 the natural killer cells cannot tell the difference between self and non-self so lack this essential IFF capability.

This process signals our adaptive immune system's B-Cells and T-Cells to swing into action.† These two immune cells are capable of developing antigen-specific "memory" that confers immunological protection.† B-Cells express antibodies uniquely targeted at a specific antigen, in this case the glycoprotein spike.† They also alter their own DNA to retain the genetic code required to express these same antibodies at a later date if the glycoprotein spike presents again.† Hence we have long term immunity that can last many years.†

Once the antibodies produced by B-Cells start attaching to the glycoprotein spike, killer T-Cells are attracted to these antibodies and actually eat the glycoprotein spike and cells infected with this spike reducing them to harmless waste products that are eliminated from the cell.† These processes also require the vitamin D3 metabolite, 1,25(OH)2D3.

There's a disturbing aspect of immune system activity that many emergency medicine physicians did not understand until the COVID-19 pandemic broke out. The initial battle waged against invading antigens by the innate immune system cells causes these cells to reproduce (replicate) rapidly and release cytokines that trigger inflammation.† The natural killer cells and killer T-Cells continue to eat these virus with no problem.†

However, the neutrophils and B-Cells die once they've eaten the virus and form pus which accumulates in the tissues lining the nasal passages and cells lining the lung's alveoli.† Without vitamin D3, the immune system becomes dysregulated with uncontrolled immune cell replication and release of cytokines in what is called a "cytokine storm."† †The buildup of dead cells and pus inhibits the uptake of adequate oxygen in the lungs causing hypoxia.† This is where COVID-19 patients require supplemental oxygen and if the cytokine storm continues, intubation.† At that point, survival rates drop rapidly.

Bottom line, if you intend to get the COVID-19 vaccine, your immune system will need a lot of vitamin D3 to make this mRNA vaccine effective.†

This begs the question, how much vitamin D3 is needed?† Fortunately there have been hundreds of studies of COVID-19 and vitamin D3 looking at this problem.† The following graphic, from one such peer reviewed study, gives us an obvious clue how much vitamin D3 we need to keep from dying from COVID-19.† The answer is enough vitamin D3 to elevate 25(OH)D3 serum concentration > 40 ng/mL or a minimum of 5,000 IU/day vitamin D3 for at least three weeks.

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The following chart illustrates the time course 25(OH)D3 serum concentration response to various doses of vitamin D3.† As you can see, it takes three weeks at a vitamin D3 dose of 5,000 IU/day for serum 25(OH)D3 to reach 40 ng/mL and three to four months to reach 60 ng/mL. The 10,000 IU/day vitamin D3 we take to prevent CH is even better.

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There are other peer reviewed studies that conclude the higher the 25(OH)D3 serum concentration above 40 ng/mL, the more favorable the outcome from COVID-19 and at a high enough serum concentration, COVID-19 will likely be asymptomatic when infected by the SARS-CoV-2 virus.† †

This is where CHers who have been taking the anti-inflammatory regimen with at least 10,000 IU/day vitamin D3 or 50,000 IU/week with the Bio-Tech D3-50 for more than a month or who started this regimen with the 12-Day accelerated vitamin D3 loading schedule, can breath a sigh of relief.† †Even if they can't obtain the COVID-19 mRNA vaccine any time soon, their 25(OH)D3 serum concentration has boosted their immune system functions to help prevent COVID-19 and the deadly cytokine storm.† Their mean 25(OH)D3 serum concentration is illustrated in the following normal distribution chart from the online survey over 350 CHers have taken since December of 2011 at an average dose of 10,000 IU/day plus the cofactors.

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The other thing people need to understand is even if they don't have CH and they've not been taking vitamin D3, their 25(OH)D3 serum concentration will likely fall under the following normal distribution chart of baseline 25(OH)D3 lab tests CHers took prior to starting the anti-inflammatory regimen.

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As you can see, nearly 95% of these CHers had a 25(OH)D3 serum concentration less than 40 ng/mL and over 60% were less than 30 ng/mL.† The 50% at and below 24 ng/mL would have been in deep kimchi had they been infected with the SARS-CoV-2 virus.† †

It doesn't take rocket science to realize everyone, including CHers, their families and friends all need to start taking at least 10,000 IU/day along with the rest of the vitamin D3 cofactors ASAP.† Kids under 100 lbs (45 Kg) need to take between 50 to 100 IU of vitamin D3 per pound of body weight per day (110 to 220 IU of vitamin D3 per Kg of body weight per day) to attain a 25(OH)D3 serum concentration of 80 ng/mL (200 nmol/L).

As a side note, this regimen is so safe, I've had my entire family and many close friends taking it since 2011.† That includes four grand babies my daughter and niece delivered flawlessly after very normal pregnancies.† These grand babies were bathed in maternal vitamin D3 from conception through breastfeeding.† As a result, they have T-Rex immune systems.† They don't get sick.

My earlier post of 6 January provided the following vitamindwiki link.

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It lists 34 trials,† 4 trial results,† 10 meta-analyses and reviews,† †39 observations,† †22 recommendations,† †41 associations,† 82 speculations and 34 videos about using vitamin D3 as an effective intervention for COVID-19.† You be the judge.

So there you have it.† The long answer.

Take care and please keep us posted.

V/R, Batch
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #873 - Jan 10th, 2021 at 5:03pm
 
Hello Batch, the above post is nothing short of intriguing and again, as I have said before, thank-you SIR.

I have shared this post to the Cluster Headache Facebook channel so others may benefit from the insightful post.

As I move through this, I have a question if I may, please.

