To All,
Sorry to be so slow. I spent the last 36 hours trying to get my email send function back online and have yet to achieve success. I can receive emails but not send. Attempts to reset futile. Nobody home at AOL due to the lock-down and I suspect I've had malicious intrusion in my account at the host. On top of that, the bird dogs on my router firewall and Macbook Pro have also alerted a few times over the last week so don't be surprised if I drop off the net completely.
Everything I've read over the last two months leads me to conclude susceptibility to COVID-19 infection is no different than cluster and migraine headache. It's due to deficiencies in vitamin D3 and very likely zinc and vitamin C.
On to the latest. The following list of supplements represent the best available information I can find on nutritional preventatives we can take on top of the items put out by the CDC to prepare us for exposure to the SARS-CoV-2 virus. This list of supplements comes from Dr. Ron Hunninghake, MD, Chief Medical Officer, Riordan Clinic, Wichita, Kansas. He suggests taking them as an immune-boosting strategy to his staff and patients in the Riordan Clinic system. See. Multimedia File Viewing and Clickable Links are available for Registered Members only!! You need to

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1.
Vitamin C: 1,000-2,000 mg, 3-4 times a day (to bowel tolerance)
2.
Vitamin D3/K2: 1,000 IU, twice daily
3.
Vitamin A: 10,000 IU, per day
4.
Zinc Picolinate: 30 mg, twice daily with food
5.
Selenium: 200 mcg, 1-2x daily with food
(Note: please implement BEFORE getting ill if possible.)
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For CHers presently taking the anti-inflammatory regimen shown above, all you really need to do is double the Kirkland Adult 50+ Mature Multi by taking one tablet in the morning with breakfast and the second with the evening meal and you've got everything in the above list covered with the exception of the vitamin C.
I ordered a 1 Kg bag of powdered vitamin C from amazon in early February and use it to refill the Fruit Fresh shaker I keep on the kitchen counter. For a family of four, a 1 Kg bag of powdered vitamin C is a little less than a 3-month supply at 3 grams/day per person.
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I put a dash (1/4 teaspoon = 1 gram) of vitamin C in juice or water at least 3 times a day. (Be sure to stir it for a while as it is slow dissolving). For happy hour, I add it to a screwdriver, bloody marry or margarita and my favorite, a Tequila Sunrise. Joyce does an Emerald Lagassie "Bam!" or two on fruit cocktail or fresh fruit.
One of the Bio-Tech D3-50 50,000 IU water soluble vitamin D3 capsules a week gives you 7100 IU/day vitamin D3 so you're in great shape on that count. It's still a good idea to pick up some 30 mg or 50 mg zinc tablets. Zinc picolinate has the highest bioavailability. However, its availability on amazon is starting to run low so I wouldn't delay in placing some on order. If it's out of stock, zinc gluconate is also acceptable.
Understanding the rationale for zinc is important. It interrupts the SARS-CoV-2 virus spike that gains access to cells lining the lung's alveoli at the Angiotensin Converting Enzyme 2 (ACE-2) receptor on the cell walls. (You can google "ACE-2" for some great graphic details on the SARS-CoV-2 virus infection process). If the virus does gain access to the cell nuclei, zinc enters infected cells to stop the virus RNA from replicating.
I would also add Resveratrol or better yet the Resveratrol analog, Pterostilbene as it has a significantly higher (4 X) bioavailability. Like zinc, Pterostilbene inhibits the replication of SARS-coronavirus (SARS-CoV) by inhibiting the RNA-synthesizing activity of SARS-CoV polymerases. I ordered some from amazon yesterday.
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Our immune system is the only weapon we have in preventing and treating viral infections effectively. It's been protecting us from viral infections for thousands of years before the advent of modern medicine and vaccines or we wouldn't be here.
Keeping our immune systems healthy with proper nutrients is key. Antiviral interventions like acyclovir are largely ineffective as they only slow the rate of infection. Vaccines are also relatively ineffective in preventing viral infections. They also insult the immune system making us more likely to be vulnerable to other pathogens.
Most of us have watched enough of the daily COVID-19 pressers to hear about hydroxychloroquine. I have a degree in Chemistry and spent the better part of two years studying organic chemistry so I'll decipher this drug for you. For starters, hydroxychloroquine is basically a man made analog of naturally occurring quinine (used to treat malaria) with a hydroxyl [OH] group added on one end of the quinine molecule, a chlorine atom on the other end and a rearrangement of a Quinine ring.
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A very sharp molecular virologist analyzed the hydroxychloroquine mechanism of action in treating COVID-19 infections and found this drug releases available zinc from a binding protein. Accordingly, taking zinc is likely a reasonable alternative if hydroxychloroquine is not available. (I'll take it anyway along with 50,000 IU/week vitamin D3, vitamin C, zinc and Pterostilbene). There are likely going to be shortages of this drug until production ramps up.
The mechanism of action for vitamin C in the prevention and treatment of COVID-19 infection is relatively straight forward. Vitamin C is a potent antiviral so it destroys the SARS-CoV-2 virus on contact. Vitamin C not used by cells in the body gets filtered by the kidneys and pumped over the side in urine. It has a biological half-life of roughly 30 minutes, so we need to dose frequently during the day to maintain its serum concentration as high as possible.
The rationale for taking vitamin D3 is also straight forward. It mediates (controls) immune cell activity through genetic expression. Genetic expression is the same basic mechanism of action that helps vitamin D3 prevent CH and MH. Researches have found there's a huge rush of immune system killer cells and T-killer cells to the lungs during a COVID-19 infection. The killer cells literally eat and digest the SARS-CoV-2 virus and the T-killer cells eat the infected lung cells.