In respect of consumption of the cofactors. Is the fact that cofactors are required for the actions of vitamin D evidence that cofactors are used up in those enzymatic process or just that they need to be present in order for the reaction to occur?
For example, a magnet is required for an electric motor to function, however the magnet is not used up each time the motor moves - it is just required to be present for the system to work.
In other words, if the above is correct and the cofactors just need to be present in order for hydroxylation of D3 to occur, and the cofactors are still present before and after and not consumed in the enzymatic process, why is it important for us to keep supplementing with the cofactors?

Also, for years I have followed your D3 regimen, with great success - I've encouraged others do to the same. It's really rewarding to have now started to understand the science behind it, so much so - I'd like to commit to some formal study. Would you be able to give some advice as to where and how you started your educative journey and what you might recommend for a newcomer to begin their learning journey? Thanks again for all you do and for your contributions Batch!
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Re: Anti-Inflammatory Vitamin D3 Regimen and Survey
Reply #874 - Jan 11th, 2021 at 8:57pm
 
Thinker,

Thank you for the update and kind words.† Thank you also for sharing this important information among CHers on FB.

My understanding of the role of enzymes with respect to preventing cluster headache is still a work in progress.† As my undergraduate degree was in Chemistry with plenty of biochemistry, what I learned is enzymes function as a catalyst in biochemical reactions, but do not take part in that biochemical reaction once started.†

The catalytic process enables a chemical reaction to occur and take place at higher rates than if it were not present.† Virtually every biochemical reaction in the human physiology is initiated with enzymes.† And here's the kicker, the enzymes are produced (expressed) through the process of genetic expression by ribosomes.

A simple analogy and example of a catalyst is a nudge given to a basketball at the top of a stairway.† Once placed in motion by the catalytic nudge, it is no longer involved as the ball bounces down the stairway consuming potential energy by converting it to kinetic energy until it reaches the floor at the bottom of the stairway at a lower potential energy state where it stops bouncing.† In the case of an enzyme initiated biochemical reaction, the energy needed to initiate that reaction comes from the catalyst as it is broken down and thus consumed in the process.

These chemical reactions start at a relatively high potential energy state, proceed as potential energy is converted to kinetic energy and consumed, concluding at a lower potential energy state where the chemical reaction ends.† Accordingly, these processes proceed in accordance with the first and second laws of thermodynamics.†

As enzymes are broken down and consumed, the short answer to your question is the cofactors or co-nutrients as some call them, are consumed in the process of producing these enzymes so must be replaced.† The following link to the GrassrootsHealth Nutrient Research Institute provides an excellent discussion of the roles of co-nutrients along the vitamin D3 metabolic pathway to and including the vitamin D3 role in genetic expression.

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As you'll see from the graphics discussed in this link, the 25(OH)D3 response to dose of vitamin D3 is increased by each of these co-nutrients.† When the individual increases for each of these cofactors/co-nutrients are taken together, there's a synergistic effect where the overall 25(OH)D3 response is significant higher.

Results from the survey of CHers taking the anti-inflammatory regimen also indicate the sought after physiological response to this regimen, a reduction in the frequency of CH or its complete cessation are also increased significantly due to the cofactors/co-nutrients.

There is one small problem with the GrassrootsHealth discussion on co-nutrients.† The paragraph on vitamin A may leave readers with the wrong impression that vitamin A should be avoided as it competes with vitamin D3 for available vitamin D receptors (VDR) at the cell membrane and at the DNA level within the cell nucleus.† While it is true that too much vitamin A (retinol or retinyl palmate) competes for VDR, a small amount of vitamin A is essential in the formation of the 1,25(OH)2D3-Retinoic Acid Dimer that initiates the first phase of genetic expression transcription.† Without this small amount of vitamin, A, the rate and magnitude of vitamin D3 enabled genetic expression is significantly reduced. This process is illustrated in the following graphic.

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I say this as taking the 450 mcg/day of vitamin A (retinol) illustrated in the Supplement Facts label on the Kirkland Adult 50+ Mature Multi after 10 years and thousands of CHers starting this regimen is just about right.

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As to where to start your studies of vitamin D3, I would do an Internet search using the following search terms [Vitamin D AND Heaney].† That should result in several dayís worth of reading.† Then add [AND Am J Clin Nutr] to the search query and you'll pick up Dr. Heaney's studies published in the American Journal of Clinical Nutrition.† That's worth another day or two.†

Dr. Robert P Heaney, MD, Professor of Medicine, Creighton University was the first vitamin D3 expert I contacted in early 2011, after I discovered vitamin D3 and its cofactors stopped my cluster headaches after the second dose of 10,000 IU/day vitamin D3.† †

He was kind enough to mentor my studies of vitamin D3 pharmacokinetics and pharmacodynamics. He gave the initial version of my anti-inflammatory regimen treatment protocol a thumbs up and he also gave me pointers on developing the study protocol used in the online survey of CHers taking this regimen.† He was a giant in the field of vitamin D3 research.† We lost Robert to brain cancer in 2016.

With that under your belt, go to the vitaminDwiki.com website run by my dear friend Henry Lahore.† Henry created and maintains this website and has web crawlers searching all things vitamin D3 7/24, 360 days a year.† You'll never read everything on this website, but you will find my web page on preventing cluster headache with vitamin D3 that Henry maintains for me.† Henry has compiled the most extensive list of studies, papers and videos on the use of vitamin D3 as an intervention and preventative for COVID-19 at the following link.†

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ideos

Your next website is grassrootshealth.com created and run by another dear friend, Carol Baggerly.† I suggest you become a member so you get the frequent updates from Carol by email.† If you're like me, you'll peruse both VitaminDWiki and GrassrootsHealth websites on a near daily basis.† There's almost always something new.

Hope this helps.

Take care and please keep us posted,

V/R, Batch
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