This process creates a lot of cellular waste build up in the alveoli making breathing even more difficult. When this happens the inevitable pneumonia caused by a COVID-19 infection that has already made breathing difficult, progresses to Acute Respiratory Distress Syndrome (ARDS). At that point patients expend so much energy trying to breath, they tire out and slow breathing and this causes blood oxygen content to drop. This is the point when patients are placed on a ventilator, essentially to breathe for them.
Available clinical data from two gold standard RCTs indicate these two rescue protocols are safe, effective and the needed formulations are readily available. The first is IV Vitamin C (IVC) and the second is the IV combination of Hydrocortisone, Ascorbic Acid and Thiamine (HAT) Metabolic Resuscitation protocol. Both of these protocols have the greatest efficacy if started as soon as the COVID-19 patient is hospitalized. They have also shown efficacy over placebo after the patient has been intubated and placed on a respirator as illustrated in the following graphic from the IVC RCT. You need to ask the CDC why they refuse to recommend this treatment protocol.
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There are more than a few experts in nutritional medicine who opine survivability of these two rescue protocols could be further improved with oral vitamin D3 and zinc upon hospitalization along with continued oral vitamin C following the IVC.
God forbid any of us come down with COVID-19, so I'll tell you what I intend to do should this happen. As soon as there's any indication of an infection, I'll call my PCP and immediately start loading vitamin D3 at 50,000 IU/day, double the vitamin C and Pterostilbene. As soon as it appears the infection is causing difficulty breathing, I'm headed for the ER.
Upon hospital admission I will voice my preference for either of the IVC or HAT rescue protocols. It's important to have this preference entered on the admission documentation as no members of the family will be allowed in the ER or ICU. Moreover, should the COVID-19 infection progresses to the point where a respirator is required, they'll shove a tube down your trachea and you will not be able to talk.
So much for a worse case event. I'm confident, the above preventative protocol should reduce the probability of infection and should it occur, it should be relatively mild.
I ventured out Monday to pick up some fresh veggies and staples and was pleased to see Costco had 15 full pallets stacked with Charmin TP, but no paper towels or tissues. Our local Safeway shelves for paper products were still completely bare with the exception of a few boxes of tissues that were marked one to a customer. Safeway was out of vitamin C and zinc, but there was still vitamin D3 on the shelves.
In summary, we are at war with the SARS-CoV-2 virus and the COVID-19 infection it causes. SARS-CoV-2 is a novel (first time seen) virus that does not behave like wild-type coronavirus. Data from case studies indicate this virus was likely engineered as a chimeric, weaponized virus possibly at the BSL-4 facility in Wuhan, China with gain of function. The gain of function appears to include a higher rate of infection than wild-type coronavirus and the capacity to encapsulate to avoid detection with RT-PCR tests and reemerge 5 to 8 days after recovery (as indicated by normal chest X-Ray and negative RT-PCR test), shedding virus once again. This may answer the apparent second wave function seen in other countries. Senator Cotton thinks the same way.
We are at war with a strand of RNA guided by a genetic code to invade host lung cells, replicate, kill the cell and spread to other cells then move on to other hosts again and again.
There are no Rx medication approved by the FDA for use in treating this specific virus as it wasn't sequenced until 10 Jan 2020 and wasn't ID'd with a name by the WHO until 12 Jan 2020. The HHS, CDC and FDA are regulatory organizations. Nowhere in their respective mission statements does it say suggest alternate treatment modalities for diseases like COVID-19 if no FDA approved treatments are available. The CDC did know from a 2010 research paper, the combination of zinc plus a zinc transport molecule (ionophore) that facilitates zinc’s entry into cells efficiently impairing the replication of RNA viruses, like the SARS-CoV coronavirus. However the CDC fails to acknowledge papers like this because they don't meet the strict rules of medical evidence developed by the medical evidence mafia, Big Pharma's enforcement arm.
Accordingly, the CDC and FDA appear to be content to let Americans die from COVID-19 while issuing passive mitigation guidance for hand hygiene, social separation, lock-down and confusing mask requirements while they wait for the much heralded COVID-19 vaccine 17 months from now. You need to ask Why?
On the vaccine topic, the CDC's own data on vaccine efficacy for influenza indicates an NNV of 71 for the average flu vaccine. (NNV = Number needed to vaccinate to prevent one case of the flu). This means that 70 of the 71 vaccinated with the flu vaccine have no protection for infection by flu virus. See: Multimedia File Viewing and Clickable Links are available for Registered Members only!! You need to

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This begs the pregnant question, what is an acceptable NNV for the SARS-CoV-2 vaccine we'll see in 17 months after the needless loss of lives from COVID-19?
With the exception of my intended actions should the fit hits the shan, everything in this post has published references. I'm just the messenger.
My motivation in starting this thread is simple. I joined CH.com on a mission to provide information on safe and effective nutritional measures we can take to prevent cluster and migraine headache. That information has always been coupled with the caveat to see your PCP/GP should you decide to put this information into action. In late January of this year, that mission changed. Now my information outreach is focused on nutritional measures we can take to save lives.
Accordingly, If any of you find this PSA thread and my posts so inappropriate for this venue you're moved to protest, live with it or don't read this thread. If you do decide to post in protest, please tell us why trying to save lives, particularly, the lives of fellow CHers and dear friends, is not on your list of "Things To Do". I would just as soon have you here pitching hissies a month from now when this pandemic drops to a dull roar than not.
Take care,
V/R, Batch